Evidence for a narrow baryonic state decaying to K0Sp and KOSp in deep inelastic scattering at HERA

A resonance search has been made in the K0Sp and KOSp invariant-mass spectrum measured with the ZEUS detector at HERA using an integrated luminosity of 121 pb−1. The search was performed in the central rapidity region of inclusive deep inelastic scattering at an ep centre-of-mass energy of 300–318 GeV for exchanged photon virtuality, Q2, above 1 GeV2. Recent results from fixed-target experiments give evidence for a narrow baryon resonance decaying to K+n and K0Sp, interpreted as a pentaquark. The results presented here support the existence of such state, with a mass of 1521.5±1.5(stat.)+2.8−1.7(syst.) MeV and a Gaussian width consistent with the experimental resolution of 2 MeV. The signal is visible at high Q2 and, for Q2>20 GeV2, contains 221±48 events. The probability of a similar signal anywhere in the range 1500–1560 MeV arising from fluctuations of the background is below 6×10−5

Search for QCD-instanton induced events in deep inelastic ep scattering at HERA

A search for QCD-instanton-induced events in deep inelastic ep scattering has been performed with the ZEUS detector at the HERA collider, using data corresponding to an integrated luminosity of 38 pb-1. A kinematic range defined by cuts on the photon virtuality, Q2 > 120 GeV2, and on the Bjorken scaling variable, x > 10-3, has been investigated. The QCD-instanton induced events were modelled by the Monte Carlo generator QCDINS. A background-independent, conservative 95% confidence level upper limit for the instanton cross section of 26 pb is obtained, to be compared with the theoretically expected value of 8.9 pb

Multijet production in neutral current deep inelastic scattering at HERA and determination of α_{s}

Multijet production rates in neutral current deep inelastic scattering have been measured in the range of exchanged boson virtualities 10 5 GeV and –1 < η_{LAB}^{jet} < 2.5. Next-to-leading-order QCD calculations describe the data well. The value of the strong coupling constant α_{s} (M_{z}), determined from the ratio of the trijet to dijet cross sections, is α_{s} (M_{z}) = 0.1179 ± 0.0013 (stat.)_{-0.0046}^{+0.0028}(exp.)_{-0.0046}^{+0.0028}(th.)

Forward jet production in deep inelastic ep scattering and low-x parton dynamics at HERA

Forward jet cross sections have been measured in neutral current deep inelastic scattering at low Bjorken-x with the ZEUS detector at HERA using an integrated luminosity of ${81.8 \rm pb}^{-1}$. Measurements are presented for inclusive forward jets as well as for forward jets accompanied by a dijet system. The explored phase space, with jet pseudorapidity up to 4.3 is expected to be particularly sensitive to the dynamics of QCD parton evolution at low x. The measurements are compared to fixed-order QCD calculations and to leading-order parton-shower Monte Carlo models

Jet production in charged current deep inelastic e⁺p scatteringat HERA

The production rates and substructure of jets have been studied in charged current deep inelastic e⁺p scattering for Q² > 200 GeV² with the ZEUS detector at HERA using an integrated luminosity of 110.5 pb⁻¹. Inclusive jet cross sections are presented for jets with transverse energies E_{T}^{jet} > 5 GeV. Measurements of the mean subjet multiplicity, 〈n_{sbj}〉, of the inclusive jet sample are presented. Predictions based on parton-shower Monte Carlo models and next-to-leading-order QCD calculations are compared to the measurements. The value of α_{s} (M_{z}), determined from 〈n_{sbj}〉 at y_{cut} = 10⁻² for jets with 25 < E_{T}^{jet} < 119 GeV, is α_{s} (M_{z}) = 0.1202 ± 0.0052 (stat.)_{-0.0019}^{+0.0060} (syst.)_{-0.0053}^{+0.0065} (th.). The mean subjet multiplicity as a function of Q² is found to be consistent with that measured in NC DIS

Platelet-derived extracellular vesicles in Huntington's disease.

The production and release of extracellular vesicles (EV) is a property shared by all eukaryotic cells and a phenomenon frequently exacerbated in pathological conditions. The protein cargo of EV, their cell type signature and availability in bodily fluids make them particularly appealing as biomarkers. We recently demonstrated that platelets, among all types of blood cells, contain the highest concentrations of the mutant huntingtin protein (mHtt)-the genetic product of Huntington's disease (HD), a neurodegenerative disorder which manifests in adulthood with a complex combination of motor, cognitive and psychiatric deficits. Herein, we used a cohort of 59 HD patients at all stages of the disease, including individuals in pre-manifest stages, and 54 healthy age- and sex-matched controls, to evaluate the potential of EV derived from platelets as a biomarker. We found that platelets of pre-manifest and manifest HD patients do not release more EV even if they are activated. Importantly, mHtt was not found within EV derived from platelets, despite them containing high levels of this protein. Correlation analyses also failed to reveal an association between the number of platelet-derived EV and the age of the patients, the number of CAG repeats, the Unified Huntington Disease Rating Scale total motor score, the Total Functional Capacity score or the Burden of Disease score. Our data would, therefore, suggest that EV derived from platelets with HD is not a valuable biomarker in HD.The study was funded by an operating grant from the Merck Sharpe & Dohme to F.C. who is also a recipient of a National Researcher career award from the Fonds de Recherche du Québec en santé (FRQS) providing salary support and operating funds. I.S.-A. was supported by a CIHR-Huntington Society of Canada postdoctoral fellowship. R.A.B. and S.L.M. are supported by a National Institute for Health Research (NIHR) award of a Biomedical Research Center to the University of Cambridge and Addenbrooke’s Hospital. E.B. is supported by the Canadian Institutes of Health Research. N.D. MD-MSc. also funded by CIHR and by Canadian Consortium on Neurodegeneration in Aging (CCNA). HLD and JPL hold a Desjardins scholarship from the Fondation du CHU de Québec. HLD hold a bourse d’excellence du Centre Thématique de Recherche en Neurosciences (CTRN) du CHU de Québec. The authors would like to thank all the students and staff who helped with the blood collections in Cambridge, Quebec City and Montreal and importantly, all patients and their families for being so generous with their time in participating to this stud

Study of the Pion Trajectory in the Photoproduction of Leading Neutrons at HERA

Energetic neutrons produced in ep collisions at HERA have been studied with the ZEUS detector in the photoproduction regime at a mean photon-proton center-of-mass energy of 220 GeV. The neutrons carry a large fraction 0.6

ДИАГНОСТИЧЕСКИЕ И ПРОГНОСТИЧЕСКИЕ ВОЗМОЖНОСТИ ДОППЛЕРОМЕТРИИ ПРИ ПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЯХ МАТКИ (ОБЗОР ЛИТЕРАТУРЫ)

This literature review provides clinical and experimental data on the possibility of using doppler in obstetrics and gynecology from the first day of the discovery of the Doppler effect in 1942 to the present. Discussion of the practical application of doppler to identify predictors of the different gynecological pathologies. Outlined the prospects for the use of three-dimensional energetic doppler of the common blood flow and this significantly increases the information content of the differential diagnosis of the pelvic organs diseases.В обзоре литературы приводится историческая справка о возможности использования допплерометрии с момента открытия эффекта Допплера в 1942 году по настоящее время. Обсуждаются вопросы практического применения допплерометрии в качестве предикторов пролиферативных заболеваний матки и придатков матки, а также перспективы применения трехмерной энергетической допплерографии и объёмного кровотока с целью повышения диагностической информативности

Bose-Einstein Correlations in One and Two Dimensions in Deep Inelastic Scattering

Bose-Einstein correlations in one and two dimensions have been studied in deep inelastic ep scattering events measured with the ZEUS detector at HERA using an integrated luminosity of 121 pb-1. The correlations are independent of the virtuality of the exchanged photon, Q2, in the range 0.1 \u3c Q2 \u3c 8000 GeV2. There is no significant difference between the correlations in the current and target regions of the Breit frame for Q2 \u3e 100 GeV2. The two-dimensional shape of the particle-production source was investigated, and a significant difference between the transverse and the longitudinal dimensions of the source is observed. This difference also shows no Q2 dependence. The results demonstrate that Bose-Einstein interference, and hence the size of the particle-production source, is insensitive to the hard subprocess. © 2004 Published by Elsevier B.V