792 research outputs found
Collider Inclusive Jet Data and the Gluon Distribution
Inclusive jet production data are important for constraining the gluon
distribution in the global QCD analysis of parton distribution functions. With
the addition of recent CDF and D0 Run II jet data, we study a number of issues
that play a role in determining the up-to-date gluon distribution and its
uncertainty, and produce a new set of parton distributions that make use of
that data. We present in detail the general procedures used to study the
compatibility between new data sets and the previous body of data used in a
global fit. We introduce a new method in which the Hessian matrix for
uncertainties is ``rediagonalized'' to obtain eigenvector sets that
conveniently characterize the uncertainty of a particular observable.Comment: Published versio
Three-Tier Capacity and Traffic Allocation for Core, Edges, and Devices for Mobile Edge Computing
In order to satisfy the 5G requirements of ultra-low latency, mobile edge computing (MEC)-based architecture, composed of three-tier nodes, core, edges, and devices, is proposed. In MEC-based architecture, previous studies focused on the controlplane issue, i.e., how to allocate traffic to be processed at different nodes to meet this ultra-low latency requirement. Also important is how to allocate the capacity to different nodes in the management plane so as to establish a minimal-capacity network. The objectives of this paper is to solve two problems: 1) to allocate the capacity of all nodes in MEC-based architecture so as to provide a minimal-capacity network and 2) to allocate the traffic to satisfy the latency percentage constraint, i.e., at least a percentage of traffic satisfying the latency constraint. In order to achieve these objectives, a two-phase iterative optimization (TPIO) method is proposed to try to optimize capacity and traffic allocation in MEC-based architecture. TPIO iteratively uses two phases to adjust capacity and traffic allocation respectively because they are tightly coupled. In the first phase, using queuing theory calculates the optimal traffic allocation under fixed allocated capacity, while in the second phase, allocated capacity is further reduced under fixed traffic allocation to satisfy the latency percentage constraint. Simulation results show that MEC-based architecture can save about 20.7% of capacity of two-tier architecture. Further, an extra 12.2% capacity must be forfeited when the percentage of satisfying latency is 90%, compared to 50%.This work was supported in part by H2020 collaborative Europe/Taiwan research project 5G-CORAL (grant number 761586), and
Ministry of Science and Technology, Taiwan for financially supporting this
research under Contract No. MOST 106-2218-E-009-018
Heavy Quark Mass Effects in Deep Inelastic Scattering and Global QCD Analysis
A new implementation of the general PQCD formalism of Collins, including
heavy quark mass effects, is described. Important features that contribute to
the accuracy and efficiency of the calculation of both neutral current (NC) and
charged current (CC) processess are explicitly discussed. This new
implementation is applied to the global analysis of the full HERA I data sets
on NC and CC cross sections, with correlated systematic errors, in conjunction
with the usual fixed-target and hadron collider data sets. By using a variety
of parametrizations to explore the parton parameter space, robust new parton
distribution function (PDF) sets (CTEQ6.5) are obtained. The new quark
distributions are consistently higher in the region x ~ 10^{-3} than previous
ones, with important implications on hadron collider phenomenology, especially
at the LHC. The uncertainties of the parton distributions are reassessed and
are compared to the previous ones. A new set of CTEQ6.5 eigenvector PDFs that
encapsulates these uncertainties is also presented.Comment: 32 pages, 12 figures; updated, Publication Versio
The Strange Parton Distribution of the Nucleon: Global Analysis and Applications
The strangeness degrees of freedom in the parton structure of the nucleon are
explored in the global analysis framework, using the new CTEQ6.5 implementation
of the general mass perturbative QCD formalism of Collins. We systematically
determine the constraining power of available hard scattering experimental data
on the magnitude and shape of the strange quark and anti-quark parton
distributions. We find that current data favor a distinct shape of the strange
sea compared to the isoscalar non-strange sea. A new reference parton
distribution set, CTEQ6.5S0, and representative sets spanning the allowed
ranges of magnitude and shape of the strange distributions, are presented. Some
applications to physical processes of current interest in hadron collider
phenomenology are discussed.Comment: 19 pages; revised version submitted to JHE
The Anti-hepatitis B Virus Activity of Boehmeria nivea Extract in HBV-viremia SCID Mice
Boehmeria nivea extract (BNE) is widely used in southern Taiwan as a folk medicine for hepato-protection and hepatitis treatment. In previous studies, we demonstrated that BNE could reduce the supernatant hepatitis B virus (HBV) DNA in HBV-producing HepG2 2.2.15 cells. In the present study, we established an animal model of HBV viremia and used it to validate the efficacy of BNE in vivo. In this animal model, serum HBV DNA and HBsAg were elevated in accordance with tumor growth. To evaluate the anti-HBV activity of BNE, HBV-viremia mice were built up after one subcutaneous inoculation of HepG2 2.2.15 tumor cells in severe combined immunodeficiency mice over 13 days. The levels of serum HBV DNA were elevated around 105–106 copies per milliliter. Both oral and intraperitoneal administration of BNE were effective at inhibiting the production of HBsAg and HBV DNA, whereas tumor growth was not affected by all test articles. Intraperitoneal administration of BNE appeared to have greater potential to inhibit serum HBV DNA levels compared with oral administration under the same dosage. Notably, reduced natural killer cell activity was also observed after high dosage of BNE administration, and this correlated with reduced serum HBV DNA. In conclusion, BNE exhibited potential anti-HBV activity in an animal model of HBV viremia
Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells
Tien-Hsien Liquid (THL) is a Chinese herbal mixture that has been used worldwide as complementary treatment for cancer patients in the past decade. Recently, THL has been shown to induce apoptosis in various types of solid tumor cells in vitro. However, the underlying molecular mechanisms have not yet been well elucidated. In this study, we explored the effects of THL on acute promyelocytic leukemia (APL) NB4 cells, which could be effectively treated by some traditional Chinese remedies containing arsenic trioxide. The results showed THL could induce G2/M arrest and apoptosis in NB4 cells. Accordingly, the decrease of cyclin A and B1 were observed in THL-treated cells. The THL-induced apoptosis was accompanied with caspase-3 activation and decrease of PML-RARα fusion protein. Moreover, DNA methyltransferase 1 and oncogenic signaling pathways such as Akt/mTOR, Stat3 and ERK were also down-regulated by THL. By using ethyl acetate extraction and silica gel chromatography, an active fraction of THL named as EAS5 was isolated. At about 0.5–1% of the dose of THL, EAS5 appeared to have most of THL-induced multiple molecular targeting effects in NB4 cells. Based on the findings of these multi-targeting effects, THL might be regarding as a complementary and alternative therapeutic agent for refractory APL
Implications of CTEQ global analysis for collider observables
The latest CTEQ6.6 parton distributions, obtained by global analysis of hard
scattering data in the framework of general-mass perturbative QCD, are employed
to study theoretical predictions and their uncertainties for significant
processes at the Fermilab Tevatron and CERN Large Hadron Collider. The
previously observed increase in predicted cross sections for the
standard-candle W and Z boson production processes in the general-mass scheme
(compared to those in the zero-mass scheme) is further investigated and
quantified. A novel method to constrain PDF uncertainties in LHC observables,
by effectively exploiting PDF-induced correlations with benchmark standard
model cross sections, is presented. Using this method, we show that the
top-antitop pair cross section can potentially serve as a standard candle
observable for the LHC processes dominated by initial-state gluon scattering.
Among other benefits, precise measurements of cross sections would
reduce PDF uncertainties in predictions for single-top quark and Higgs boson
production in the standard model and minimal supersymmetric standard model.Comment: 32 pages, 15 figures; figures with embedded fonts available at
http://hep.pa.msu.edu/cteq/public/6.6/pdfs/; extended discussion of small-x
strangeness, added references, minor changes in Figs. 2-4 in the revised
versio
Parton Distributions for Event Generators
In this paper, conventional Global QCD analysis is generalized to produce
parton distributions optimized for use with event generators at the LHC. This
optimization is accomplished by combining the constraints due to existing
hard-scattering experimental data with those from anticipated cross sections
for key representative SM processes at LHC (by the best available theory) as
joint input to the global analyses. The PDFs obtained in these new type of
global analyses using matrix elements calculated in any given order will be
best suited to work with event generators of that order, for predictions at the
LHC. This is most useful for LO event generators at present. Results obtained
from a few candidate PDF sets (labeled as CT09MCS, CT09MC1 and CT09MC2) for LO
event generators produced in this way are compared with those from other
approaches.Comment: 35 pages, 19 figures, and 4 table
Corrigendum to “Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/ β
Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/ β
Honokiol, an active compound of Magnolia officinalis, exerted many anticancer effects on various types of cancer cells. We explored its effects on the elimination of cancer stem-like side population (SP) cells in human oral squamous cell carcinoma SAS cells. The sorted SP cells possessed much higher expression of stemness genes, such as ABCG2, ABCC5, EpCAM, OCT-4, CD133, CD44, and β-catenin, and more clonogenicity as compared with the Non-SP cells. After 48 h of treatment, honokiol dose dependently reduced the proportion of SP from 2.53% to 0.09%. Apoptosis of honokiol-treated SP cells was evidenced by increased annexin V staining and cleaved caspase-3 as well as decreased Survivin and Bcl-2. Mechanistically, honokiol inhibited the CD44 and Wnt/β-catenin signaling of SP cells. The Wnt signaling transducers such as β-catenin and TCF-4 were decreased in honokiol-treated SP cells, while the β-catenin degradation promoting kinase GSK-3α/β was increased. Consistently, the protein levels of β-catenin downstream targets such as c-Myc and Cyclin D1 were also downregulated. Furthermore, the β-catenin-related EMT markers such as Slug and Snail were markedly suppressed by honokiol. Our findings indicate honokiol may be able to eliminate oral cancer stem cells through apoptosis induction, suppression of Wnt/β-catenin signaling, and inhibition of EMT
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