Clinical therapeutic effect of Fuming tablet for optic nerve function recovery after retinal detachment surgery

AIM: To evaluate the Fuming tablet's clinical therapeutic effect on the recovery of optic nerve function after the retinal detachment surgery.<p>METHODS: Group control study was performed in 60 cases of retinal detachment surgery in our hospital from Jan 2010 to Jan 2013. According to different treatments, these patients were divided into different group. Thirty patients underwent Fuming tablet treatment(observation group),whereas others received mecobalamin injection treatment(control group). All of these patients were followed-up for 6wk. During these processes, we were recording and analyzing their visual acuity, intraocular pressure, ocular fundus condition and retinal nerve fiber layer thickness(RNFLT).<p>RESULTS: The effective rate of visual acuity and ocular fundus in observation group were 90% and 97% respectively, and in control group were 77% and 80% respectively. The difference had statistically significance.(<i>P</i><0.01). Compared with control group, post-treatment a and b wave amplitude of observation group in dark adaptation and light adaptation have significant differences, as well as the difference of a and b wave amplitude in pre-treatment and post-treatment(<i>P</i><0.05). But intraocular pressure had not significantly statistical differences(<i>P</i>>0.05).<p>CONCLUSION: Fuming tablet can improve the absorption of fluid under retina after retinal detachment surgery, the recovery of optic nerve and visual function

Stabilnost i antioksidacijska aktivnost antocijanina iz borovnica

Anthocyanins from highbush blueberry (Vaccinium corymbosum L.) have tremendous potential as natural colorants and functional food with pharmaceutical purposes in food applications. To exploit the potential for food applications, the stability and antioxidant activity of anthocyanins present in blueberries have been studied. The results indicate that anthocyanins from blueberry were stable against the low pH (≤5.0), NaCl (0.125–0.500 mol/L), sucrose (0.584–2.336 mol/L) and preservative (sodium benzoate, 0.035–0.140 mol/L), but were sensitive to alkaline conditions (≥7.0), high temperature (≥80 °C), light (natural light), oxidizing agent (H2O2, 0.5–2.0 %) and reducing agent (Na2SO3, 0.005–0.040 mol/L). At concentrations of 25 and 50 mg/mL, anthocyanins from blueberry could protect ECV-304 cells against oxidative damage induced by H2O2. These results suggest that anthocyanins from blueberry can be regarded as a potential colorant for some acidic (pH≤5.0) food products and could be used as health food to prevent diseases arising from oxidative processes.Antocijanini iz američkih borovnica (Vaccinium corymbosum L.) koriste se u prehrambenoj industriji kao prirodna bojila i za proizvodnju funkcionalne hrane. Stoga je u radu ispitana stabilnost i antioksidacijska aktivnost antocijanina izoliranih iz borovnica. Rezultati pokazuju da su antocijanini bili stabilni pri niskoj pH-vrijednosti (pH≤5) te malim koncentracijama soli (0,125–0,500 mol/L), saharoze (0,584–2,336 mol/L) i konzervansa natrijeva benzoata (0,035–0,140 mol/L), ali osjetljivi u lužnatoj sredini (pH≥7), pri visokoj temperaturi (≥80 °C), na prirodnom izvoru svjetlosti i u prisutnosti oksidansa (H2O2, 0,5–2 %) i reducensa (Na2SO3, 0,005–0,04 mol/L). Antocijanini iz borovnica u koncentracijama od 25 i 50 μg/mL štite ECV-304 stanice od stresa uzrokovanog dodatkom vodikova peroksida. Rezultati pokazuju da se antocijanini iz borovnica mogu upotrijebiti kao bojilo u proizvodnji hrane male pH-vrijednosti (pH≤5) te u proizvodnji zdrave hrane koja sprječava razvoj bolesti uzrokovanih oksidacijskim stresom

Towards Stable Backdoor Purification through Feature Shift Tuning

It has been widely observed that deep neural networks (DNN) are vulnerable to backdoor attacks where attackers could manipulate the model behavior maliciously by tampering with a small set of training samples. Although a line of defense methods is proposed to mitigate this threat, they either require complicated modifications to the training process or heavily rely on the specific model architecture, which makes them hard to deploy into real-world applications. Therefore, in this paper, we instead start with fine-tuning, one of the most common and easy-to-deploy backdoor defenses, through comprehensive evaluations against diverse attack scenarios. Observations made through initial experiments show that in contrast to the promising defensive results on high poisoning rates, vanilla tuning methods completely fail at low poisoning rate scenarios. Our analysis shows that with the low poisoning rate, the entanglement between backdoor and clean features undermines the effect of tuning-based defenses. Therefore, it is necessary to disentangle the backdoor and clean features in order to improve backdoor purification. To address this, we introduce Feature Shift Tuning (FST), a method for tuning-based backdoor purification. Specifically, FST encourages feature shifts by actively deviating the classifier weights from the originally compromised weights. Extensive experiments demonstrate that our FST provides consistently stable performance under different attack settings. Without complex parameter adjustments, FST also achieves much lower tuning costs, only 10 epochs. Our codes are available at https://github.com/AISafety-HKUST/stable_backdoor_purification.Comment: NeurIPS 2023 paper. The first two authors contributed equall

Nonlocal coherence harvesting from quantum vacuum

It is well known that nonlocal coherence reflects nonclassical correlations better than quantum entan-glement. Here, we analyze nonlocal coherence harvesting from the quantum vacuum to particle detectors adiabatically interacting with a quantum scalar field in Minkowski spacetime. We find that the harvesting-achievable separation range of nonlocal coherence is larger than that of quantum entanglement. As the energy gap grows sufficiently large, the detectors harvest less quantum coherence, while the detectors could extract more quantum entanglement from the vacuum state. Compared with the linear configuration and the scalene configuration, the equilateral triangle configuration is the best model to harvest tripartite coherence. Finally, we find a monogamous relationship, which means that tripartite l1-norm of coherence is essentially bipartite types.Comment: 18 pages, 5 figure

A novel multifunctional biomedical material based on polyacrylonitrile:preparation and characterization

Wet spun microfibers have great potential in the design of multifunctional controlled release materials. Curcumin (Cur) and vitamin E acetate (Vit. E Ac) were used as a model drug system to evaluate the potential application of the drug-loaded microfiber system for enhanced delivery. The drugs and polyacrylonitrile (PAN) were blended together and spun to produce the target drug-loaded microfiber using an improved wet-spinning method and then the microfibers were successfully woven into fabrics. Morphological, mechanical properties, thermal behavior, drug release performance characteristics, and cytocompatibility were determined. The drug-loaded microfiber had a lobed “kidney” shape with a height of 50 ~ 100 μm and width of 100 ~ 200 μm. The addition of Cur and Vit. E Ac had a great influence on the surface and cross section structure of the microfiber, leading to a rough surface having microvoids. X-ray diffraction and Fourier transform infrared spectroscopy indicated that the drugs were successfully encapsulated and dispersed evenly in the microfilament fiber. After drug loading, the mechanical performance of the microfilament changed, with the breaking strength improved slightly, but the tensile elongation increased significantly. Thermogravimetric results showed that the drug load had no apparent adverse effect on the thermal properties of the microfibers. However, drug release from the fiber, as determined through in-vitro experiments, is relatively low and this property is maintained over time. Furthermore, in-vitro cytocompatibility testing showed that no cytotoxicty on the L929 cells was found up to 5% and 10% respectively of the theoretical drug loading content (TDLC) of curcumin and vitamin E acetate. This study provides reference data to aid the development of multifunctional textiles and to explore their use in the biomedical material field

Equivalent method for frequency division of complicated impact signal

This article describes a method of frequency division equivalent for complicated impact signal. In the complex impact signal analysis and processing, instantaneous frequency often plays an important role, the instantaneous frequency represents the position of the frequency peak with time, complicated impact signal has their instantaneous frequencies at some point. The method first calculates the power spectrum of the original signal, then the power spectral curve is integrated, the mean square value curve of the whole frequency band is obtained, the frequency amplitude curve can be obtained by square of mean square curve. According to the 1 kHz bandwidth, equal intervals are segmented to the frequency axis, the total root mean square values of each frequency band are calculated respectively, the ratio of each component to the total root mean square value of the whole frequency band is the contribution rate of the frequency band to the whole signal amplitude

Synthetic rabbit-human antibody conjugate as a control in immunoassays for immunoglobulin M specific to hepatitis E virus

<p>Abstract</p> <p>Background</p> <p>In assays for anti-hepatitis E virus (HEV) immunoglobulin M (IgM), large volumes of the patient's sera cannot be easily obtained for use as a positive control. In this study, we investigated an alternative chemical method in which rabbit anti-HEV IgG was conjugated with human IgM and was used as a positive control in the anti-HEV IgM assay. Rabbit anti-HEV IgG was isolated from immune sera by chromatography on protein A-Sepharose and was conjugated with human IgM by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) as a crosslinker.</p> <p>Results</p> <p>The specific anti-HEV IgG antibody titer was 100,000 times that of the negative control, i.e., prebleed rabbit serum. The results of anti-HEV IgM enzyme-linked immunosobent assay showed that the antibody conjugate was similar to anti-HEV IgM antibodies produced in humans. The results of a stability experiment showed that the antibody conjugate was stable for use in external quality assessment or internal quality control trials.</p> <p>Conclusions</p> <p>We concluded that the chemically conjugated rabbit-human antibody could be used instead of the traditional serum control as a positive control in the anti-HEV IgM assay.</p

Chiral odd Chern number lattice supersolidity with tunable unpaired Majorana fermions in a Rydberg-dressed Fermi gas

There is growing interest to search the chiral Majorana fermions that could arise as the quasi-particle edge state of a two-dimensional topological state of matter. Here we propose a new platform, i.e., a two-dimensional chiral odd Chern number lattice supersolid state, for supporting multiple number-tunable chiral Majorana fermions from a single component Rydberg-dressed Fermi gas in an optical lattice. The attractiveness of our idea rests on the fact that by introducing the unveiled competition between two distinct length scales, i.e., lattice period and the distance of resonant Rydberg-dressing, can provide a new way to manipulate the spatial dependence of both the strength and sign of the effective Rydberg-dressed interaction. Such a designed effective interaction turns out, can induce an unveiled odd Chern number lattice supersolid state, which is confirmed by both the mean-field and Monte Carlo calculations. Furthermore, we also find that the spontaneously formed density modulation resulted from the discrete translational symmetry breaking provides a natural way of tuning the system's topology arising from the superfluidity induced by the $U(1)$ symmetry breaking. It thus provide an alternative way for manipulating the chiral Majorana fermions, which would be useful in topological quantum computation.Comment: 6 pages, 5 figures, including Supplementary Materia