10 research outputs found
Immunocytochemical evidence for the presence of gamma 1-MSH-like immunoreactivity in pituitary corticotrophs and ACTH-producing tumours.
The presence of gamma 1-MSH has been demonstrated in bovine neuro-intermediate
lobe by biochemical methods, thus suggesting that this peptide is cleaved from
the cryptic region of pro-opiocortin. In this study we report the localisation of
gamma 1-MSH-like immunoreactivity in the adenohypophysis of man, ox, pig, dog and
guinea-pig using immunocytochemical procedures at both light and electron
microscope levels. Antisera recognising the C-terminal Arg-Phe-amide and the
C-terminal penta-peptide-amide of gamma 1-MSH have been used throughout this
study. The immunostaining was found in all endocrine cells of the pars intermedia
(where present) and in scattered cells of the pars distalis identified as
corticotrophs. No gamma 1-MSH immunoreactivity was detected in rat
adenohypophysis. In addition, 7 ACTH-producing tumours (1 pituitary adenoma and 6
ectopic) were investigated and shown to contain gamma 1-MSH immunoreactive cells
Impact of local- and regional-scale restoration measures on a vulnerable rich fen in the Naardermeer nature reserve (the Netherlands)
Heterochronies in the formation of the nervous and digestive systems in early postlarval development of opisthobranch mollusks: Organization of major organ systems of the arctic dorid Cadlina laevis
Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons
Stanozolol Decreases Bone Turnover Markers, Increases Mineralization, and Alters Femoral Geometry in Male Rats
Neurotrophic factors and target-specific retrograde signaling interactions define the specificity of classical and neuropeptide cotransmitter release at identified Lymnaea synapses
Sex differences in Sjögren's syndrome: A comprehensive review of immune mechanisms
Autoimmune diseases (ADs) are estimated to affect between 5 and 8 % of the US population, and approximately 80 % of these patients are women. Sjögren's syndrome (SS) is an AD that occurs predominately in women over men (16:1). The hallmark characteristic of SS is diminished secretory production from the primary exocrine gland and the lacrimal or salivary glands resulting in symptoms of dry eye and mouth. The disease is believed to be mediated by an inflammatory and autoantibody response directed against salivary and lacrimal gland tissues. This review will examine the literature on sex differences in the immune response of patients and animal models of Sjögren's syndrome in order to gain a better understanding of disease pathogenesis