62 research outputs found
Maternal consumption of polyphenol-rich foods in late pregnancy and fetal ductus arteriosus flow dynamics
Sidestream cigarette smoke effects on cardiovascular responses in conscious rats: involvement of oxidative stress in the fourth cerebral ventricle
Background: Cigarette exposure increases brain oxidative stress. The literature showed that increased brain oxidative stress affects cardiovascular regulation. However, no previous study investigated the involvement of brain oxidative stress in animals exposed to cigarette and its relationship with cardiovascular regulation. We aimed to evaluate the effects of central catalase inhibition on baroreflex and cardiovascular responses in rats exposed to sidestream cigarette smoke (SSCS). Methods: We evaluated males Wistar rats (320-370 g), which were implanted with a stainless steel guide cannula into the fourth cerebral ventricle (4th V). Femoral artery and vein were cannulated for mean arterial pressure (MAP) and heart rate (HR) measurement and drug infusion, respectively. Rats were exposed to SSCS during three weeks, 180 minutes, 5 days/week (CO: 100-300 ppm). Baroreflex was tested with a pressor dose of phenylephrine (PHE, 8 mu g/kg, bolus) to induce bradycardic reflex and a depressor dose of sodium nitroprusside (SNP, 50 mu g/kg, bolus) to induce tachycardic reflex. Cardiovascular responses were evaluated before, 5, 15, 30 and 60 minutes after 3-amino-1,2,4-triazole (ATZ, catalase inhibitor, 0.001 g/100 mu L) injection into the 4th V. Results: Central catalase inhibition increased basal HR in the control group during the first 5 minutes. SSCS exposure increased basal HR and attenuated bradycardic peak during the first 15 minutes. Conclusion: We suggest that SSCS exposure affects cardiovascular regulation through its influence on catalase activity.Foundation of Support to Research of Sao Paulo State (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP [07/59127-9
FRA STORIA, MICROSTORIA E DISCUSSIONI IN RETE. La Grande Guerra degli Immigranti "Americani" (1914-1918)
Produtividade de milho adubado com composto de lodo de esgoto e fosfato natural de Gafsa
Effects of the application of sewage sludge and petrochemical residue in maize culture as source of micro-nutrients on soils of Paraná state
Loss of macronutrients (N, P, K) in the hydrographic basin of the River Ivaí, an affluent of the River Paraná
Experimental design approach in recombinant protein expression: determining medium composition and induction conditions for expression of pneumolysin from Streptococcus pneumoniae in Escherichia coliand preliminary purification process
A.Barausse. T.A. Luchese, Professores em viagens. Um olhar transnacional para a e/imigração de professores italianos para o Rio Grande do Sul/Brasil (1875-1914)
Nacionalismos e escolarização: entre italianidade e brasilidade, disputas na educação dos ítalo-gauchos (RS, Brasil, 1930-1945)
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