Understanding and application of daptomycin-susceptible dose-dependent category for Enterococcus: A mixed-methods study

Background: In 2018, the Clinical Microbiology Laboratory at our institution adopted updated daptomycin Methods: This mixed-methods study combined a clinician survey with a retrospective pre-post prescribing analysis. An 8-question survey was distributed to infectious diseases (ID) and internal medicine (IM) clinicians. A retrospective chart review of hospitalized adults with infections due to Results: Survey response rates were 40 of 98 (41%) for IM and 22 of 34 (65%) for ID clinicians. ID clinicians scored significantly higher than IM clinicians in knowledge of SDD. Chart review of 474 patients (225 pre- vs 249 post-SDD) showed that daptomycin dosage following susceptibility testing was significantly higher post-SDD compared with pre-SDD (8.5 mg/kg vs 6.4 mg/kg; Conclusions: The survey revealed that ID clinicians placed more importance on and had more confidence in the SDD category over IM clinicians. SDD reporting was associated with a change in definitive daptomycin dosing. ID specialist involvement is recommended in the care of infections due to enterococci for which daptomycin is reported as SDD given their expertise

STUDYING WOMEN'S SUBSTANTIVE REPRESENTATION IN LEGISLATURES: WHEN REPRESENTATIVE ACTS, CONTEXTS AND WOMEN'S INTERESTS BECOME IMPORTANT

The lack of consensus regarding what the substantive representation of women means involves far reaching consequences for empirical research. This article illustrates some consequences of specific operationalisations of 'the substantive representation of women'. It shows that, in order to understand the substantive representation of women, as it is performed by multiple representatives, empirical research needs to encompass a broad range of representative acts and contexts. It also benefits from including a wide conception of women's interests and women's perspectives