Modified Generalized-Brillouin-Zone Theory with On-site Disorders

We study the characterization of the non-Hermitian skin effect (NHSE) in non-Hermitian systems with on-site disorder. We extend the application of generalized-Brillouin-zone (GBZ) theory to these systems. By proposing a modified GBZ theory, we give a faithfully description of the NHSE. For applications, we obtain a unified $\beta$ for system with long-range hopping, and explain the conventional-GBZ irrelevance of the magnetic suppression of the NHSE in the previous study.Comment: 7-pages, 3 figure

The contribution of Alu exons to the human proteome.

BackgroundAlu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important regulatory roles in modulating mRNA degradation or translational efficiency. However, the contribution of Alu exons to the human proteome remains unclear and controversial. The prevailing view is that exons derived from young repetitive elements, such as Alu elements, are restricted to regulatory functions and have not had adequate evolutionary time to be incorporated into stable, functional proteins.ResultsWe adopt a proteotranscriptomics approach to systematically assess the contribution of Alu exons to the human proteome. Using RNA sequencing, ribosome profiling, and proteomics data from human tissues and cell lines, we provide evidence for the translational activities of Alu exons and the presence of Alu exon derived peptides in human proteins. These Alu exon peptides represent species-specific protein differences between primates and other mammals, and in certain instances between humans and closely related primates. In the case of the RNA editing enzyme ADARB1, which contains an Alu exon peptide in its catalytic domain, RNA sequencing analyses of A-to-I editing demonstrate that both the Alu exon skipping and inclusion isoforms encode active enzymes. The Alu exon derived peptide may fine tune the overall editing activity and, in limited cases, the site selectivity of ADARB1 protein products.ConclusionsOur data indicate that Alu elements have contributed to the acquisition of novel protein sequences during primate and human evolution

Short-Term Efficacy of Laparoscopic Treatment for Colorectal Cancer in Patients with Schistosomiasis Japonica

Introduction. Schistosomiasis is associated with numerous complications such as thrombocytopenia, liver cirrhosis, portal hypertension, and colitis. To the best of our knowledge, the feasibility and outcomes of laparoscopic colorectal surgery in patients with schistosomiasis have not yet been studied. Methods. In this study, the data of 280 patients with colorectal carcinoma along with schistosomiasis japonica infection who underwent laparoscopic or open colorectal surgery were retrospectively analyzed. Preoperative data, operative data, pathological outcomes, postoperative complications, and recovery were compared between patients in the laparoscopic (LAC) and open (OC) groups. Results. There were no significant differences in the preoperative data between the groups. However, fewer postoperative complications, especially severe hypoproteinemia, early postoperative feeding, and shorter postoperative hospital stay, were observed in patients in the LAC group (P<0.001). The mean operative time was higher in the LAC group (180 min versus 158 min; P<0.001), while the mean blood loss was similar (95 mL versus 108 mL; P=0.196) between groups. The mean number of lymph nodes harvested was also similar in both groups (15 versus 16; P=0.133). Conclusion. Laparoscopic surgery for colorectal cancer is safe in patients with schistosomiasis japonica and has better short-term outcomes than open surgery

Struma ovarii associated with pseudo-Meigs' syndrome and elevated serum CA 125: a case report and review of the literature

The association of pseudo-Meigs' syndrome, elevation of CA 125 to the struma ovarii is a rare condition. So far only nine cases have been reported in English literature through MEDLINE search. Here we report a 46-year-old case of the struma ovarii, presented with ascites, hydrothorax, right ovarian mass and elevated serum CA 125 level. These findings were misdiagnosed for an ovarian malignancy at the first impression. Immediate resolution of the ascites, hydrothorax and normalization of the serum CA 125 level were followed by ovarian mass removal. Struma ovarii could be a rare cause of ascites, hydrothorax, ovarian mass and elevated CA 125. This rare condition should be considered in the differential diagnosis in patents with ascites and pleural effusions but with negative cytology

MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells.

Pancreatic adenocarcinoma is one of the most leading causes of cancer-related deaths worldwide. Although recent advances provide various treatment options, pancreatic adenocarcinoma has poor prognosis due to its late diagnosis and ineffective therapeutic multimodality. Gemcitabine is the effective first-line drug in pancreatic adenocarcinoma treatment. However, gemcitabine chemoresistance of pancreatic adenocarcinoma cells has been a major obstacle for limiting its treatment effect. Our study found that p70S6K1 plays an important role in gemcitabine chemoresistence. MiR-145 is a tumor suppressor which directly targets p70S6K1 for inhibiting its expression in pancreatic adenocarcinoma, providing new therapeutic scheme. Our findings revealed a new mechanism underlying gemcitabine chemoresistance in pancreatic adenocarcinoma cells

Brusatol

The title compound, C26H32O11, is composed of an α,β-unsaturated cyclo­hexa­none ring (A), two cyclo­hexane rings (B and C), a six-membered lactone ring (D) and tetra­hydro­furan ring (E). Ring A exists in a half-chair conformation with a C atom displaced by 0.679 (2) Å from the mean plane through the remaining five atoms. Ring B exists in a normal chair conformation. Both rings C and D exist in a twisted-chair conformation due to the O-atom bridge and the carbonyl group in rings C and D, respectively. Ring E shows an envelope conformation with a C atom displaced by 0.761 (1) Å from the mean plane through the remaining five atoms. The ring junctions are A/B trans, B/C trans, C/D cis and D/E cis. An intra­molecular O—H⋯O hydrogen bond occurs. In the crystal, O—H⋯O hydrogen bonds involving the hy­droxy, lactone and ester groups and C—H⋯O inter­actions are observed

Kinematics and Collimation of the Two-Sided Jets in NGC 4261: VLBI Study on Sub-parsec Scales

We report multi-frequency VLBI studies of the sub-parsec scale structure of the two-sided jet in the nearby radio galaxy NGC 4261. Our analyses include new observations using the Source Frequency Phase Referencing technique with the Very Long Baseline Array at 44 and 88 GHz, as well as archival data at 15 and 43 GHz. Our results show an extended double-sided structure at 43/44 GHz and provide a clear image of the nuclear region at 88 GHz, showing a core size of $\sim$0.09 mas and a brightness temperature of $\sim1.3\times10^{9}$ K. Proper motions are measured for the first time in the two-sided jet, with apparent speeds ranging from $0.31\pm0.14\,c$ to $0.59\pm0.40\,c$ in the approaching jet and $0.32\pm0.14\,c$ in the receding jet. The jet-to-counter-jet brightness ratio allows us to constrain the viewing angle to between $\sim54^{\circ}$ and $84^{\circ}$ and the intrinsic speed to between $\sim0.30\,c$ and $0.55\,c$. We confirm the parabolic shape of the upstream jet on both sides of the central engine, with a power-law index of $0.56\pm0.07$. Notably, the jet collimation is found to be already completed at sub-parsec scales, with a transition location of about 0.61 pc, which is significantly smaller than the Bondi radius of 99.2 pc. This behavior can be interpreted as the initial confinement of the jet by external pressure from either the geometrically thick, optically thin advection-dominated accretion flows (ADAF) or the disk wind launched from it. Alternatively, the shape transition may also be explained by the internal flow transition from a magnetically dominated to a particle-dominated regime.Comment: 9 pages, 5 figures, 2 table