The application of pulse excitation to ground and flight vibration tests

A discussion of the relative merits of sinusoidal versus nonharmonic excitation for flight flutter testing is presented. It is concluded that the use of transient excitation is rapidly becoming a necessity. The application of small-scale rocket motors to the excitation of the aircraft is suggested. The design and development of rocket motors specifically for flight flutter testing is described. Methods of measuring and analyzing the transient response of the aircraft are discussed, and the techniques of theoretically predicting the structural response are described

On a Modification of the Boundary State Formalism in Off-shell String Theory

We examine the application of boundary states in computing amplitudes in off-shell open string theory. We find a straightforward generalization of boundary state which produces the correct matrix elements with on-shell closed string states.Comment: Latex, 10 pages, refs added, minor typos correcte

Effect of tamoxifen on Ki67 labelling index in human breast tumours and its relationship to oestrogen and progesterone receptor status.

This study aimed to investigate the effect of tamoxifen on breast tumour levels of oestrogen and progesterone receptor (ER and PR) and proliferation as defined by the Ki67 antibody. A group of primary breast cancer patients was randomised to receive either tamoxifen (n = 59) or placebo (n = 44) treatment in the interval between clinic and surgery (median 21 days). Frozen sections of breast tumour biopsies obtained before and after treatment were stained immunocytochemically to obtain the percentage of nuclei containing ER and PR, and a Ki67 labelling index (LI). Tamoxifen-treated patients had a median Ki67 LI of 5.6% in the first biopsy falling to 3.0% in the second biopsy (P < 0.001 by Wilcoxon's matched pairs test), whereas placebo-treated patients had a median Ki67 LI of 5.4% in the first biopsy and 5.75% in the second (no significant difference). No significant differences were observed when the median %ER or %PR staining before and after treatment were compared. The Ki67 LI tended to increase with increasing histological grade and was greater in tumours that were ER - ve compared to those that were ER + ve (> 5% nuclei stained), median 7.8% and 4.3% respectively (P = 0.011 by Mann-Whitney U-test). However, the decline in tumour Ki67 LI following anti-oestrogen treatment failed to correlate with ER and PR status or to predict recurrence over a short follow-up period. To our knowledge, this is the first time that tamoxifen treatment has been shown to reduce the Ki67 LI in human breast tumours in vivo. These data indicate that staining with the Ki67 antibody may be useful in monitoring response to anti-oestrogen therapy

Behaviour of three charged particles on a plane under perpendicular magnetic field

We consider the problem of three identical charged particles on a plane under a perpendicular magnetic field and interacting through Coulomb repulsion. This problem is treated within Taut's framework, in the limit of vanishing center of mass vector $\vec{R} \to \vec{0}$, which corresponds to the strong magnetic field limit, occuring for example in the Fractional Quantum Hall Effect. Using the solutions of the biconfluent Heun equation, we compute the eigenstates and show that there is two sets of solutions. The first one corresponds to a system of three independent anyons which have their angular momenta fixed by the value of the magnetic field and specified by a dimensionless parameter $C \simeq \frac{l_B}{l_0}$, the ratio of $l_B$, the magnetic length, over $l_0$, the Bohr radius. This anyonic character, consistent with quantum mechanics of identical particles in two dimensions, is induced by competing physical forces. The second one corresponds to the case of the Landau problem when $C \to 0$. Finally we compare these states with the quantum Hall states and find that the Laughlin wave functions are special cases of our solutions under certains conditions.Comment: 15 pages, 3 figures, Accepeted in JP

Inverting the handedness of circularly polarized luminescence from light-emitting polymers using film thickness

The emission of circularly polarized light is central to many applications, including data storage, optical quantum computation, biosensing, environmental monitoring, and display technologies. An emerging method to induce (chiral) circularly polarized (CP) electroluminescence from the active layer of polymer light-emitting diodes (polymer OLEDs; PLEDs) involves blending achiral polymers with chiral small-molecule additives, where the handedness/sign of the CP light is controlled by the absolute stereochemistry of the small molecule. Through the in-depth study of such a system we report an interesting chiroptical property: the ability to tune the sign of CP light as a function of active layer thickness for a fixed enantiomer of the chiral additive. We demonstrate that it is possible to achieve both efficient (4.0 cd/A) and bright (8000 cd/m2) CP-PLEDs, with high dissymmetry of emission of both left-handed (LH) and right-handed (RH) light, depending on thickness (thin films, 110 nm: gEL = 0.51, thick films, 160 nm: gEL = -1.05, with the terms "thick" and "thin" representing the upper and lower limits of the thickness regime studied), for the same additive enantiomer. We propose that this arises due to an interplay between localized CP emission originating from molecular chirality and CP light amplification or inversion through a chiral medium. We link morphological, spectroscopic, and electronic characterization in thin films and devices with theoretical studies in an effort to determine the factors that underpin these observations. Through the control of active layer thickness and device architecture, this study provides insights into the mechanisms that result in CP luminescence and high performance from CP-PLEDs, as well as demonstrating new opportunities in CP photonic device design

Point defects and interstitial climb of 90° partial dislocations in brown type IIa natural diamond

Multiple electron microscopy techniques have been used to study a brown type IIa natural diamond. Electron backscatter diffraction shows evidence of plastic deformation in the form of slip bands, while cathodoluminescence reveals a network of low-angle grain boundaries, also observed in transmission electron microscopy together with long straight dislocations and dislocation dipoles. Aberration-corrected scanning transmission electron microscopy shows interstitial absorption on the 90° partial of both dissociated dislocations and Z-type faulted vacancy dipoles, forming structures similar to that observed in other fcc materials. The observations indicate an interstitial concentration of 1017 to 1019 cm-3 and calculations of point defect concentrations produced by plastic deformation show that this can be produced by strains of the order of 1%. Brown coloration in diamond has been previously attributed to vacancies and vacancy clusters with concentrations around 1018 cm-3, which suggests that roughly equal numbers of interstitials and vacancies are generated in diamond via plastic deformation. Atomic resolution images of Z-type faulted dipoles allow a stacking fault energy of 472 ± 38 mJ m-2 to be determined

Unitary Equivalence of the Metric and Holonomy Formulations of 2+1 Dimensional Quantum Gravity on the Torus

Recent work on canonical transformations in quantum mechanics is applied to transform between the Moncrief metric formulation and the Witten-Carlip holonomy formulation of 2+1-dimensional quantum gravity on the torus. A non-polynomial factor ordering of the classical canonical transformation between the metric and holonomy variables is constructed which preserves their classical modular transformation properties. An extension of the definition of a unitary transformation is briefly discussed and is used to find the inner product in the holonomy variables which makes the canonical transformation unitary. This defines the Hilbert space in the Witten-Carlip formulation which is unitarily equivalent to the natural Hilbert space in the Moncrief formulation. In addition, gravitational theta-states arising from ``large'' diffeomorphisms are found in the theory.Comment: 31 pages LaTeX [Important Revision: a section is added constructing the inner product/Hilbert space for the Witten-Carlip holonomy formulation; the proof of unitary equivalence of the metric and holonomy formulations is then completed. Other additions include discussion of relation of canonical and unitary transformations. Title/abstract change.

Elective Modernism and the Politics of (Bio) Ethical Expertise

In this essay I consider whether the political perspective of third wave science studies – ‘elective modernism’ – offers a suitable framework for understanding the policy-making contributions that (bio)ethical experts might make. The question arises as a consequence of the fact that I have taken inspiration from the third wave in order to develop an account of (bio)ethical expertise. I offer a précis of this work and a brief summary of elective modernism before considering their relation. The view I set out suggests that elective modernism is a political philosophy and that although its use in relation to the use of scientific expertise in political and policy-making process has implications for the role of (bio)ethical expertise it does not, in the final analysis, provide an account that is appropriate for this latter form of specialist expertise. Nevertheless, it is an informative perspective, and one that can help us make sense of the political uses of (bio)ethical expertise

Remarks on the Configuration Space Approach to Spin-Statistics

The angular momentum operators for a system of two spin-zero indistinguishable particles are constructed, using Isham's Canonical Group Quantization method. This mathematically rigorous method provides a hint at the correct definition of (total) angular momentum operators, for arbitrary spin, in a system of indistinguishable particles. The connection with other configuration space approaches to spin-statistics is discussed, as well as the relevance of the obtained results in view of a possible alternative proof of the spin-statistics theorem.Comment: 18 page