Simulation and Analysis Chain for Acoustic Ultra-high Energy Neutrino Detectors in Water

Acousticneutrinodetectionisapromisingapproachforlarge-scaleultra-highenergyneutrinodetectorsinwater.In this article, a Monte Carlo simulation chain for acoustic neutrino detection devices in water will be presented. The simulation chain covers the generation of the acoustic pulse produced by a neutrino interaction and its propagation to the sensors within the detector. Currently, ambient and transient noise models for the Mediterranean Sea and simulations of the data acquisition hardware, equivalent to the one used in ANTARES/AMADEUS, are implemented. A pre-selection scheme for neutrino-like signals based on matched filtering is employed, as it is used for on-line filtering. To simulate the whole processing chain for experimental data, signal classification and acoustic source reconstruction algorithms are integrated in an analysis chain. An overview of design and capabilities of the simulation and analysis chain will be presented and preliminary studies will be discussed.Comment: 6 pages, 5 figures, ARENA 2012. arXiv admin note: substantial text overlap with arXiv:1304.057

Functional Relaxation and Guided Imagery as Complementary Therapy in Asthma: A Randomized Controlled Clinical Trial

Background: Asthma is a frequently disabling and almost invariably distressing disease that has a high overall prevalence. Although relaxation techniques and hypnotherapeutic interventions have proven their effectiveness in numerous trials, relaxation therapies are still not recommended in treatment guidelines due to a lack of methodological quality in many of the trials. Therefore, this study aims to investigate the efficacy of the brief relaxation technique of functional relaxation (FR) and guided imagery (GI) in adult asthmatics in a randomized controlled trial. Methods: 64 patients with extrinsic bronchial asthma were treated over a 4-week period and assessed at baseline, after treatment and after 4 months, for follow-up. 16 patients completed FR, 14 GI, 15 both FR and GI (FR/GI) and 13 received a placebo relaxation technique as the control intervention (CI). The forced expiratory volume in the first second (FEV 1) as well as the specific airway resistance (sR(aw)) were employed as primary outcome measures. Results: Participation in FR, GI and FR/GI led to increases in FEV 1 (% predicted) of 7.6 +/- 13.2, 3.3 +/- 9.8, and 8.3 +/- 21.0, respectively, as compared to -1.8 +/- 11.1 in the CI group at the end of the therapy. After follow-up, the increases in FEV 1 were 6.9 +/- 10.3 in the FR group, 4.4 +/- 7.3 in the GI and 4.5 +/- 8.1 in the FR/GI, compared to -2.8 +/- 9.2 in the CI. Improvements in sR(aw) (% predicted) were in keeping with the changes in FEV 1 in all groups. Conclusions: Our study confirms a positive effect of FR on respiratory parameters and suggests a clinically relevant long-term benefit from FR as a nonpharmacological and complementary therapy treatment option. Copyright (C) 2009 S. Karger AG, Base

Development of Combined Opto-Acoustical Sensor Modules

The faint fluxes of cosmic neutrinos expected at very high energies require large instrumented detector volumes. The necessary volumes in combination with a sufficient shielding against background constitute forbidding and complex environments (e.g. the deep sea) as sites for neutrino telescopes. To withstand these environments and to assure the data quality, the sensors have to be reliable and their operation has to be as simple as possible. A compact sensor module design including all necessary components for data acquisition and module calibration would simplify the detector mechanics and ensures the long term operability of the detector. The compact design discussed here combines optical and acoustical sensors inside one module, therefore reducing electronics and additional external instruments for calibration purposes. In this design the acoustical sensor is primary used for acoustic positioning of the module. The module may also be used for acoustic particle detection and marine science if an appropriate acoustical sensor is chosen. First tests of this design are promising concerning the task of calibration. To expand the field of application also towards acoustic particle detection further improvements concerning electromagnetic shielding and adaptation of the single components are necessary.Comment: 4 pages, 2 figures, ARENA2010 proceeding

Reconstruction methods for acoustic particle detection in the deep sea using clusters of hydrophones

This article focuses on techniques for acoustic noise reduction, signal filters and source reconstruction. For noise reduction, bandpass filters and cross correlations are found to be efficient and fast ways to improve the signal to noise ratio and identify a possible neutrino-induced acoustic signal. The reconstruction of the position of an acoustic point source in the sea is performed by using small-volume clusters of hydrophones (about 1 cubic meter) for direction reconstruction by a beamforming algorithm. The directional information from a number of such clusters allows for position reconstruction. The algorithms for data filtering, direction and position reconstruction are explained and demonstrated using simulated data.Comment: 7 pages, 13 figure

Psychotherapy in dizziness: a systematic review

About 30-50% of complex dizziness disorders are organically not sufficiently explained or related to a psychiatric disorder. Of patients with such dizziness disorders, 80% are severely impaired by dizziness in their daily and working lives; nevertheless, they are often not diagnosed or treated adequately

Blood Processing Technologies for Cryopreserved Transfusion Products and Extracorporeal Treatment Applications

There is a significant need for technological advancement in blood processing. New technologies in rapid processing of frozen blood products could significantly improve management of the blood supply chain in the United States by enabling on-demand use of frozen blood products that can be stored for 10 years instead of the current 6 weeks of refrigerated shelf life. In addition, advancements in blood processing for the extracorporeal treatment of sepsis could potentially save over 100,000 lives every year in the United States alone. Here we describe a new mathematical modeling approach for the design of procedures to rapidly remove the cryoprotectant glycerol from frozen-thawed red blood cells. We employ a concentration dependent permeability parameter to account for the varied glycerol transport rates of red blood cells over the wide range of glycerol concentrations encountered during deglycerolization. Additionally, variability of glycerol permeability is addressed by optimizing procedures to account for faster and slower responding cells within the population. These mathematically optimized procedures resulted in a significant reduction in hemolysis when compared to previous procedures that used a fixed value for permeability and did not account for cell variability. Our findings here indicate higher variability than anticipated within the cell population and between donors. Although ultra-rapid (< 1 min) removal of glycerol was not achieved, we achieved a significant reduction in processing times compared to the current standard. In addition to advancements in cryopreservation of blood products, new technologies were developed for applications in the extracorporeal treatment of sepsis. We presented a new hot embossing rapid prototyping approach for creation of high aspect ratio microfluidic devices in polycarbonate. We used a model system to test the effects of bifurcated microchannels on the removal of endotoxin from blood. We saw no significant effect of bifurcations on endotoxin removal, but reduction of channel width resulted in a significant increase in removal efficiency with up to 80% single pass clearance in the smallest width channel. This work forwards understanding on design of absorption-based blood perfusion devices to harness the unique flow properties of blood in microchannels

Position reconstruction of acoustic sources with the AMADEUS Detector

This article focuses on techniques for position reconstruction of acoustic point sources with the AMADEUS setup consisting of 36 acoustic sensors in the Mediterranean Sea. The direction reconstruction of an acoustic point source utilizes the information of the 6 small-volume hydrophone clusters of AMADEUS individually. Source position reconstruction is then done by combining the directional information of each cluster. The algorithms for direction and position reconstruction are explained and demonstrated using data taken in the deep sea.Comment: 4 pages, 7 figures, to appear in the proceedings of the 3rd International Workshop on the Acoustic and Radio EeV Neutrino detection Activities, Rome, Ital