1 research outputs found
Serious adverse events in patients with idiopathic pulmonary fibrosis in the placebo arms of 6 clinical trials
Background: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by irreversible
loss of lung function and an unpredictable course of disease progression.
Methods: The safety data for patients with IPF who received placebo in 6 clinical trials were pooled to examine
the categories and frequencies of serious adverse events (SAEs) in this population.
Results: In 1082 patients with IPF who received placebo, 673 SAEs were reported. Of these, 93 SAEs
resulted in death (8.6% of patients). Respiratory-related conditions were the most frequently reported
SAE (225 events, 16.33 per 100 patient-exposure years [PEY]), followed by infections and infestations
(136 events, 9.87 per 100 PEY) and cardiac disorders (79 events, 5.73 per 100 PEY); these categories also had
the most fatal outcomes (60, 10, and 10 deaths, respectively). The most frequently reported fatal respiratoryrelated SAEs were IPF and respiratory failure (38 and 11 patients, respectively), and the most frequently
reported fatal infections and infestations and cardiac disorders were pneumonia (5 patients) and myocardial
infarct