One-step synthesis of hypoxanthine from glycinamide and diformylurea

Because of their easy availability and their relative chemical stability, urea, formic acid, and glycine might have played a role in the assembly process of nucleobases. In this paper, a short reaction path is described to prepare hypoxanthine starting from the above mentioned precursors. The formation of hypoxanthine has been verified by high-resolution mass spectrometry with the N-15-labelled urea as starting material, and HPLC analysis. The yield of this condensation reaction has been determined spectrophotometrically.status: publishe

Chemical synthesis of C-13 and N-15 labeled nucleosides

The chemical synthesis of C-13 and N-15 labeled nucleosides for site-specific incorporation in RNA or DNA oligonucleotides is herein reviewed. The review covers the following aspects: 1: single- and multiple site chemical C-13 and/or N-15 labeling of purine bases, 2: single- and multiple site chemical C-13 and/or N-15 labeling of pyrimidine bases, 3: single- and multiple site chemical C-13 labeling of the sugar residues.status: publishe

Glycosylation of 1-aminoimidazole-2 (3H)-thiones

The selectivity of the glycosylation of 1-aminoimidazole-2(3H)-thiones can be controlled. Depending on the chosen conditions, either the kinetically favored S-glycosides or the thermodynamically more stable N-glycosylated compounds are obtained in only one anomeric configuration (beta-anomer).status: publishe

Synthesis and leukemia cell growth inhibition of a series of 1,3-dithiazolylbenzene derivatives

By a slightly modified Hantzsch thiazole synthesis either 1,3-bis[(thiazol-2-yl) amino] benzene derivatives 2 or 1,3-bis[2-iminothiazol-3(2H)-yl] benzene derivatives 3 were exclusively obtained. The compounds can be distinguished by NMR spectroscopy. Compounds 2a - 2d and 3a - 3d were evaluated for their potential antitumor activity, DNA interaction, and for their activity against DNA and RNA viruses and against HIV-1 and HIV-2.status: publishe