Introduction by Guest Editors

This book grew out of conversations among the three guest editors, Mark Cammack, Michael Feener, and Clark Lombardi, in the summer of 2008 about the general lack of attention among scholars of Southeast Asian Islam on important questions about the foundations of the region’s Islamic legal structures. First, despite its evident importance, there has been little research on the process by which legislators and judges decide which interpretation of Islamic law will be formally applied by the state apparatus. Another important question that has been largely ignored by scholars concerns the qualifications of Islamic legal professionals. The three Southeast Asian states treated in this volume—Indonesia, Malaysia and Singapore—have separate systems of Islamic courts. Although the educational background of those who staff these courts will clearly inform the way they understand, interpret, and apply the law, to date little research has been done on the educational processes by which judges who serve on Islamic courts are trained to think about Islamic law. Studies on the means by which judges are appointed and regulated have also been lacking—even though the decision to favor one type of candidate surely affects the interpretation and application of Islamic law in the courts. Finally, lawyers who practice before Islamic courts play a crucial role in framing and presenting the issues for decision and in mediating between the courts that apply Islamic law and the public who have recourse to the state’s official Islamic legal institutions, but research on the professional training and governance of these lawyers is almost entirely lackin

Phase Rotation, Cooling And Acceleration Of Muon Beams: A Comparison Of Different Approaches

Experimental and theoretical activities are underway at CERN with the aim of examining the feasibility of a very-high-flux neutrino source. In the present scheme, a high-power proton beam (some 4 MW) bombards a target where pions are produced. The pions are collected and decay to muons under controlled optical condition. The muons are cooled and accelerated to a final energy of 50 GeV before being injected into a decay ring where they decay under well-defined conditions of energy and emittance. We present the most challenging parts of the whole scenario, the muon capture, the ionisation-cooling and the first stage of the muon acceleration. Different schemes, their performance and the technical challenges are compared.Comment: LINAC 2000 CONFERENCE, paper ID No. THC1

Applications of physical modeling to the investigations of air pollution problems in urban areas

CER73-74JEC-DJL-RST36.March 1974.Sponsored by National Science Foundation.Includes bibliographical references.Wind tunnel modeling of atmospheric flow and diffusion in the boundary layer over an urban area are discussed. Measurements were made over a model of an urban area composed of a network of uniform city blocks and streets. Two line sources emitting a radioactive tracer gas represented automobile emissions in a one-block length of a city street. Pollutant concentrations were calculated from samples of the tracer gas collected on building faces, in street canyons, and in the flow field above the model. Non dimensionalized concentration patterns were constructed from the analysis of the samples. Three wind directions were considered. The effects of a simple modification of the uniform model were evaluated.Under grant GI-34813X

Analysis of Foreign Trade with the Main Categories of Agro-Food Products, Parallel Romania - Italy

This paper aims to study the dynamics and structure of foreign trade in agro-food products according to the combined nomenclature of Romania and Italy. In this regard, with the help of statistical data taken from databases: the National Institute of Statistics, for Romania, and the International Trade Center, for Italy, the dynamics of exports, imports, and, at the same time, the trade balance were analysed. The degree of concentration of both imported and exported products was further analysed to determine whether or not there was a concentration on a particular chapter of the Combined Nomenclature

Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model

B cells have been reported to promote graft rejection through alloantibody production. However, there is growing evidence that B cells can contribute to the maintenance of tolerance. Here, we used a mouse model of MHC-class I mismatched skin transplantation to investigate the contribution of B cells to graft survival. We demonstrate that adoptive transfer of B cells prolongs skin graft survival but only when the B cells were isolated from mice housed in low sterility "conventional" (CV) facilities and not from mice housed in pathogen free facilities (SPF). However, prolongation of skin graft survival was lost when B cells were isolated from IL-10 deficient mice housed in CV facilities. The suppressive function of B cells isolated from mice housed in CV facilities correlated with an anti-inflammatory environment and with the presence of a different gut microflora compared to mice maintained in SPF facilities. Treatment of mice in the CV facility with antibiotics abrogated the regulatory capacity of B cells. Finally, we identified transitional B cells isolated from CV facilities as possessing the regulatory function. These findings demonstrate that B cells, and in particular transitional B cells, can promote prolongation of graft survival, a function dependent on licensing by gut microflora

Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44.

Sulfatase modifying factor 1 (SUMF1) encodes for the formylglicine generating enzyme, which activates sulfatases by modifying a key cysteine residue within their catalytic domains. SUMF1 is mutated in patients affected by multiple sulfatase deficiency, a rare recessive disorder in which all sulfatase activities are impaired. Despite the absence of canonical retention/retrieval signals, SUMF1 is largely retained in the endoplasmic reticulum (ER), where it exerts its enzymatic activity on nascent sulfatases. Part of SUMF1 is secreted and paracrinally taken up by distant cells. Here we show that SUMF1 interacts with protein disulfide isomerase (PDI) and ERp44, two thioredoxin family members residing in the early secretory pathway, and with ERGIC-53, a lectin that shuttles between the ER and the Golgi. Functional assays reveal that these interactions are crucial for controlling SUMF1 traffic and function. PDI couples SUMF1 retention and activation in the ER. ERGIC-53 and ERp44 act downstream, favoring SUMF1 export from and retrieval to the ER, respectively. Silencing ERGIC-53 causes proteasomal degradation of SUMF1, while down-regulating ERp44 promotes its secretion. When over-expressed, each of three interactors favors intracellular accumulation. Our results reveal a multistep control of SUMF1 trafficking, with sequential interactions dynamically determining ER localization, activity and secretion

Biofilms: Novel strategies based on antimicrobial peptides

The problem of drug resistance is very worrying and ever increasing. Resistance is due not only to the reckless use of antibiotics but also to the fact that pathogens are able to adapt to different conditions and develop self-defense mechanisms such as living in biofilms; altogether these issues make the search for alternative drugs a real challenge. Antimicrobial peptides appear as promising alternatives but they have disadvantages that do not make them easily applicable in the medical field; thus many researches look for solutions to overcome the disadvantages and ensure that the advantages can be exploited. This review describes the biofilm characteristics and identifies the key features that antimicrobial peptides should have. Recalcitrant bacterial infections caused by the most obstinate bacterial species should be treated with a strategy to combine conventional peptides functionalized with nano-tools. This approach could effectively disrupt high density infections caused by biofilms. Moreover, the importance of using in vivo non mammalian models for biofilm studies is described. In particular, here we analyze the use of amphibians as a model to substitute the rodent model

The spectral form factor is not self-averaging

The spectral form factor, k(t), is the Fourier transform of the two level correlation function C(x), which is the averaged probability for finding two energy levels spaced x mean level spacings apart. The average is over a piece of the spectrum of width W in the neighborhood of energy E0. An additional ensemble average is traditionally carried out, as in random matrix theory. Recently a theoretical calculation of k(t) for a single system, with an energy average only, found interesting nonuniversal semiclassical effects at times t approximately unity in units of {Planck's constant) /(mean level spacing). This is of great interest if k(t) is self-averaging, i.e, if the properties of a typical member of the ensemble are the same as the ensemble average properties. We here argue that this is not always the case, and that for many important systems an ensemble average is essential to see detailed properties of k(t). In other systems, notably the Riemann zeta function, it is likely possible to see the properties by an analysis of the spectrum.Comment: 4 pages, RevTex, no figures, submitted to Phys. Rev. Lett., permanent e-mail address, [email protected]