Scenario-Based Design Theorizing:The Case of a Digital Idea Screening Cockpit

As ever more companies encourage employees to innovate, a surplus of ideas has become reality in many organizations – often exceeding the available resources to execute them. Building on insights from a literature review and a 3-year collaboration with a banking software provider, the paper suggests a Digital Idea Screening Cockpit (DISC) to address this challenge. Following a design science research approach, it suggests a prescriptive design theory that provides practitioner-oriented guidance for implementing a DISC. The study shows that, in order to facilitate the assessment, selection, and tracking of ideas for different stakeholders, such a system needs to play a dual role: It needs to structure decision criteria and at the same be flexible to allow for creative expression. Moreover, the paper makes a case for scenario-based design theorizing by developing design knowledge via scenarios

A Barcode Screen for Epigenetic Regulators Reveals a Role for the NuB4/HAT-B Histone Acetyltransferase Complex in Histone Turnover

Dynamic modification of histone proteins plays a key role in regulating gene expression. However, histones themselves can also be dynamic, which potentially affects the stability of histone modifications. To determine the molecular mechanisms of histone turnover, we developed a parallel screening method for epigenetic regulators by analyzing chromatin states on DNA barcodes. Histone turnover was quantified by employing a genetic pulse-chase technique called RITE, which was combined with chromatin immunoprecipitation and high-throughput sequencing. In this screen, the NuB4/HAT-B complex, containing the conserved type B histone acetyltransferase Hat1, was found to promote histone turnover. Unexpectedly, the three members of this complex could be functionally separated from each other as well as from the known interacting factor and histone chaperone Asf1. Thus, systematic and direct interrogation of chromatin structure on DNA barcodes can lead to the discovery of genes and pathways involved in chromatin modification and dynamics

Designing Socio-Technical Systems: A Multi-team Case Study

Technical system design processes are typically based on systems engineering vee models where designers move between functional and physical domains as they develop detailed designs of the overall system and its sub-systems and component parts. The movements between the functional and physical domains are informed by the core activities of any design process: synthesis, description, analysis and simulation, and decision-making. However, delivering socio-technical systems design mindsets, such as those needed to design multi-team systems, requires a new branch of systems science that integrates human behavior into system behavior. Design processes built on such a science would allow system designers to compare alternative solutions in terms of their anticipated performance and consider different options with respect to functions carried out by humans and machines. In this chapter we use a systems design process vee model and apply it to a case study that involves the design of a multi-team customer service system. Both the application of the vee model (i.e., the proposed design process) and the results of its application (i.e., the multi-team customer service system) can be regarded as socio-technical systems and are used to illustrate and elaborate on Clegg’s (Appl Ergon 31(5):463–477, 2000) socio-technical principles for system design. On this basis, we provide a practical framework for designing socio-technical systems and identify requirements for developing future methods and tools to support this process