The 2010 MW 6.8 Yushu (Qinghai, China) earthquake: constraints provided by InSAR and body wave seismology

By combining observations from satellite radar, body wave seismology and optical imagery, we have determined the fault segmentation and sequence of ruptures for the 2010 Mw 6.8 Yushu (China) earthquake. We have mapped the fault trace using displacements from SAR image matching, interferometric phase and coherence, and 2.5 m SPOT-5 satellite images. Modeling the event as an elastic dislocation with three segments fitted to the fault trace suggests that the southeast and northwest segments are near vertical, with the central segment dipping 70° to the southwest; slip occurs mainly in the upper 10 km, with a maximum slip of 1.5 m at a depth of 4 km on the southeastern segment. The maximum slip in the top 1 km (i.e., near surface) is up to 1.2 m, and inferred locations of significant surface rupture are consistent with displacements from SAR image matching and field observations. The radar interferograms show rupture over a distance of almost 80 km, much larger than initial seismological and field estimates of the length of the fault. Part of this difference can be attributed to slip on the northwestern segment of the fault being due to an Mw 6.1 aftershock two hours after the main event. The remaining difference can be explained by a non-uniform slip distribution with much of the moment release occurring at depths of less than 10 km. The rupture on the central and southeastern segments of the fault in the main shock propagated at a speed of 2.5 km/s southeastward toward the town of Yushu located at the end of this segment, accounting for the considerable building damage. Strain accumulation since the last earthquake on the fault segment beyond Yushu is equivalent to an Mw 6.5 earthquake

Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach

Background: Several methods have been used to induce somatic cells to re-enter the pluripotent state. Viral transduction of reprogramming genes yields higher efficiency but involves random insertions of viral sequences into the human genome. Although induced pluripotent stem (iPS) cells can be obtained with the removable PiggyBac transposon system or an episomal system, both approaches still use DNA constructs so that resulting cell lines need to be thoroughly analyzed to confirm they are free of harmful genetic modification. Thus a method to change cell fate without using DNA will be very useful in regenerative medicine. Methodology/Principal Findings: In this study, we synthesized mRNAs encoding OCT4, SOX2, cMYC, KLF4 and SV40 large T (LT) and electroporated them into human fibroblast cells. Upon transfection, fibroblasts expressed these factors at levels comparable to, or higher than those in human embryonic stem (ES) cells. Ectopically expressed OCT4 localized to the cell nucleus within 4 hours after mRNA introduction. Transfecting fibroblasts with a mixture of mRNAs encoding all five factors significantly increased the expression of endogenous OCT4, NANOG, DNMT3 beta, REX1 and SALL4. When such transfected fibroblasts were also exposed to several small molecules (valproic acid, BIX01294 and 5'-aza-2'-deoxycytidine) and cultured in human embryonic stem cell (ES) medium they formed small aggregates positive for alkaline phosphatase activity and OCT4 protein within 30 days. Conclusion/Significance: Our results demonstrate that mRNA transfection can be a useful approach to precisely control the protein expression level and short-term expression of reprogramming factors is sufficient to activate pluripotency genes in differentiated cells

Background Dependent Lorentz Violation: Natural Solutions to the Theoretical Challenges of the OPERA Experiment

To explain both the OPERA experiment and all the known phenomenological constraints/observations on Lorentz violation, the Background Dependent Lorentz Violation (BDLV) has been proposed. We study the BDLV in a model independent way, and conjecture that there may exist a "Dream Special Relativity Theory", where all the Standard Model (SM) particles can be subluminal due to the background effects. Assuming that the Lorentz violation on the Earth is much larger than those on the interstellar scale, we automatically escape all the astrophysical constraints on Lorentz violation. For the BDLV from the effective field theory, we present a simple model and discuss the possible solutions to the theoretical challenges of the OPERA experiment such as the Bremsstrahlung effects for muon neutrinos and the pion decays. Also, we address the Lorentz violation constraints from the LEP and KamLAMD experiments. For the BDLV from the Type IIB string theory with D3-branes and D7-branes, we point out that the D3-branes are flavour blind, and all the SM particles are the conventional particles as in the traditional SM when they do not interact with the D3-branes. Thus, we not only can naturally avoid all the known phenomenological constraints on Lorentz violation, but also can naturally explain all the theoretical challenges. Interestingly, the energy dependent photon velocities may be tested at the experiments.Comment: RevTex4, 14 pages, minor corrections, references adde

Electroweak Supersymmetry around the Electroweak Scale

Inspired by the phenomenological constraints, LHC supersymmetry and Higgs searches, dark matter search as well as string model building, we propose the electroweak supersymmetry around the electroweak scale: the squarks and/or gluinos are around a few TeV while the sleptons, sneutrinos, bino and winos are within one TeV. The Higgsinos can be either heavy or light. We consider bino as the dominant component of dark matter candidate, and the observed dark matter relic density is achieved via the neutralino-stau coannihilations. Considering the Generalized Minimal Supergravity (GmSUGRA), we show explicitly that the electroweak supersymmetry can be realized, and the gauge coupling unification can be preserved. With two Scenarios, we study the viable parameter spaces that satisfy all the current phenomenological constraints, and we present the concrete benchmark points. Furthermore, we comment on the fine-tuning problem and LHC searches.Comment: RevTex4, 28 pages, 8 figures, 8 tables, version to appear in EPJ

Decoherence and CPT Violation in a Stringy Model of Space-Time Foam

I discuss a model inspired from the string/brane framework, in which our Universe is represented as a three brane, propagating in a bulk space time punctured by D0-brane (D-particle) defects. As the D3-brane world moves in the bulk, the D-particles cross it, and from an effective observer on D3 the situation looks like a ``space-time foam'' with the defects ``flashing'' on and off (``D-particle foam''). The open strings, with their ends attached on the brane, which represent matter in this scenario, can interact with the D-particles on the D3-brane universe in a topologically non-trivial manner, involving splitting and capture of the strings by the D0-brane defects. Such processes are described by logarithmic conformal field theories on the world-sheet. Physically, they result in effective decoherence of the string matter on the D3 brane, and as a result, of CPT Violation, but of a type that implies an ill-defined nature of the effective CPT operator. Due to electric charge conservation, only electrically neutral (string) matter can exhibit such interactions with the D-particle foam. This may have unique, experimentally detectable, consequences for electrically-neutral entangled quantum matter states on the brane world, in particular the modification of the pertinent EPR Correlation of neutral mesons in a meson factory.Comment: 41 pages Latex, five eps figures incorporated. Uses special macro

Critical dynamics of the Potts model: short-time Monte Carlo simulations

We calculate the new dinamic exponent $\theta$ of the 4-state Potts model, using short-time simulations. Our estimates $\theta_{1}=-0.0471(33)$ and $\theta_{2}=$ $-0.0429(11)$ obtained by following the behavior of the magnetization or measuring the evolution of the time correlation function of the magnetization corroborate the conjecture by Okano et. al. In addition, these values agree with previous estimate of the same dynamic exponent for the two-dimensional Ising model with three-spin interactions in one direction, that is known to belong to the same universality class as the 4-state Potts model. The anomalous dimension of initial magnetization $$ is calculated by an alternative way that mixes two different initial conditions. We have also estimated the values of the static exponents $\beta$ and $\nu$. They are in complete agreement with the pertinent results of the literature.Comment: 12 pages, 7 figure

Adhesion model of side contact for an extensible elastic fiber

AbstractFor accurately predicted adhesion laws of fibrillar structures contribute to the rational design of high-performance biomimetic adhesives, an adhesion model is proposed to study the directional adhesion behavior of an extensible elastic fiber that contacts a rigid smooth surface with its side surface under the coupling effect of normal and shear forces, based on the extensible Euler Bernoulli beam theory and the surface energy concept. The deformed configuration of the fiber is obtained analytically, and on the basis of this result, the detachment mode and the normal pull-off force of the fiber for a given shear force are predicted directly. It is also found that, due to the extensibility of the fiber, there exists a maximum normal pull-off force (MNPF) when an optimal shear force is applied. The MNPF will be enhanced by increasing the axial stiffness, and reduced by increasing the bending stiffness. In addition, generating an optimal pre-tension in the adhered part of the fiber will maximize the MNPF. The derived adhesion law is expected to contribute to the optimal design and applications of single-level fibrillar adhesives

Understanding wavelength scaling in 19-cell core hollow-core photonic bandgap fibers

First experimental wavelength scaling in 19-cell core HC-PBGF indicates that the minimum loss waveband occurs at longer wavelengths than previously predicted. Record low loss (2.5dB/km) fibers operating around 2µm and gas-purging experiments are also reported

Protein sequence and structure: Is one more fundamental than the other?

We argue that protein native state structures reside in a novel "phase" of matter which confers on proteins their many amazing characteristics. This phase arises from the common features of all globular proteins and is characterized by a sequence-independent free energy landscape with relatively few low energy minima with funnel-like character. The choice of a sequence that fits well into one of these predetermined structures facilitates rapid and cooperative folding. Our model calculations show that this novel phase facilitates the formation of an efficient route for sequence design starting from random peptides.Comment: 7 pages, 4 figures, to appear in J. Stat. Phy