Die erkenning van die noodsaaklikheid van natuurbewaring ten opsigte van basiese grondgebruiksbeplanning in dierepubliek van Suid-Afrika

The concept of a natural resource is explained and nature conservation as a form of land use is discussed in some detail. Special reference is made to the National Physical Development of Planning and the Environment on the role played by nature conservation in basic usage of the soil as planned by the state in the Republic of South Africa

Determining the effect of three- dimensional printing orientation on the bending strength of sand moulds and cores when using a voxeljet additive manufacturing machine

Abstract: Advances made in Additive Manufacturing (AM) or 3D printing led to the 3D printing of sand moulds and cores used in the foundry industry. Ideally, the mechanical properties of the 3D printed moulds and cores should be uniform throughout the 3D printed part. This will ensure that the casting produced from the 3D printed mould has uniform properties throughout the mould. The following study investigated the effect of the printing location and part orientation in the AM machine used to produce the 3D Printed mould on the bending strength property of sand parts. Several printing orientations and angles were considered in the investigation. Descriptive statistics was used to assess and interpret the results

Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma.

Uveal melanoma (UM) is a rare cancer resulting from the transformation of melanocytes in the uveal tract. Integrative analysis has identified four molecular and clinical subsets of UM. To improve our molecular understanding of UM, we performed extensive multi-omics characterization comparing two aggressive UM patient-derived xenograft models with normal choroidal melanocytes, including DNA optical mapping, specific histone modifications, and DNA topology analysis using Hi-C. Our gene expression and cytogenetic analyses suggest that genomic instability is a hallmark of UM. We also identified a recurrent deletion in the BAP1 promoter resulting in loss of expression and associated with high risk of metastases in UM patients. Hi-C revealed chromatin topology changes associated with the upregulation of PRAME, an independent prognostic biomarker in UM, and a potential therapeutic target. Our findings illustrate how multi-omics approaches can improve our understanding of tumorigenesis and reveal two distinct mechanisms of gene expression dysregulation in UM