433 research outputs found
Inactivation of the Bacterial Pathogens \u3cem\u3eStaphylococcus pseudintermedius\u3c/em\u3e and \u3cem\u3eAcinetobacter baumannii\u3c/em\u3e By Butanoic Acid
Aims
This study was performed to evaluate the efficacy of butanoic acid against bacterial pathogens including Acinetobacter baumannii and Staphylococcus pseudintermedius. Methods and Results
Vegetative bacteria were exposed to butanoic acid in vitro and log reduction was quantified using viable count assays. The maximum (8 and 9) log inactivation was determined by qualitatively assaying for growth/no-growth after a 48-h incubation (37°C). Membrane integrity after exposure to butanoic acid was determined by propidium iodide staining, scanning electron microscopy, membrane depolarization and inductively coupled plasma analysis. Cytosolic pH was measured by 5-(6-)carboxyfluorescein succinimidyl ester. Conclusions
Inhibitory concentrations of butanoic acid ranged between 11 and 21 mmol lâ1 for Gram-positive and Gram-negative species tested. The maximum log reduction of A. baumannii was achieved with a 10-s exposure of 0·50 mol lâ1 of butanoic acid. Staphylococcus pseudintermedius required 0·40 mol lâ1 of butanoic acid to achieve the same level of reduction in the same time period. Inactivation was associated with membrane permeability and acidification of the cytosol. Significance and Impact of the Study
Antibiotic resistance among bacterial pathogens necessitates the utilization of novel therapeutics for disinfection and biological control. These results may facilitate the development of butanoic acid as an effective agent against a broad-spectrum of antibiotic-resistant bacterial pathogens
SoLid : Search for Oscillations with Lithium-6 Detector at the SCK-CEN BR2 reactor
Sterile neutrinos have been considered as a possible explanation for the recent reactor and Gallium anomalies arising from reanalysis of reactor flux and calibration data of previous neutrino experiments. A way to test this hypothesis is to look for distortions of the anti-neutrino energy caused by oscillation from active to sterile neutrino at close stand-off (similar to 6-8m) of a compact reactor core. Due to the low rate of anti-neutrino interactions the main challenge in such measurement is to control the high level of gamma rays and neutron background.
The SoLid experiment is a proposal to search for active-to-sterile anti-neutrino oscillation at very short baseline of the SCK center dot CEN BR2 research reactor.
This experiment uses a novel approach to detect anti-neutrino with a highly segmented detector based on Lithium-6. With the combination of high granularity, high neutron-gamma discrimination using 6LiF:ZnS(Ag) and precise localization of the Inverse Beta Decay products, a better experimental sensitivity can be achieved compared to other state-of-the-art technology. This compact system requires minimum passive shielding allowing for very close stand off to the reactor. The experimental set up of the SoLid experiment and the BR2 reactor will be presented. The new principle of neutrino detection and the detector design with expected performance will be described. The expected sensitivity to new oscillations of the SoLid detector as well as the first measurements made with the 8 kg prototype detector deployed at the BR2 reactor in 2013-2014 will be reported
Observation and Characterization of a Cosmic Muon Neutrino Flux from the Northern Hemisphere using six years of IceCube data
The IceCube Collaboration has previously discovered a high-energy
astrophysical neutrino flux using neutrino events with interaction vertices
contained within the instrumented volume of the IceCube detector. We present a
complementary measurement using charged current muon neutrino events where the
interaction vertex can be outside this volume. As a consequence of the large
muon range the effective area is significantly larger but the field of view is
restricted to the Northern Hemisphere. IceCube data from 2009 through 2015 have
been analyzed using a likelihood approach based on the reconstructed muon
energy and zenith angle. At the highest neutrino energies between 191 TeV and
8.3 PeV a significant astrophysical contribution is observed, excluding a
purely atmospheric origin of these events at significance. The
data are well described by an isotropic, unbroken power law flux with a
normalization at 100 TeV neutrino energy of
and a hard spectral index of . The observed spectrum is
harder in comparison to previous IceCube analyses with lower energy thresholds
which may indicate a break in the astrophysical neutrino spectrum of unknown
origin. The highest energy event observed has a reconstructed muon energy of
which implies a probability of less than 0.005% for
this event to be of atmospheric origin. Analyzing the arrival directions of all
events with reconstructed muon energies above 200 TeV no correlation with known
-ray sources was found. Using the high statistics of atmospheric
neutrinos we report the currently best constraints on a prompt atmospheric muon
neutrino flux originating from charmed meson decays which is below in
units of the flux normalization of the model in Enberg et al. (2008).Comment: 20 pages, 21 figure
Lowering IceCubeâs energy threshold for point source searches in the southern sky
Observation of a point source of astrophysical neutrinos would be a "smoking gun" signature of a cosmic-ray accelerator. While IceCube has recently discovered a diffuse flux of astrophysical neutrinos, no localized point source has been observed. Previous IceCube searches for point sources in the southern sky were restricted by either an energy threshold above a few hundred TeV or poor neutrino angular resolution. Here we present a search for southern sky point sources with greatly improved sensitivities to neutrinos with energies below 100 TeV. By selecting charged-current nu(mu) interacting inside the detector, we reduce the atmospheric background while retaining efficiency for astrophysical neutrino-induced events reconstructed with sub-degree angular resolution. The new event sample covers three years of detector data and leads to a factor of 10 improvement in sensitivity to point sources emitting below 100 TeV in the southern sky. No statistically significant evidence of point sources was found, and upper limits are set on neutrino emission from individual sources. A posteriori analysis of the highest-energy (similar to 100 TeV) starting event in the sample found that this event alone represents a 2.8 sigma deviation from the hypothesis that the data consists only of atmospheric background
The contribution of Fermi-2LAC blazars to the diffuse TeV-PeV neutrino flux
The recent discovery of a diffuse cosmic neutrino flux extending up to PeV
energies raises the question of which astrophysical sources generate this
signal. One class of extragalactic sources which may produce such high-energy
neutrinos are blazars. We present a likelihood analysis searching for
cumulative neutrino emission from blazars in the 2nd Fermi-LAT AGN catalogue
(2LAC) using an IceCube neutrino dataset 2009-12 which was optimised for the
detection of individual sources. In contrast to previous searches with IceCube,
the populations investigated contain up to hundreds of sources, the largest one
being the entire blazar sample in the 2LAC catalogue. No significant excess is
observed and upper limits for the cumulative flux from these populations are
obtained. These constrain the maximum contribution of the 2LAC blazars to the
observed astrophysical neutrino flux to be or less between around 10
TeV and 2 PeV, assuming equipartition of flavours at Earth and a single
power-law spectrum with a spectral index of . We can still exclude that
the 2LAC blazars (and sub-populations) emit more than of the observed
neutrinos up to a spectral index as hard as in the same energy range.
Our result takes into account that the neutrino source count distribution is
unknown, and it does not assume strict proportionality of the neutrino flux to
the measured 2LAC -ray signal for each source. Additionally, we
constrain recent models for neutrino emission by blazars.Comment: 18 pages, 22 figure
All-sky search for time-integrated neutrino emission from astrophysical sources with 7 years of IceCube data
Since the recent detection of an astrophysical flux of high energy neutrinos,
the question of its origin has not yet fully been answered. Much of what is
known about this flux comes from a small event sample of high neutrino purity,
good energy resolution, but large angular uncertainties. In searches for
point-like sources, on the other hand, the best performance is given by using
large statistics and good angular reconstructions. Track-like muon events
produced in neutrino interactions satisfy these requirements. We present here
the results of searches for point-like sources with neutrinos using data
acquired by the IceCube detector over seven years from 2008--2015. The
discovery potential of the analysis in the northern sky is now significantly
below , on average
lower than the sensitivity of the previously published analysis of four
years exposure. No significant clustering of neutrinos above background
expectation was observed, and implications for prominent neutrino source
candidates are discussed.Comment: 19 pages, 17 figures, 3 tables; ; submitted to The Astrophysical
Journa
Search for non-relativistic Magnetic Monopoles with IceCube
The IceCube Neutrino Observatory is a large Cherenkov detector instrumenting
of Antarctic ice. The detector can be used to search for
signatures of particle physics beyond the Standard Model. Here, we describe the
search for non-relativistic, magnetic monopoles as remnants of the GUT (Grand
Unified Theory) era shortly after the Big Bang. These monopoles may catalyze
the decay of nucleons via the Rubakov-Callan effect with a cross section
suggested to be in the range of to
. In IceCube, the Cherenkov light from nucleon decays
along the monopole trajectory would produce a characteristic hit pattern. This
paper presents the results of an analysis of first data taken from May 2011
until May 2012 with a dedicated slow-particle trigger for DeepCore, a
subdetector of IceCube. A second analysis provides better sensitivity for the
brightest non-relativistic monopoles using data taken from May 2009 until May
2010. In both analyses no monopole signal was observed. For catalysis cross
sections of the flux of non-relativistic
GUT monopoles is constrained up to a level of at a 90% confidence level,
which is three orders of magnitude below the Parker bound. The limits assume a
dominant decay of the proton into a positron and a neutral pion. These results
improve the current best experimental limits by one to two orders of magnitude,
for a wide range of assumed speeds and catalysis cross sections.Comment: 20 pages, 20 figure
A combined maximum-likelihood analysis of the high-energy astrophysical neutrino flux measured with IceCube
Evidence for an extraterrestrial flux of high-energy neutrinos has now been
found in multiple searches with the IceCube detector. The first solid evidence
was provided by a search for neutrino events with deposited energies
TeV and interaction vertices inside the instrumented volume. Recent
analyses suggest that the extraterrestrial flux extends to lower energies and
is also visible with throughgoing, -induced tracks from the Northern
hemisphere. Here, we combine the results from six different IceCube searches
for astrophysical neutrinos in a maximum-likelihood analysis. The combined
event sample features high-statistics samples of shower-like and track-like
events. The data are fit in up to three observables: energy, zenith angle and
event topology. Assuming the astrophysical neutrino flux to be isotropic and to
consist of equal flavors at Earth, the all-flavor spectrum with neutrino
energies between 25 TeV and 2.8 PeV is well described by an unbroken power law
with best-fit spectral index and a flux at 100 TeV of
.
Under the same assumptions, an unbroken power law with index is disfavored
with a significance of 3.8 () with respect to the best
fit. This significance is reduced to 2.1 () if instead we
compare the best fit to a spectrum with index that has an exponential
cut-off at high energies. Allowing the electron neutrino flux to deviate from
the other two flavors, we find a fraction of at Earth.
The sole production of electron neutrinos, which would be characteristic of
neutron-decay dominated sources, is rejected with a significance of 3.6
().Comment: 16 pages, 10 figures; accepted for publication in The Astrophysical
Journal; updated one referenc
The IceCube Neutrino Observatory - Contributions to ICRC 2015 Part II: Atmospheric and Astrophysical Diffuse Neutrino Searches of All Flavors
Papers on atmospheric and astrophysical diffuse neutrino searches of all
flavors submitted to the 34th International Cosmic Ray Conference (ICRC 2015,
The Hague) by the IceCube Collaboration.Comment: 66 pages, 36 figures, Papers submitted to the 34th International
Cosmic Ray Conference, The Hague 2015, v2 has a corrected author lis
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