Suppression of broadband noise radiated by a low-speed fan in a duct

Attenuation of ducted fan noise remains a technical challenge in the low frequency range as traditional duct lining becomes ineffective. This study proposes a reactive method to suppress the sound radiation from an axial-flow fan. The method is particularly effective in the low frequency region and covers a broad band. Its effect is derived from two mechanisms. One is the reduction in the confining effects of duct walls when the duct radius is increased; the other is the acoustic interference between the direct radiation from the fan and reflections by the duct junctions. This interference is always destructive for axial dipoles when the frequency approaches zero. This performance differs from normal passive control methods, which become totally ineffective toward zero frequency. An approximate plane-wave theory explains the essential physics of the method, and its quantitative prediction is found to agree well with a full numerical simulation using a spectral method of Chebyshev collocation. The latter is validated by experiment using an axial-flow fan in a duct of finite length. Broadband noise reduction is achieved while the flow speed is kept unchanged. Practical difficulties of implementation for a fan with high pressure increase are discussed. © 2010 Acoustical Society of America.published_or_final_versio

Effects of inter-particle friction on the critical state behaviour of granular materials: a numerical study

The Conference program's website is located at http://congress.cimne.com/particles2013/frontal/ProgTodo.aspTechnical Session: IS - Instability Mechanisms: From Particles to Structures II (Invited Session)ECCOMAS Thematic Conference SeriesCritical state soil mechanics (CSSM) gives a theoretical framework for soil modelling. This paper investigates the effect of inter-particle friction on the critical state behavior of DEM assemblies with grading representative of a real soil. It is found that the angle of shearing resistance at the critical state increases with increasing inter-particle friction () and in void ratio (e) vs logarithmic mean effective stress (log(p’)) space the critical state locii have higher e values when is higher. An atypical CSL in e-logp’ space that deviates from experimental observations and the classical CSSM behavior was observed when µ = 0.5. Micro-scale analyses show that this can be attributed to the emergence of a higher number of floating particles due to the increasing self-stability of strong force chains with increasing inter-particle friction. This study recommends the use of inter-particle friction lower than 0.5 in DEM simulations of element testing in soil mechanics.published_or_final_versio

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1.

BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1, GSTM1and GSTT1, that code for drug-metabolizing enzymes. This study evaluated whether the polymorphisms in these enzymes were associated with an increased risk of anti-TB drug-induced hepatitis in patients and could potentially be used to identify patients at risk of liver injury. METHODS AND DESIGN: In a cross-sectional study, 2244 tuberculosis patients were assessed two months after the start of treatment. Anti-TB drug-induced liver injury (ATLI) was defined as an ALT, AST or bilirubin value more than twice the upper limit of normal. NAT2, CYP2E1, GSTM1 and GSTT1 genotypes were determined using the PCR/ligase detection reaction assays. RESULTS: 2244 patients were evaluated, there were 89 cases of ATLI, a prevalence of 4% 9 patients (0.4%) had ALT levels more than 5 times the upper limit of normal. The prevalence of ATLI was greater among men than women, and there was a weak association with NAT2*5 genotypes, with ATLI more common among patients with the NAT2*5*CT genotype. The sensitivity of the CT genotype for identifying patients with ATLI was 42% and the positive predictive value 5.9%. CT ATLI was more common among slow acetylators (prevalence ratio 2.0 (95% CI 0.95,4.20) )compared to rapid acetylators. There was no evidence that ATLI was associated with CYP2E1 RsaIc1/c1genotype, CYP2E1 RsaIc1/c2 or c2/c2 genotypes, or GSTM1/GSTT1 null genotypes. CONCLUSIONS: In Xinjiang Uyghur TB patients, liver injury was associated with the genetic variant NAT2*5, however the genetic markers studied are unlikely to be useful for screening patients due to the low sensitivity and low positive predictive values for identifying persons at risk of liver injury

GPS载波相位测量中的信号多路径效应影响研究

Author name used in this publication: 黄丁发Author name used in this publication: 丁晓利, DING Xiao-liAuthor name used in this publication: 钟萍Author name used in this publication: 李成钢Title in Traditional Chinese: GPS載波相位測量中的信號多路徑效應影響研究Journal title in Traditional Chinese: 測繪學報2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Top Quarks as a Window to String Resonances

We study the discovery potential of string resonances decaying to $t\bar{t}$ final state at the LHC. We point out that top quark pair production is a promising and an advantageous channel for studying such resonances, due to their low Standard Model background and unique kinematics. We study the invariant mass distribution and angular dependence of the top pair production cross section via exchanges of string resonances. The mass ratios of these resonances and the unusual angular distribution may help identify their fundamental properties and distinguish them from other new physics. We find that string resonances for a string scale below 4 TeV can be detected via the $t\bar{t}$ channel, either from reconstructing the $t\bar{t}$ semi-leptonic decay or recent techniques in identifying highly boosted tops.Comment: 22 pages, 6 figure

Persistent Hepatitis B Viral Replication in a FVB/N Mouse Model: Impact of Host and Viral Factors

The mechanism underlying the chronicity of hepatitis B virus (HBV) infection has long been an interesting question. However, this mechanism remains unclear largely due to the lack of an animal model that can support persistent HBV replication and allow for the investigation of the relevant immune responses. In this study, we used hydrodynamic injection to introduce HBV replicon DNA into the livers of three different mouse strains: BALB/c, C57BL/6, and FVB/N. Interestingly, we found that an HBV clone persistently replicated in the livers of FVB/N mice for up to 50 weeks but was rapidly cleared from the livers of BALB/c and C57BL/6 mice. Flow cytometric analysis and quantitative reverse transcription PCR analysis of the mouse livers indicated that after DNA injection, FVB/N mice had few intrahepatic activated cytotoxic T lymphocytes (CTLs) and produced low levels of alanine aminotransferase, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and the CXCL9 and CXCL10 chemokines. These findings were in sharp contrast with those observed in BALB/c and C57BL/6 mice, reflecting a strong correlation between the degree of liver inflammation and viral clearance. Mutational analysis further demonstrated that a change of Asn-214 to Ser-214 in the HBV surface antigen rendered the persistent HBV clone clearable in FVB/N mice, which was accompanied by increased levels of activated CTL and upregulated expression of IFN-γ, CXCL9, and CXCL10 in the livers. These results indicate that the heterogeneity of the host factors and viral sequences may influence the immune responses against HBV. An inadequate activation of immune or inflammatory responses can lead to persistent HBV replication in vivo

Self-organization of bacterial biofilms is facilitated by extracellular DNA

Twitching motility-mediated biofilm expansion is a complex, multicellular behavior that enables the active colonization of surfaces by many species of bacteria. In this study we have explored the emergence of intricate network patterns of interconnected trails that form in actively expanding biofilms of Pseudomonas aeruginosa. We have used high-resolution, phase-contrast time-lapse microscopy and developed sophisticated computer vision algorithms to track and analyze individual cell movements during expansion of P. aeruginosa biofilms. We have also used atomic force microscopy to examine the topography of the substrate underneath the expanding biofilm. Our analyses reveal that at the leading edge of the biofilm, highly coherent groups of bacteria migrate across the surface of the semisolid media and in doing so create furrows along which following cells preferentially migrate. This leads to the emergence of a network of trails that guide mass transit toward the leading edges of the biofilm. We have also determined that extracellular DNA (eDNA) facilitates efficient traffic flow throughout the furrow network by maintaining coherent cell alignments, thereby avoiding traffic jams and ensuring an efficient supply of cells to the migrating front. Our analyses reveal that eDNA also coordinates the movements of cells in the leading edge vanguard rafts and is required for the assembly of cells into the "bulldozer" aggregates that forge the interconnecting furrows. Our observations have revealed that large-scale self-organization of cells in actively expanding biofilms of P. aeruginosa occurs through construction of an intricate network of furrows that is facilitated by eDNA

The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice

Dissemination of metastatic cells probably occurs long before diagnosis of the primary tumor. Metastasis during early phases of carcinogenesis in high risk patients is therefore a potential prevention target. The plant polyphenol Curcumin has been proposed for dietary prevention of cancer. We therefore examined its effects on the human breast cancer cell line MDA-MB-231 in vitro and in a mouse metastasis model. Curcumin strongly induces apoptosis in MDA- MB- 231 cells in correlation with reduced activation of the survival pathway NF kappa B, as a consequence of diminished I kappa B and p65 phosphorylation. Curcumin also reduces the expression of major matrix metalloproteinases (MMPs) due to reduced NF kappa B activity and transcriptional downregulation of AP-1. NF kappa B/p65 silencing is sufficient to downregulate c-jun and MMP expression. Reduced NF kappa B/AP-1 activity and MMP expression lead to diminished invasion through a reconstituted basement membrane and to a significantly lower number of lung metastases in immunodeficient mice after intercardiac injection of 231 cells (p=0.0035). 68% of Curcumin treated but only 17% of untreated animals showed no or very few lung metastases, most likely as a consequence of down-regulation of NF kappa B/AP-1 dependent MMP expression and direct apoptotic effects on circulating tumor cells but not on established metastases. Dietary chemoprevention of metastases appears therefore feasible. Copyright (c) 2007 S. Karger AG, Basel

Axion-mediated dark matter and Higgs diphoton signal

We consider axion-mediated dark matter models motivated by Fermi gamma ray line at 130 GeV, where anomaly interactions of an axion-like scalar mediate a singlet Dirac fermion dark matter (DM) to electroweak gauge bosons. In these models, extra vector-like leptons generate anomaly interactions for the axion and can also couple to the SM Higgs boson to modify the Higgs-to-diphoton rate. We can distinguish models by the branching fraction of the DM annihilation into a photon pair, favoring the model with a triplet fermion. From the condition that the lighter charged extra lepton must be heavier than dark matter for no tree-level DM annihilations, we also show that the ratio of Higgs-to-diphoton rate to the SM value is constrained by vacuum stability to 1.4(1.5) for the cutoff scale of 10(1) TeV.Comment: 29 pages, 6 figures, references adde