Muscle protein metabolism in neonatal alloxan-administered rats: effects of continuous and intermittent swimming training

<p>Abstract</p> <p>Background</p> <p>This study aimed to examine the effects of intermittent and continuous swimming training on muscle protein metabolism in neonatal alloxan-administered rats.</p> <p>Methods</p> <p>Wistar rats were used and divided into six groups: sedentary alloxan (SA), sedentary control (SC), continuous trained alloxan (CA), intermittent trained alloxan (IA), continuous trained control (CC) and intermittent trained control (IC). Alloxan (250 mg/kg body weight) was injected into newborn rats at 6 days of age. The continuous training protocol consisted of 12 weeks of swimming training in individual cylinder tanks while supporting a load that was 5% of body weight; uninterrupted swimming for 1 h/day, five days a week. The intermittent training protocol consisted of 12 weeks of swimming training in individual cylinder tanks while supporting a load that was 15% of body weight; 30 s of activity interrupted by 30 s of rest for a total of 20 min/day, five days a week.</p> <p>Results</p> <p>At 28 days, the alloxan animals displayed higher glycemia after glucose overload than the control animals. No differences in insulinemia among the groups were detected. At 120 days, no differences in serum albumin and total protein among the groups were observed. Compared to the other groups, DNA concentrations were higher in the alloxan animals that were subjected to continuous training, whereas the DNA/protein ratio was higher in the alloxan animals that were subjected to intermittent training.</p> <p>Conclusion</p> <p>It was concluded that continuous and intermittent training sessions were effective in altering muscle growth by hyperplasia and hypertrophy, respectively, in alloxan-administered animals.</p

Efeito da dieta hipoenergética sobre a composição corporal e nível sérico lipídico de mulheres adultas com sobrepeso Effect of a low-energy diet on the body composition and serum lipid levels of overweight adult women

OBJETIVO: Verificar o efeito de 12 semanas de dieta hipocalórica sobre a composição corporal e o nível sérico lipídico de mulheres adultas com sobrepeso. MÉTODOS: A amostra foi composta por vinte mulheres (23,80, desvio-padrão de 2,73 anos) da academia Westfit-Bangu, divididas randomicamente em dois grupos de dez: grupo controle e grupo dieta hipoenergética. Foi realizada uma avaliação da composição corporal (massa corporal, percentual de gordura, índice de massa corporal e massa magra) e do nível sérico lipídico (colesterol total, triglicerídeos, lipoproteína de baixa densidade, lipoproteína de alta densidade e lipoproteínas de muito baixa densidade). Utilizou-se a estatística descritiva (média e desvio-padrão) e o teste t de Student na análise inter e intragrupos. O nível de significância foi de p<0,05. RESULTADOS: O grupo dieta hipoenergética apresentou reduções significativas (p<0,05) nas variáveis antropométricas (massa corporal, percentual de gordura, índice de massa corporal e massa magra) e nas variáveis lipídicas (triglicerídios, colesterol total, lipoproteína de baixa densidade e lipoproteínas de muito baixa densidade). Quanto à variável: lipoproteína de alta densidade, foi observada uma redução, porém não significativa. CONCLUSÃO: A partir dos resultados apresentados pode-se concluir que a dieta hipoenergética foi uma excelente opção no tratamento da obesidade e no controle do nível sérico dos lipídeos, contribuindo desta forma, para a redução dos riscos cardiovasculares na população estudada.<br>OBJECTIVE: This study verified the effects of a 12-week low-calorie diet on the body composition and serum lipid levels of overweight adult women. METHODS: The sample consisted of 20 females (23.80 years with a standard deviation of 2.73 years) of the Westfit-Bangu gym. They were randomly divided into two groups of ten: the Control Group and the Diet Group. Body composition (body mass, %fat, body mass index and lean body mass) and serum lipid levels (total cholesterol, triglycerides and high-, low- and very low-density lipoproteins) were assessed. Descriptive (central tendency and dispersion) and inferential statistics (Student's t-test) were used for inter and intragroup analysis. The significance level was set at p<0.05. RESULTS: The Diet Group presented a significant decrease (p<0.05) in anthropometric variables (body mass, % of fat, BMI and lean mass) and serum lipids (triglycerides, total cholesterol and low- and very low-density lipoproteins). The level of high-density lipoprotein also decreased but not significantly. CONCLUSION: In conclusion, the low-calorie diet was an excellent option for the treatment of obesity and to control serum lipid levels, decreasing the cardiovascular risk of the studied population