Networks of nonlinear superconducting transmission line resonators

We investigate a network of coupled superconducting transmission line resonators, each of them made nonlinear with a capacitively shunted Josephson junction coupling to the odd flux modes of the resonator. The resulting eigenmode spectrum shows anticrossings between the plasma mode of the shunted junction and the odd resonator modes. Notably, we find that the combined device can inherit the complete nonlinearity of the junction, allowing for a description as a harmonic oscillator with a Kerr nonlinearity. Using a dc SQUID instead of a single junction, the nonlinearity can be tuned between 10 kHz and 4 MHz while maintaining resonance frequencies of a few gigahertz for realistic device parameters. An array of such nonlinear resonators can be considered a scalable superconducting quantum simulator for a Bose-Hubbard Hamiltonian. The device would be capable of accessing the strongly correlated regime and be particularly well suited for investigating quantum many-body dynamics of interacting particles under the influence of drive and dissipation.Comment: 18 pages, 3 figure

The role of haptic communication in dyadic collaborative object manipulation tasks

Intuitive and efficient physical human-robot collaboration relies on the mutual observability of the human and the robot, i.e. the two entities being able to interpret each other's intentions and actions. This is remedied by a myriad of methods involving human sensing or intention decoding, as well as human-robot turn-taking and sequential task planning. However, the physical interaction establishes a rich channel of communication through forces, torques and haptics in general, which is often overlooked in industrial implementations of human-robot interaction. In this work, we investigate the role of haptics in human collaborative physical tasks, to identify how to integrate physical communication in human-robot teams. We present a task to balance a ball at a target position on a board either bimanually by one participant, or dyadically by two participants, with and without haptic information. The task requires that the two sides coordinate with each other, in real-time, to balance the ball at the target. We found that with training the completion time and number of velocity peaks of the ball decreased, and that participants gradually became consistent in their braking strategy. Moreover we found that the presence of haptic information improved the performance (decreased completion time) and led to an increase in overall cooperative movements. Overall, our results show that humans can better coordinate with one another when haptic feedback is available. These results also highlight the likely importance of haptic communication in human-robot physical interaction, both as a tool to infer human intentions and to make the robot behaviour interpretable to humans

Epidemiology of human adenoviruses: a 20-year retrospective observational study in hospitalized patients in Bern, Switzerland.

Background: Human adenovirus (HAdV) is an important pathogen seen in clinical practice. Long-term studies may help better understand epidemiological trends and changes in circulating genotypes over time. Purpose: Using a large biobank of samples from hospitalized, adenovirus-positive patients over a 20-year period, we aimed to analyze long-term epidemiological trends and genotypic relatedness among circulating HAdV strains. Methods: Based on samples from hospitalized patients confirmed to be HAdV positive in Bern, Switzerland, from 1998 to 2017, and on their associated demographic and clinical data, we identified epidemiological trends and risk factors associated with HAdV infection. HAdV genotyping was performed by PCR amplification and sequencing of the hypervariable hexon gene. The obtained sequences were phylogenetically compared with sequences from international HAdV strains. Results: HAdV was identified in 1302 samples tested. Cases of HAdV infection were reported throughout the years with no clear seasonality. Upper respiratory tract samples, conjunctivitis swabs, and stool had the highest positivity rate (56.2%, 18.7%, and 14.2% of the cases, respectively). HAdV infection was highest among children ≤4 years old. Increased number of HAdV cases were observed in years 2009 (n = 110) and 2010 (n =112). HAdV8 was the predominant genotype among patients older than 20 years, and was mostly associated with ophthalmic infection. Predominant genotypes among children ≤4 years old were HAdV1, HAdV2, and HAdV3, which were mostly associated with respiratory tract infections. Recurring peaks of increased HAdV cases were evidenced every 4 years among children ≤4 years old. Conclusion: Our study gives novel insights on long-term epidemiological trends and phylogenetic relatedness among circulating HAdV strains in Switzerland, country in which little data on HAdV prevalence and diversity was so far available

New Criminal Law Review Symposium on Privilege or Punish: Criminal Justice and the Challenge of Family Ties

This symposium includes three review essays by Professors Doug Berman, Naomi Cahn, and Jack Chin. The review essays are focused on a recent book by Professors Dan Markel, Jennifer M. Collins and Ethan J. Leib entitled \u27Privilege or Punish: Criminal Justice and the Challenge of Family Ties\u27 (Oxford 2009). You can download the entire book for free at http://ssrn.com/abstract=1677503. In addition to the three review essays, the collection includes an essay by the book\u27s authors that serves as a reply to this set of critiques. Collectively, we are grateful to the New Criminal Law Review, which is hosting this collection in an upcoming issue. The essays are titled, respectively: Berman: Digging Deeper into, and Thinking Better about, the Interplay of Families and Criminal Justice Cahn: Protect and Preserve? Chin: Mandatory, Contingent, and Discretionary Policy Arguments Collins, Leib & Markel: (When) Should Family Status Matter in the Criminal Justice System

New Criminal Law Review Symposium on Privilege or Punish: Criminal Justice and the Challenge of Family Ties

This symposium includes three review essays by Professors Doug Berman, Naomi Cahn, and Jack Chin. The review essays are focused on a recent book by Professors Dan Markel, Jennifer M. Collins and Ethan J. Leib entitled \u27Privilege or Punish: Criminal Justice and the Challenge of Family Ties\u27 (Oxford 2009). You can download the entire book for free at http://ssrn.com/abstract=1677503. In addition to the three review essays, the collection includes an essay by the book\u27s authors that serves as a reply to this set of critiques. Collectively, we are grateful to the New Criminal Law Review, which is hosting this collection in an upcoming issue. The essays are titled, respectively: Berman: Digging Deeper into, and Thinking Better about, the Interplay of Families and Criminal Justice Cahn: Protect and Preserve? Chin: Mandatory, Contingent, and Discretionary Policy Arguments Collins, Leib & Markel: (When) Should Family Status Matter in the Criminal Justice System

Adjuvant TACE inhibitor treatment improves the outcome of TLR2(-/- )mice with experimental pneumococcal meningitis

BACKGROUND: Streptococcus (S.) pneumoniae meningitis has a high lethality despite antibiotic treatment. Inflammation is a major pathogenetic factor, which is unresponsive to antibiotics. Therefore adjunctive therapies with antiinflammatory compounds have been developed. TNF484 is a TNF-alpha converting enzyme (TACE) inhibitor and has been found efficacious in experimental meningitis. Toll-like receptor 2 (TLR2) contributes to host response in pneumococcal meningitis by enhancing bacterial clearing and downmodulating inflammation. In this study, TNF484 was applied in mice, which lacked TLR2 and exhibited a strong meningeal inflammation. METHODS: 10(3 )CFU S. pneumoniae serotype 3 was inoculated subarachnoidally into C57BL/6 wild type (wt) mice or TLR2(-/-), CD14(-/- )and CD14(-/-)/TLR2(-/- )mice. Severity of disease and survival was followed over 9 days. Response to antibiotics (80 mg/kg ceftriaxone i.p. for 5 days) and/or TACE inhibitor treatment (1 mg/kg s.c. twice daily for 4 days) was evaluated. Animals were sacrificed after 12, 24, and 48 h for analysis of bacterial load in cerebrospinal fluid (CSF) and brain and for TNF and leukocyte measurements in CSF. RESULTS: TLR2(-/- )mice were significantly sicker than the other mouse strains 24 h after infection. All knockout mice showed higher disease severity after 48 h and died earlier than wt mice. TNF release into CSF was significantly more elevated in TLR2(-/- )than in the other strains after 24 h. Brain bacterial numbers were significantly higher in all knockout than wt mice after 24 h. Modulation of outcome by antibiotic and TACE inhibitor treatment was evaluated. With antibiotic therapy all wt, CD14(-/- )and TLR2(-/-)/CD14(-/- )mice, but only 79% of TLR2(-/- )mice, were rescued. TACE inhibitor treatment alone did not rescue, but prolonged survival in wt mice, and in TLR2(-/- )and CD14(-/- )mice to the values observed in untreated wt mice. By combined antibiotic and TACE inhibitor treatment 95% of TLR2(-/- )mice were rescued. CONCLUSION: During pneumococcal meningitis strong inflammation in TLR2-deficiency was associated with incomplete responsiveness to antibiotics and complete response to combined antibiotic and TACE inhibitor treatment. TACE inhibitor treatment offers a promising adjuvant therapeutic strategy in pneumococcal meningitis

Arrays of waveguide-coupled optical cavities that interact strongly with atoms

We describe a realistic scheme for coupling atoms or other quantum emitters with an array of coupled optical cavities. We consider open Fabry-Perot microcavities coupled to the emitters. Our central innovation is to connect the microcavities to waveguide resonators, which are in turn evanescently coupled to each other on a photonic chip to form a coupled cavity chain. In this paper, we describe the components, their technical limitations and the factors that need to be determined experimentally. This provides the basis for a detailed theoretical analysis of two possible experiments to realize quantum squeezing and controlled quantum dynamics. We close with an outline of more advanced applications.Comment: 30 pages, 8 figures. Submitted to New Journal of Physic

Mesoscopic mean-field theory for spin-boson chains in quantum optical systems

We present a theoretical description of a system of many spins strongly coupled to a bosonic chain. We rely on the use of a spin-wave theory describing the Gaussian fluctuations around the mean-field solution, and focus on spin-boson chains arising as a generalization of the Dicke Hamiltonian. Our model is motivated by experimental setups such as trapped ions, or atoms/qubits coupled to cavity arrays. This situation corresponds to the cooperative (E⊗β) Jahn-Teller distortion studied in solid-state physics. However, the ability to tune the parameters of the model in quantum optical setups opens up a variety of novel intriguing situations. The main focus of this paper is to review the spin-wave theoretical description of this problem as well as to test the validity of mean-field theory. Our main result is that deviations from mean-field effects are determined by the interplay between magnetic order and mesoscopic cooperativity effects, being the latter strongly size-dependent

Genome Sequences of Rare Human Enterovirus Genotypes Recovered from Clinical Respiratory Samples in Bern, Switzerland.

We report on genomic sequences of human enteroviruses (EVs) that were identified in respiratory samples in Bern, Switzerland, in 2018 and 2019. Besides providing sequences for coxsackievirus A2, echovirus 11, and echovirus 30, we determined the sequences of rare EV-D68 and EV-C105 genotypes circulating in Switzerland