17 research outputs found
Mikrofrakturierung des Kniegelenks: mittelfristige Ergebnisse im internationalen Vergleich
Results of 167 consecutive cases of acetabular fractures using the Kocher-Langenbeck approach: a case series
A prospective randomized comparison of two skin closure techniques in acetabular fracture surgery
Measurement of Lung Cancer Tumor Markers in a Glass Wool Company Workers Exposed to Respirable Synthetic Vitreous Fiber and Dust
Clinical trials and management of osteochondral lesions
Osteochondral lesions are frequent and important causes of pain and disability.
These lesions are induced by traumatic injuries or by diseases that affect both
the cartilage surface and the subchondral bone. Due to the limited cartilage ability to
regenerate and self-repair, these lesions tend to gradually worsen and progress
towards osteoarthritis. The clinical, social, and economic impact of the osteochondral
lesions is impressive and although therapeutic alternatives are under discussion,
a consensus is not yet been achieved. Over the previous decade, new strategies based
on innovative tissue engineering approaches have been developed with promising
results. However, in order those products reach the market and help the actual patient
in an effective manner, there is still a lot of work to be done. The current state of the
implications, clinical aspects, and available treatments for this pathology, as well as
the ongoing preclinical and clinical trials are presented in this chapter.A. da Silva Morais acknowledges ERC-2012-ADG 20120216–321266
(ComplexiTE) for his Postdoc scholarship. Thanks to the project FROnTHERA (NORTE-01-
0145-FEDER-000023), supported by Norte Portugal Regional Operational Programme (NORTE
2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional
Development Fund (ERDF). The financial support from the Portuguese Foundation for Science
and Technology for the M-ERA-NET/0001/2014 “HierarchiTech” project and for the funds
provided under the program Investigador FCT 2012, 2014, and 2015 (IF/00423/2012,
IF/01214/2014, and IF/01285/2015) is also greatly acknowledged.info:eu-repo/semantics/publishedVersio