Some Characteristics of Polar Bears Killed during Conflicts with Humans in the Northwest Territories, 1976-86

We examined 265 cases where polar bears were killed in the Northwest Territories as a result of bear-human encounters between 1 July 1976 and 30 June 1986. Age and sex of the bears, time of year and general circumstances of the cases were characterized. Subadult animals constituted 53% of the aged sample, and males accounted for 70% of the sexed bears. Subadult males represented 40% of known age and sex bears. Problem kills occurred throughout the year but were most frequent in the ice-free season (August-November). In 222 cases where circumstances surrounding the death were known, 63% were associated with Inuit on the land, 18% with settlements, 15% were industrial sites and 4% with research activities. Most problem kills (87%) were not included in the quota harvest. This mortality in excess of the quota may adversely affect some populations. Therefore, wherever possible we encourage the inclusion of problem bears on community quotas.Key words: polar bear (Ursus maritimus), problem bears, bear-human encounters, Arctic, Northwest TerritoriesMots clés: ours polaire (Ursus maririmus), ours-problèmes, rencontres entre l’homme et l’ours, Arctique, Territoires du Nord-Oues

Power and the translator: Joseph Conrad in Chinese translations during the Republican era (1912-1937)

When he died in 1924, Joseph Conrad, who was named a ‘racist’ by Chinua Achebe (1977) and defended by others as taking an anti-imperialist stance (Brantlinger 1996), was a total stranger to the Chinese readers, whose country was made a semi-colony in the late nineteenth century. In the 1930s, however, four of his works were translated and published within four years, all commissioned by the Committee on Editing and Translation funded by the China Foundation for the Promotion of Education and Culture. The thesis investigates the Chinese translations of Conrad’s works published during the Republican Era in 1912-1937, exploring the power relations between the translators as agents and the social structure in which they operated. The thesis is divided into six chapters. After the introduction, I describe, in Chapter 2, the translators’ practice in terms of their narrating positions on the textual and paratextual levels as reflected in the translations of the sea stories borrowing analytical models on narrative discourse devised by Gérard Genette and Roger Fowler. I proceed in Chapter 3 with an account of the commissioner, tracking down the organization of the China Foundation and the Committee on Editing and Translation which initiated the project of translating World Classics (including Conrad’s works) in the 1930s. In Chapter 4, I reassess the notion of ‘faithfulness’, a key concept in the discourse of translation in theory and criticism at the time. Using Pierre Bourdieu’s theory of practice as the theoretical framework, I argue that the practice of the translators, who created the image of Conrad through their translations, can be explained with reference to their relations with other agents (commissioners, theorists, critics, etc.) occupying different positions within the intellectual field, and the habitus which mediated their position and the social structure they were engaged in Chapter 5, followed by the conclusion

Cystic fibrosis co-existing with trisomy 21

AbstractPrevious reports of children with co-existence of cystic fibrosis and full trisomy 21 suggest a very poor prognosis, with the majority of cases dying in infancy and the oldest reported survivor being 6years of age. We report the case of a young man with genetically confirmed trisomy 21 and homozygous for the F508del cystic fibrosis mutation. Despite the diagnosis of cystic fibrosis being delayed until the age of 2years he has transitioned to adult services and is now 25years of age. Currently he has poor lung function and a continuous ambulatory oxygen requirement

Comparison of gene expression profile between human chondrons and chondrocytes: a cDNA microarray study

SummaryObjectiveThe chondron is a basic unit of articular cartilage that includes the chondrocyte and its pericellular matrix (PCM). This current study was designed to investigate the effects of the chondron PCM on the gene expression profile of chondrocytes.DesignChondrons and chondrocytes were enzymatically isolated from human articular cartilage, and maintained in pellet culture. Pellets of chondrons or chondrocytes were collected at days 1, 3 and 5 for cDNA microarray analysis.ResultsIn comparison with chondrocytes alone, chondrons had 258 genes, in a broad range of functional categories, either up- or downregulated at the three time points tested. At day 1, 26 genes were significantly upregulated in chondrons and four downregulated in comparison to chondrocytes. At day 3, the number of upregulated chondron genes was 97 and the number downregulated was 43. By day 5, there were more downregulated genes (56) than upregulated genes (32) in chondrons. Upregulation of a group of heat shock proteins (HSPA1A, HSPA2 and HSPA8) in chondrons was validated by real time reverse transcription polymerase chain reaction (RT-PCR). Genes related to chondrocyte hypertrophy and dedifferentiation such as SSP1 and DCN were downregulated in chondrons as compared to the expression in chondrocytes.ConclusionThe presence of the PCM in chondrons has a profound influence on chondrocyte gene expression. Upregulation of the heat shock protein 70 may contribute to the robustness and active matrix production of chondrons. The intact PCM may further stabilize the phenotype of chondrocytes within chondrons

Comparison of gene expression profile between human chondrons and chondrocytes: a cDNA microarray study

OBJECTIVE: The chondron is a basic unit of articular cartilage that includes the chondrocyte and its pericellular matrix (PCM). This current study was designed to investigate the effects of the chondron PCM on the gene expression profile of chondrocytes. DESIGN: Chondrons and chondrocytes were enzymatically isolated from human articular cartilage, and maintained in pellet culture. Pellets of chondrons or chondrocytes were collected at days 1, 3 and 5 for cDNA microarray analysis. RESULTS: In comparison with chondrocytes alone, chondrons had 258 genes, in a broad range of functional categories, either up- or downregulated at the three time points tested. At day 1, 26 genes were significantly upregulated in chondrons and four downregulated in comparison to chondrocytes. At day 3, the number of upregulated chondron genes was 97 and the number downregulated was 43. By day 5, there were more downregulated genes (56) than upregulated genes (32) in chondrons. Upregulation of a group of heat shock proteins (HSPA1A, HSPA2 and HSPA8) in chondrons was validated by real time reverse transcription polymerase chain reaction (RT-PCR). Genes related to chondrocyte hypertrophy and dedifferentiation such as SSP1 and DCN were downregulated in chondrons as compared to the expression in chondrocytes. CONCLUSION: The presence of the PCM in chondrons has a profound influence on chondrocyte gene expression. Upregulation of the heat shock protein 70 may contribute to the robustness and active matrix production of chondrons. The intact PCM may further stabilize the phenotype of chondrocytes within chondrons

Two-Dimensional Picture Grammar Models.

A new theoretical model of grammatical picture generation called extended 2D context-free picture grammar (E2DCFPG) generating rectangular picture arrays of symbols is introduced. This model which allows variables in the grammar and uses the squeezing mechanism of forming the picture language over terminal symbols, is an extension of the pure 2D context-free picture grammar (P2DCFPG) [13]. The extended picture grammar model E2DCFPG is shown to have more picture generative power than the P2DCFPG and certain other existing 2D models. Certain closure and other properties of this new model are also examine