Epigenetic modulators as therapeutic targets in prostate cancer

Prostate cancer is one of the most common non-cutaneous malignancies among men worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or histone modifications, are key drivers of prostate carcinogenesis. These epigenetic defects might be due to deregulated function and/or expression of the epigenetic machinery, affecting the expression of several important genes. Remarkably, epigenetic modifications are reversible and numerous compounds that target the epigenetic enzymes and regulatory proteins were reported to be effective in cancer growth control. In fact, some of these drugs are already being tested in clinical trials. This review discusses the most important epigenetic alterations in prostate cancer, highlighting the role of epigenetic modulating compounds in pre-clinical and clinical trials as potential therapeutic agents for prostate cancer management.info:eu-repo/semantics/publishedVersio

Microbiological and Chemical Characterisation of Composts at Different Levels of Maturity, with Evaluation of Phytotoxicity and Enzymatic Activities

Composts from different vegetable residues as well as pig and horse manure at different levels of maturity were used in the present study. In order to characterise the different composts, microbial populations (namely, total aerobic bacteria, actinomycetes, filamentous eumycetes, aerobic cellulolytic fungi and bacteria), physicochemical and chemical parameters (moisture, organic matter, total nitrogen, ammonium nitrogen, C:N ratio, pH, electrical conductivity), self-heating capacity and phytotoxicity (measured by means of the germination test with Lepidium sativion), as well as enzymatic activities [cellulase, lipase (C10), proteasel, were evaluated. The research was designed to focus on a possible correlation between the enzymatic activities and the maturity level of composts. The results showed evidence that the protease:cellulase activity ratio was significantly correlated to the compost phytotoxicity