6 research outputs found
Correction to: Dimensions of leisure-time physical activity and risk of depression in the “Seguimiento Universidad de Navarra” (SUN) prospective cohort
After publication of our article [1] we have been notified that Table 2 was incorrectly formatte
Lifestyles and the risk of depression in the “Seguimiento Universidad de Navarra” cohort
Background: Lifestyles are involved in the pathogenesis of depression and many of these factors can be
modified for the potential prevention of depression. Our aim was to assess the association between a
healthy-lifestyle score, that includes some less-studied lifestyle indicators, and the risk of depression.
Methods: We followed 14,908 participants initially free of any history of depression in the “Seguimiento
Universidad de Navarra” (SUN) cohort. Information was collected biennially from 1999 to December
2016. We calculated a healthy-lifestyle score (0–10 points), previously associated with cardioprotection,
by giving one point to each of the following components: never smoking, physical activity (> 20 METs-h/
week), Mediterranean diet adherence ( 4 points), healthy body mass index ( 22 kg/m2
), moderate
alcohol consumption (women 0.1–5 g/d; men 0.1–10 g/d of ethanol), avoidance of binge drinking (never
more than 5 alcoholic drinks in a row), low television exposure ( 2 h/d), short afternoon nap ( 30 min/
day), time spent with friends (>1 h/d) and working at least 40 h/week.
Results: During a median follow-up of 10.4 years, we observed 774 new cases of major depression among
participants initially free of depression. The highest category (8–10 factors) showed a significant inverse
association with a 32% relative risk reduction for depression compared to the lowest category (0–3
factors) (multivariable-adjusted hazard ratio: 0.68; 95% CI:0.49-0.95) (p for trend = 0.010).
Conclusions: Adopting a healthy-lifestyle was associated with a lower risk of incident depression in the
SUN cohort. This index, including ten simple healthy lifestyle habits, may be useful for a more integrative
approach to depression prevention
Correction to: Dimensions of leisure-time physical activity and risk of depression in the “Seguimiento Universidad de Navarra” (SUN) prospective cohort
After publication of our article [1] we have been notified that Table 2 was incorrectly formatte
Ultra‐processed food consumption and the incidence of depression in a Mediterranean cohort: the SUN Project
Purpose A growing body of evidence shows that consumption of ultra-processed foods (UPF) is associated with a higher
risk of cardiometabolic diseases, which, in turn, have been linked to depression. This suggests that UPF might also be asso-
ciated with depression, which is among the global leading causes of disability and disease. We prospectively evaluated the
relationship between UPF consumption and the risk of depression in a Mediterranean cohort.
Methods We included 14,907 Spanish university graduates [mean (SD) age: 36.7 year (11.7)] initially free of depression
who were followed up for a median of 10.3 years. Consumption of UPF (industrial formulations made mostly or entirely
from substances derived from foods and additives, with little, if any, intact food), as defned by the NOVA food classifcation
system, was assessed at baseline through a validated semi-quantitative 136-item food-frequency questionnaire. Participants
were classifed as incident cases of depression if they reported a medical diagnosis of depression or the habitual use of
antidepressant medication in at least one of the follow-up assessments conducted after the frst 2 years of follow-up. Cox
regression models were used to assess the relationship between UPF consumption and depression incidence.
Results A total of 774 incident cases of depression were identifed during follow-up. Participants in the highest quartile of
UPF consumption had a higher risk of developing depression [HR (95% CI) 1.33 (1.07–1.64); p trend=0.004] than those
in the lowest quartile after adjusting for potential confounders.
Conclusions In a prospective cohort of Spanish university graduates, we found a positive association between UPF consump-
tion and the risk of depression that was strongest among participants with low levels of physical activity
Use of non-steroidal anti-inflammatory drugs, aspirin and the risk of depression: The "Seguimiento Universidad de Navarra (SUN)" cohort.
Background: The potential effect of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) to prevent depression
remains largely unknown, in spite of the implication of inflammation in depression. This study aimed to investigate whether the habitual intake of aspirin and other NSAIDs was prospectively associated with a reduction
in the observed incidence of depression.
Methods: A dynamic cohort including 22,564 Spanish university graduates (mean age: 37 years) initially free of
depression was followed during an average of 8.7 years. Exposure to NSAIDs was assessed with specific repeated
questionnaires throughout follow-up, starting in the 2-year follow-up questionnaire. Incident cases of depression
were defined as either a new validated medical diagnosis of depression or reporting the initiation of habitual use
of antidepressants.
Results: We identified 772 incident cases of depression. Regular intake of aspirin and other NSAIDs was not
associated with depression risk. Only in secondary sensitivity analyses using a definition of the outcome with
higher specificity (a validated medical diagnosis of depression), an inverse association of aspirin with depression
was found [HR (95%CI): 0.20 (0.04–0.87)]. However, these results were non-significant after adjustment for
multiple testing.
Limitations: A possible underestimation of incident depression and a limited ability to detect all possible residual
confounding.
Conclusions: Regular use of NSAIDs was not associated with the incidence of depression. Further longitudinal
controlled studies are necessary to clarify a potential role of aspirin use in depression risk