Thyrotropin Serum Values and 3-Year Mortality in Nonagenarians-Reply

Pathophysiology, epidemiology and therapy of agein

Effect and clinical implications of varying the slice thickness and interval on 3-dimensional accuracy of multi-detector CT scanner: the thinner the better?

Near field imaging with open ended waveguides has found increasing interest [1–3]. The basic idea is to scan across samples with a waveguide transducer as a reflection near field probe in order to characterize material properties and image defects that are much smaller than the wavelength. The reflection will form in the waveguide a standing wave where amplitude and phase depend on local intensity and phase of reflection. These effects can be demonstrated with slotted line measurements of the standing wave pattern. For example the investigations in figure 1 show the standing wave patterns for homogenous material and for a hidden hole. Depending on the material properties there is a change in phase and magnitude of the standing wave

Low Serum Free Triiodothyronine Levels Mark Familial Longevity: The Leiden Longevity Study

Background. The hypothalamo-pituitary-thyroid axis has been widely implicated in modulating the aging process. Life extension effects associated with low thyroid hormone levels have been reported in multiple aid mat models. In human populations, an association was observed between low thyroid function and longevity at old age. but the beneficial effects of low thyroid hormone metabolism at middle age remain elusive. Methods. We have compared serum thyroid hormone function parameters in a group of middle-aged offspring of long-living nonagenarian siblings and a control group of their partners, all participants of the Leiden Longevity Study. Results. When compared with their partners, the group of offspring of nonagenarian siblings showed a trend toward higher serum thyrotropin levels (1.65 vs157 mU/L. p = .11) in conjunction with lower free thyroxine levels (15.0 vs 15.2 pmol/L. p = .045) and lower free triiodothyronine levels (4.08 vs 4.14 pmol/L, p = .024). Conclusions. Compared with their partners. the group of offspring of nonagenarian siblings show a lower thyroidal sensitivity to thyrotropin. These findings suggest that the favorable role of low thyroid hormone metabolism on health and longevity in model organism is applicable to humans as wellPathophysiology, epidemiology and therapy of agein