Prevalence and predictors of atypical histology in endometrial polyps removed by hysteroscopy: a secondary analysis from the SICMIG hysteroscopy trial

The aim of this study is to assess the prevalence of atypical hyperplasia (AH) and endometrial cancer (EC) within endometrial polyps (EPs) removed by hysteroscopy

Rethinking Biomedical Titanium Alloy Design:A Review of Challenges from Biological and Manufacturing Perspectives

Current biomedical titanium alloys have been repurposed from other industries, which has contributed to several biologically driven implant failure mechanisms. This review highlights the added value that may be gained by building an appreciation of implant biological responses at the onset of alloy design. Specifically, the fundamental mechanisms associated with immune response, angiogenesis, osseointegration and the potential threat of infection are discussed, including how elemental selection can modulate these pivotal systems. With a view to expedite inclusion of these interactions in alloy design criteria, methods to analyze these performance characteristics are also summarized. While machine learning techniques are being increasingly used to unearth complex relationships between alloying elements and material properties, much is still unknown about the correlation between composition and some bio-related properties. To bridge this gap, high-throughput methods are also reviewed to validate biological response along with cutting edge manufacturing approaches that may support rapid discovery. Taken together, this review encourages the alloy development community to rethink their approach to enable a new generation of biomedical implants intrinsically designed for a life in the body, including functionality to tackle biological challenges thereby offering improved patient outcomes.</p

Rethinking Biomedical Titanium Alloy Design: A Review of Challenges from Biological and Manufacturing Perspectives

Current biomedical titanium alloys have been repurposed from other industries, which has contributed to several biologically driven implant failure mechanisms. This review highlights the added value that may be gained by building an appreciation of implant biological responses at the onset of alloy design. Specifically, the fundamental mechanisms associated with immune response, angiogenesis, osseointegration and the potential threat of infection are discussed, including how elemental selection can modulate these pivotal systems. With a view to expedite inclusion of these interactions in alloy design criteria, methods to analyze these performance characteristics are also summarized. While machine learning techniques are being increasingly used to unearth complex relationships between alloying elements and material properties, much is still unknown about the correlation between composition and some bio-related properties. To bridge this gap, high-throughput methods are also reviewed to validate biological response along with cutting edge manufacturing approaches that may support rapid discovery. Taken together, this review encourages the alloy development community to rethink their approach to enable a new generation of biomedical implants intrinsically designed for a life in the body, including functionality to tackle biological challenges thereby offering improved patient outcomes

Accelerations in greater than intra-partum greater than cardiotocographic recording I. Correlation with perinatal outcome

The authors examine 1994 cardiotocographic recordings during labour, equivalent to 89% of all deliveries of the same period. They evaluate the tendency of the acceleratory activity in the single recordings during their whole lenght, comparing it with the perinatal outcome, evaluated by the perinatal mortality and the Apgar score at 1' and 5'. They conclude that the presence of accelerations could be considered, when present in a certain degree, a sure index of foetal well-being or of good possibility of foetal reactions to hypoxic stimuli, allowing a more cautious evaluation of the cardiotocogram

Accelerations in "intra-partum" cardiotocographic recording II. Present contemporaneously to prognostically unfavourable cardiotocographic aspects

The Authors examine 1994 cardiotocographic recordings during labour, equivalent to 89% of all deliveries of the same period. They evaluate the acceleratory activity in the tract of recording presenting alterations considered expression of foetal distress (bradycardia, severe tachycardia, loss of cyclic variations, variable and late decelerations), and compare both parameters with the perinatal outcome. The presence of accelerations seems to allow a more oculate evaluation of the cardiotocogram and, in particular, a decreased incidence of hurried instrumental foetal extractions