Distributed Indexing Schemes for k-Dominant Skyline Analytics on Uncertain Edge-IoT Data

Skyline queries typically search a Pareto-optimal set from a given data set to solve the corresponding multiobjective optimization problem. As the number of criteria increases, the skyline presumes excessive data items, which yield a meaningless result. To address this curse of dimensionality, we proposed a k-dominant skyline in which the number of skyline members was reduced by relaxing the restriction on the number of dimensions, considering the uncertainty of data. Specifically, each data item was associated with a probability of appearance, which represented the probability of becoming a member of the k-dominant skyline. As data items appear continuously in data streams, the corresponding k-dominant skyline may vary with time. Therefore, an effective and rapid mechanism of updating the k-dominant skyline becomes crucial. Herein, we proposed two time-efficient schemes, Middle Indexing (MI) and All Indexing (AI), for k-dominant skyline in distributed edge-computing environments, where irrelevant data items can be effectively excluded from the compute to reduce the processing duration. Furthermore, the proposed schemes were validated with extensive experimental simulations. The experimental results demonstrated that the proposed MI and AI schemes reduced the computation time by approximately 13% and 56%, respectively, compared with the existing method.Comment: 13 pages, 8 figures, 12 tables, to appear in IEEE Transactions on Emerging Topics in Computin

Data-Driven 3D Placement of UAV Base Stations for Arbitrarily Distributed Crowds

In this paper, we consider an Unmanned Aerial Vehicle (UAV)-assisted cellular system which consists of multiple UAV base stations (BSs) cooperating the terrestrial BSs. In such a heterogeneous network, for cellular operators, the problem is how to determine the appropriate number, locations, and altitudes of UAV-BSs to improve the system sumrate as well as satisfy the demands of arbitrarily flash crowds on data rates. We propose a data-driven 3D placement of UAV-BSs for providing an effective placement result with a feasible computational cost. The proposed algorithm searches for the appropriate number, location, coverage, and altitude of each UAV-BS in the serving area with the maximized system sumrate in polynomial time so as to guarantee the minimum data rate requirement of UE. The simulation results show that the proposed approach can improve system sumrate in comparison with the case without UAV-BSs.Comment: 6 pages, 3 figures, accepted by 2019 IEEE Global Communications Conference: Wireless Communications (Globecom2019 WC

Interference-Aware Deployment for Maximizing User Satisfaction in Multi-UAV Wireless Networks

In this letter, we study the deployment of Unmanned Aerial Vehicle mounted Base Stations (UAV-BSs) in multi-UAV cellular networks. We model the multi-UAV deployment problem as a user satisfaction maximization problem, that is, maximizing the proportion of served ground users (GUs) that meet a given minimum data rate requirement. We propose an interference-aware deployment (IAD) algorithm for serving arbitrarily distributed outdoor GUs. The proposed algorithm can alleviate the problem of overlapping coverage between adjacent UAV-BSs to minimize inter-cell interference. Therefore, reducing co-channel interference between UAV-BSs will improve user satisfaction and ensure that most GUs can achieve the minimum data rate requirement. Simulation results show that our proposed IAD outperforms comparative methods by more than 10% in user satisfaction in high-density environments.Comment: 5 pages, 3 figures, to appear in IEEE Wireless Communications Letter

α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding.

Invariant natural killer T (iNKT) cells, which are activated by T cell receptor (TCR)-dependent recognition of lipid-based antigens presented by the CD1d molecule, have been shown to participate in the pathogenesis of many diseases, including asthma and liver injury. Previous studies have shown the inhibition of iNKT cell activation using lipid antagonists can attenuate iNKT cell-induced disease pathogenesis. Hence, the development of iNKT cell-targeted glycolipids can facilitate the discovery of new therapeutics. In this study, we synthesized and evaluated α-lactosylceramide (α-LacCer), an α-galactosylceramide (α-GalCer) analog with lactose substitution for the galactose head and a shortened acyl chain in the ceramide tail, toward iNKT cell activation. We demonstrated that α-LacCer was a weak inducer for both mouse and human iNKT cell activation and cytokine production, and the iNKT induction by α-LacCer was CD1d-dependent. However, when co-administered with α-GalCer, α-LacCer inhibited α-GalCer-induced IL-4 and IFN-γ production from iNKT cells. Consequently, α-LacCer also ameliorated both α-GalCer and GSL-1-induced airway hyperreactivity and α-GalCer-induced neutrophilia when co-administered in vivo. Furthermore, we were able to inhibit the increases of ConA-induced AST, ALT and IFN-γ serum levels through α-LacCer pre-treatment, suggesting α-LacCer could protect against ConA-induced liver injury. Mechanistically, we discerned that α-LacCer suppressed α-GalCer-stimulated cytokine production through competing for CD1d binding. Since iNKT cells play a critical role in the development of AHR and liver injury, the inhibition of iNKT cell activation by α-LacCer present a possible new approach in treating iNKT cell-mediated diseases