Characteristics of patients in the meta-analysis.

<p>BMI: body mass index; HIV: human immunodeficiency virus; DM: diabetes mellitus; ALT: alanine aminotransferase; IFN: interferon; RBV: ribavirin.</p

ORs and 95% CI of the association between SVR and hyperglycemia.

<p>SVR was associated with a lower risk of hyperglycemia in chronic HCV patients (OR = 0.497; 95% CI 0.421–0.587). There was no evidence of substantial between-study heterogeneity.</p

Characteristics of meta-analysis eligible studies examining the association between SVR and Hyperglycemia.

<p>Hyper/SVR: the risk of hyperglycemia in CHC patients who acquired sustained virological responses; NOR/SVR: data of normal glucose in CHC patients who acquired sustained virological responses; Hyper/NONSVR: the risk of hyperglycemia in CHC patients who did not acquire sustained virological responses; NOR/NONSVR: data of normal glucose in CHC patients who did not acquire sustained virological responses; OR: odds ratio; HR: hazard ratio; NR: not reported.</p

Viral infectivity detection of supernatant DENV in Huh7-BST2 and Huh7-BST2CV5 cells.

<p>The viral infectivity of supernatant DENV was determined by TCID50 method. The cells were infected with DENV at indicated MOI for 1 h; the media were replaced with complete media and cultured for 2 days. Dengue E protein was assayed by A cell-based flavivirus immunodetection assay. The values represent average from 3 independent experiments (n = 3). <i>p</i> values were calculated using Student's t test.</p

In-cell western analysis for DENV infection in Huh7-BST2 and Huh7-BST2CV5 cells.

<p>Cells were infected with DENV at indicated MOI and cultured for 2 days with complete medium. Cells were fixed and double-staining of DENV 4G2 protein and BST2 were revealed by In-Cell western assay. The indicated gray values of the dots were quantified by using of an Odyssey Infrared Imaging System (LI-COR Biotechnology). The values represent average from 3 independent experiments.</p

Funnel plot.

<p>The funnel plot’s shape is in asymmetrical. There was no significant publication bias indicated in the main analysis.</p

Immunofluorescent staining for DENV infection in Huh7-BST2 and Huh7-BST2CV5 cells.

<p>Cells were infected with DENV at indicated MOI and harvested on day 2. Cells were double-stained for DENV envelope protein 4G2 (top panel, green) and BST2 (middle panel, red). Cell nuclei were stained with DAPI (bottom panel, blue).</p

Tricyclic Sesquiterpenes from Marine Origin

The structure elucidation, biosynthesis, and biological activity of marine carbotricyclic sesquiterpene compounds are reviewed from the pioneering results to the end of 2015. Their total syntheses with a particular emphasis on the first syntheses, enantiomeric versions, and syntheses that led to the revision of structures or stereochemistries are summarized. Overall, 284 tricyclic compounds are classified into fused, bridged, and miscellaneous structures based on 54 different skeletal types. Tricyclic sesquiterpenes constitute an important group of natural products. Their structural diversity and biological activities have generated further interest in the field of drug discovery research, although the exact mechanisms of action of these species are not well known. Furthermore, these tricyclic structures, according to their chemical complexity, are a source of inspiration for chemists in the field of total synthesis for the development of innovative methodologies

Ancestral state reconstruction for the androecium in the major clade Rutaceae.

<p>The topology of the sampled species was determined according to Groppo et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137190#pone.0137190.ref004" target="_blank">4</a>], Salvo et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137190#pone.0137190.ref013" target="_blank">13</a>], Poon et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137190#pone.0137190.ref011" target="_blank">11</a>], Morton et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137190#pone.0137190.ref017" target="_blank">17</a>], and Manafzadeh et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137190#pone.0137190.ref043" target="_blank">43</a>]. The different colors represent the different status of androecium.</p

Floral development in <i>Haplophyllum dauricum</i>.

<p>A: Apical view of a young inflorescence with lateral subunits. B, C: Apical view of a young floral bud showing the initiation sequence of the sepals. D: Initiation of petals. E: Initiation of antesepalous stamens. Arrows indicate the primordia. F: Initiation of antepetalous stamens. Arrows indicate the primordia. G: Fully initiated androecium showing the different sizes of antesepalous and antepetalous stamens. H: Apical view of a floral bud in the middle stage. I: Initiation of carpels. J: Development of the three carpels (note: in rare cases, as shown here, an additional stamen may be formed). K: Later stage of carpel development. L: Post-genital union of three carpels. M: Later stage of the floral bud, showing the peripheral position of the antepetalous stamens. N: Apical view of a floral bud with a tetramerous mutation showing the antepetalous position of the carpels. O: Transection of the mature ovary. Abbreviations: S, sepal; P, petal; As, antesepalous stamen; Ap, antepetalous stamen; C, carpel. Scale bars = 40 μm.</p