Rethinking the extrinsic incubation period of malaria parasites

The time it takes for malaria parasites to develop within a mosquito, and become transmissible, is known as the extrinsic incubation period, or EIP. EIP is a key parameter influencing transmission intensity as it combines with mosquito mortality rate and competence to determine the number of mosquitoes that ultimately become infectious. In spite of its epidemiological significance, data on EIP are scant. Current approaches to estimate EIP are largely based on temperature-dependent models developed from data collected on parasite development within a single mosquito species in the 1930s. These models assume that the only factor affecting EIP is mean environmental temperature. Here, we review evidence to suggest that in addition to mean temperature, EIP is likely influenced by genetic diversity of the vector, diversity of the parasite, and variation in a range of biotic and abiotic factors that affect mosquito condition. We further demonstrate that the classic approach of measuring EIP as the time at which mosquitoes first become infectious likely misrepresents EIP for a mosquito population. We argue for a better understanding of EIP to improve models of transmission, refine predictions of the possible impacts of climate change, and determine the potential evolutionary responses of malaria parasites to current and future mosquito control tools

Mental training enhances attentional stability: neural and behavioral evidence.

The capacity to stabilize the content of attention over time varies among individuals, and its impairment is a hallmark of several mental illnesses. Impairments in sustained attention in patients with attention disorders have been associated with increased trial-to-trial variability in reaction time and event-related potential deficits during attention tasks. At present, it is unclear whether the ability to sustain attention and its underlying brain circuitry are transformable through training. Here, we show, with dichotic listening task performance and electroencephalography, that training attention, as cultivated by meditation, can improve the ability to sustain attention. Three months of intensive meditation training reduced variability in attentional processing of target tones, as indicated by both enhanced theta-band phase consistency of oscillatory neural responses over anterior brain areas and reduced reaction time variability. Furthermore, those individuals who showed the greatest increase in neural response consistency showed the largest decrease in behavioral response variability. Notably, we also observed reduced variability in neural processing, in particular in low-frequency bands, regardless of whether the deviant tone was attended or unattended. Focused attention meditation may thus affect both distracter and target processing, perhaps by enhancing entrainment of neuronal oscillations to sensory input rhythms, a mechanism important for controlling the content of attention. These novel findings highlight the mechanisms underlying focused attention meditation and support the notion that mental training can significantly affect attention and brain function

Variability of dense water formation in the Ross Sea

The paper presents results from a model study of the interannual variability of High Salinity Shelf Water (HSSW) properties in the Ross Sea.Salinity, potential temperature and volume of HSSW formed in the western Ross Sea show oscillatory behaviour at periods of 5-6 and 9 years superimposed on long-term fluctuations.While the shorter oscillations are induced by wind variability, variability on the scale of decades appears to be related to air temperature fluctuations.At least part of the strong decrease of HSSW salinities deduced from observations for the period 1963-2000 is shown to be an aliasing artefact due to an undersampling of the periodic signal.While sea ice formation is responsible for the yearly salinity increase that triggers the formation of High Salinity Shelf Water, interannual variability of net freezing rates hardly affects changes in the properties of the resulting water mass.Instead, results from model experiments indicate that the interannual variability of dense water characteristics is predominantly controlled by variations in the shelf inflow through a sub-surface salinity and a deep temperature signal.The origin of the variability of inflow characteristics to the Ross Sea continental shelf can be traced into the Amundsen and Bellingshausen Seas.The temperature anomalies are induced at the continental shelf break in the western Bellingshausen Sea by fluctuations of the meridional transport of Circumpolar Deep Water with the eastern cell of the Ross Gyre.Upwelling in the centre of this gyre carries the signal into the surface layer where it causes anomalies of brine release near the sea ice edge in the Amundsen Sea, which results in a sub-surface salinity anomaly.With the westward flowing coastal current, both the sub-surface salinity and deep temperature signals are advected onto the Ross Sea continental shelf.Convection carries the signal of salinity variability into the deep ocean, where it interacts with Modified Circumpolar Deep Water upwelled onto the continental shelf as the second source water mass of HSSW.Sea ice formation on the Ross Sea continental shelf thus drives the vertical propagation of the signal rather than determining the signal itself

A model of the Antarctic Ice Sheet

Numerical modelling of ice sheets and glaciers has become a useful tool in glaciological research. A model described here deals with the vertical mean ice velocity, is time dependent, computes bedrock adjustment and uses an empirical diagnostic relationship to derive the distribution of ice thickness in ice shelves. The rate of snowfall and ice/snow melt depends on the (prescribed) sea-level temperature, surface slope, elevation and distance to open water. The model is able to reproduce the major. features of the Antarctic Ice Sheet. When it is run to a steady state for present climatic conditions, the main difference with the present ice sheet is that the shallow parts of the Weddell Sea become covered by grounded ice

Novel multipin electrode cap system for dry electroencephalography

Current usage of electroencephalography (EEG) is limited to laboratory environments. Self-application of a multichannel wet EEG caps is practically impossible, since the application of state-of-the-art wet EEG sensors requires trained laboratory staff. We propose a novel EEG cap system with multipin dry electrodes overcoming this problem. We describe the design of a novel 24-pin dry electrode made from polyurethane and coated with Ag/AgCl. A textile cap system holds 97 of these dry electrodes. An EEG study with 20 volunteers compares the 97-channel dry EEG cap with a conventional 128-channel wet EEG cap for resting state EEG, alpha activity, eye blink artifacts and checkerboard pattern reversal visual evoked potentials. All volunteers report a good cap fit and good wearing comfort. Average impedances are below 150 k Omega for 92 out of 97 dry electrodes, enabling recording with standard EEG amplifiers. No significant differences are observed between wet and dry power spectral densities for all EEG bands. No significant differences are observed between the wet and dry global field power time courses of visual evoked potentials. The 2D interpolated topographic maps show significant differences of 3.52 and 0.44 % of the map areas for the N75 and N145 VEP components, respectively. For the P100 component, no significant differences are observed. Dry multipin electrodes integrated in a textile EEG cap overcome the principle limitations of wet electrodes, allow rapid application of EEG multichannel caps by non-trained persons, and thus enable new fields of application for multichannel EEG acquisition.This work was financially supported by the German Federal Ministry of Education and Research (03IPT605A), the German Academic Exchange Service (D/57036536), the Thuringer Aufbaubank and the European Social Fund (2012 FGR 0014), and the European Union (FP7-PEOPLE Marie Curie IAPP project 610950).info:eu-repo/semantics/publishedVersio

Extensive retreat and re-advance of the West Antarctic Ice Sheet during the Holocene

To predict the future contributions of the Antarctic ice sheets to sea-level rise, numerical models use reconstructions of past ice-sheet retreat after the Last Glacial Maximum to tune model parameters1. Reconstructions of the West Antarctic Ice Sheet have assumed that it retreated progressively throughout the Holocene epoch (the past 11,500 years or so)2,3,4. Here we show, however, that over this period the grounding line of the West Antarctic Ice Sheet (which marks the point at which it is no longer in contact with the ground and becomes a floating ice shelf) retreated several hundred kilometres inland of today’s grounding line, before isostatic rebound caused it to re-advance to its present position. Our evidence includes, first, radiocarbon dating of sediment cores recovered from beneath the ice streams of the Ross Sea sector, indicating widespread Holocene marine exposure; and second, ice-penetrating radar observations of englacial structure in the Weddell Sea sector, indicating ice-shelf grounding. We explore the implications of these findings with an ice-sheet model. Modelled re-advance of the grounding line in the Holocene requires ice-shelf grounding caused by isostatic rebound. Our findings overturn the assumption of progressive retreat of the grounding line during the Holocene in West Antarctica, and corroborate previous suggestions of ice-sheet re-advance5. Rebound-driven stabilizing processes were apparently able to halt and reverse climate-initiated ice loss. Whether these processes can reverse present-day ice loss6 on millennial timescales will depend on bedrock topography and mantle viscosity—parameters that are difficult to measure and to incorporate into ice-sheet models