84 research outputs found
Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]
- Author
- A Aguzzi
- A Brachmann
- A Kishimoto
- A Romanelli
- A Santoso
- AF Hill
- AH DePace
- AJ Ball
- AV Kajava
- B Caughey
- B Chen
- BH Toyama
- BK Patel
- BK Patel
- C Resende
- C Vital
- CY King
- CY King
- DA Kocisko
- DJ Selkoe
- DM Fowler
- DM Fowler
- DM Walsh
- E Cohen
- ED Ross
- F Shewmaker
- G Legname
- GM Shankar
- HL True
- HL True
- HY Chang
- HY Lian
- IL Derkatch
- IL Derkatch
- IL Derkatch
- IV Baskakov
- J Collinge
- J Collinge
- J Collinge
- J Krzewska
- J Nemecek
- J Safar
- J Shorter
- J Shorter
- J Shorter
- J Tyedmers
- JJ Liu
- JP Cleary
- JR Glover
- JR Glover
- K Iwata
- K Si
- KA Dill
- KV Volkov
- L Li
- LC Serpell
- LZ Osherovich
- M Bruce
- M Scott
- M Tanaka
- M Tanaka
- M Tanaka
- MD Michelitsch
- MD Ter-Avanesyan
- MD Yoder
- ME Bruce
- MF Tuite
- ML Maddelein
- MM Patino
- MM Patino
- MR Chapman
- MR Sawaya
- N Sondheimer
- NR Deleault
- OS Makin
- P Chien
- P Chien
- P Chien
- P Collin
- P Silar
- PC van der Wel
- Peter M Tessier
- PM Tessier
- R Diaz-Avalos
- R Kayed
- R Krishnan
- R Nelson
- R Nelson
- R Wetzel
- RA Bessen
- RB Wickner
- RB Wickner
- RB Wickner
- RB Wickner
- S Alberti
- S Catharino
- S Lesné
- S Lindquist
- S Mukhopadhyay
- S Shivaprasad
- S Supattapone
- SB Prusiner
- SB Prusiner
- SB Prusiner
- SL Crick
- SM Uptain
- SN Parham
- SR Collins
- SS Eaglestone
- Susan Lindquist
- SV Paushkin
- SV Paushkin
- T Nakayashiki
- T Scheibel
- T Scheibel
- TR Serio
- TW Muir
- V Coustou
- V Coustou
- VV Kushnirov
- WA Voter
- YO Chernoff
- YO Chernoff
- Z Du
- Z Tallóczy
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2009
- Field of study
Prions are proteins that can access multiple conformations, at least one of which is beta-sheet rich, infectious and self-perpetuating in nature. These infectious proteins show several remarkable biological activities, including the ability to form multiple infectious prion conformations, also known as strains or variants, encoding unique biological phenotypes, and to establish and overcome prion species (transmission) barriers. In this Perspective, we highlight recent studies of the yeast prion [PSI+], using various biochemical and structural methods, that have begun to illuminate the molecular mechanisms by which self-perpetuating prions encipher such biological activities. We also discuss several aspects of prion conformational change and structure that remain either unknown or controversial, and we propose approaches to accelerate the understanding of these enigmatic, infectious conformers
Conference Highlights of the 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses, 26–30 June 2013, Montreal, Canada
- Author
- A Achachi
- A Babaian
- A Bazarbachi
- A Bazarbachi
- A Choudhary
- A de Brogniez
- A Gessain
- A Gessain
- A Hodson
- A Lezin
- A Lezin
- A Marcais
- A Marçais
- A Melamed
- A Melamed
- A Narayanan
- A Pimentel
- A Rowan AG McCallin
- A Sze
- A Utsunomiya
- AA Phillips
- AGT Adonis
- AL Mason
- ALG Coler-Reilly
- Ali Bazarbachi
- AR Panfil
- AS Souza
- B Albrecht
- B Barbeau
- B Choudhury
- B Usadi
- Benoit Barbeau
- BM de Lourdes
- C Alvarez
- C Filippone
- C Martínez
- C Morris
- C Pise-Masison
- C Vernin
- CCC de Campos
- CS Barrios
- D Fujikawa
- D Kodama
- D Rauch
- D Tanajura
- D Xiang
- DA Rauch
- DB Reiss
- DC Cilião-Alves
- DF Roucoux
- DJ Laydon
- DY Jin
- E Betsem
- E Ikebe
- E Larocque
- E Matsuura
- Edgar Carvalho
- Edward L Murphy
- F Bahia
- F Huang
- F Martin
- F Martin
- Fabiola Martin
- G Belrose
- G Campuzano-Zuluaga
- G de The
- G Kchour
- G Kchour
- G Ma
- G Pataccini
- GS Brunetto
- H Cláudia LF
- H El Hajj
- H Gazon
- H Kagdi
- H Kagdi
- H Kwon
- H Niederer
- H Zheng
- HE Hajj
- HJ Alter
- I Choi
- I Guendel
- J Van Weyenbergh
- J Villaudy
- J Yamazaki
- JM Fox
- John Hiscott
- JT Bartoe
- JT Kimata
- K Delviks-Frankenberry
- K Durkin
- K Tezuka
- K Tezuka
- K Tsukasaki
- K Twigger
- K Verdonck
- K Yamamoto
- K Yonekura
- Kathryn Jones
- KN Meekings
- KS Jones
- L Cook
- L Cunha
- L Einsiedel
- L Gao
- L Labanca
- L Xu
- L Xu
- LC Romanelli
- LCF Romanelli
- Lee Ratner
- LR Silverman
- M Amano
- M Goicochea
- M Huleihel
- M Menna-Barreto
- M Miura
- M Puccioni-Sohler
- M Saito
- M Thenoz
- M Yamagishi
- M Yamagishi
- Masao Matsuoka
- MC Mann
- MD Dodon
- MF de Castro-Amarante
- MF Kearney
- MR Anderson
- MRP Gascón
- MT Pinto
- N Boa- Sorte
- N Polakowski
- NA Gillet
- ND Collins
- ND Wolfe
- O Cassar
- PC Gonçalves
- PV Afonso
- PY Barez
- R Khouri
- R Kurth
- R Mahieux
- R Massoud
- R Massoud
- R Okajima
- R Pornkuna
- R Rua
- R Van Duyne
- RA Weiss
- RHC Bastos
- S Ahmed
- S Alais
- S Calattini
- S Calattini
- S Calattini
- S Gross
- S Honarbakhsh
- S Kinpara
- S Nozuma
- S Olindo
- S Pène
- S Rahman
- S Rahman
- S Santos
- S Souquière
- S Takemoto
- SA Chevalier
- SA Chevalier
- SE Croxford
- SM Menezes
- SM Rodríguez
- SR Gadelha
- SR Gadelha
- SS Bassi
- T Matsuzaki
- T Ohsugi
- T Ohsugi
- T Oka
- T Sato
- T Ueno
- T Uto
- TA dos Santos
- Toshiki Watanabe
- V Mocquet
- VN Olavarria
- VW Valeri
- W Switzer
- W Wang
- William M Switzer
- WJ Grossman
- WM Switzer
- WM Switzer
- WM Switzer
- WM Switzer
- WM Switzer
- WM Switzer
- Y Aida
- Y Aida
- Y Enose-Akahata
- Y Enose-Akahata
- Y Maeda
- Y Satou
- Y Suehiro
- Y Tanaka
- Y Yamano
- Y Yamano
- YB Chang
- É Larocque
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
HUMAN T-LYMPHOTROPIC VIRUS 1 (HTLV-1) AND HUMAN T-LYMPHOTROPIC VIRUS 2 (HTLV-2): GEOGRAPHICAL RESEARCH TRENDS AND COLLABORATION NETWORKS (1989-2012)
- Author
- Abbasi A
- Almeida EA
- Araujo A
- Biglione M
- Biswas HH
- Blas MM
- Borgatti SP
- Calattini S
- Carmen de MENDOZA
- Casoli C
- Casseb J
- Charles HUAMANÍ
- Chen DM
- de Thé G
- Einsiedel L
- Facchinetti LD
- Falagas ME
- Gastaldello R
- Gessain A
- González-Alcaide G
- Gregorio GONZÁLEZ-ALCAIDE
- Hlela C
- Jones CW
- José Manuel RAMOS
- Keiser J
- Lehky T
- Lin HW
- Luchs A
- López-Illescas C
- Mahieux R
- Morel CM
- Ngudi DD
- Poiesz B
- Proietti F
- Ramos JM
- Ramos JM
- Rollin RL
- Romanelli LC
- Rosas SR
- Roucoux D
- Safahieh H
- Schoonbaert D
- Sevinc A
- Treviño A
- Treviño A
- Verdonck K
- Verdonck K
- Vicent SORIANO
- Vioque J
- Watanabe T
- Yan E
- Zheng HC
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2016
- Field of study
Search for continuous gravitational waves from 20 accreting millisecond x-ray pulsars in O3 LIGO data
- Author
- Abbott R
- Abbott T
- Acernese F
- Ackley K
- Adams C
- Adhikari N
- Adhikari R
- Adya V
- Affeldt C
- Agarwal D
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar O
- Aiello L
- Ain A
- Akutsu T
- Albanesi S
- Albayati A
- Allocca A
- Altamirano D
- Altin P
- Amato A
- Anand C
- Anand S
- Ananyeva A
- Anderson S
- Anderson W
- Ando M
- Andrade T
- Andres N
- Andrić T
- Angelova S
- Ansoldi S
- Antelis J
- Antier S
- Appert S
- Arai K
- Arai Y
- Araki S
- Araya A
- Araya M
- Areeda J
- Arellano FP
- Aritomi N
- Arnaud N
- Aronson S
- Arun K
- Arène M
- Asada H
- Asali Y
- Ashton G
- Aso Y
- Assiduo M
- Aston S
- Astone P
- Aubin F
- Austin C
- Babak S
- Badaracco F
- Bader M
- Badger C
- Bae S
- Bae Y
- Baer A
- Bagnasco S
- Bai Y
- Baiotti L
- Baird J
- Bajpai R
- Ball M
- Ballardin G
- Ballmer S
- Balsamo A
- Baltus G
- Banagiri S
- Bankar D
- Barayoga J
- Barbieri C
- Barish B
- Barker D
- Barneo P
- Barone F
- Barr B
- Barsotti L
- Barsuglia M
- Barta D
- Bartlett J
- Barton M
- Bartos I
- Bassiri R
- Basti A
- Bawaj M
- Bayley J
- Baylor A
- Bazzan M
- Bedakihale V
- Bejger M
- Belahcene I
- Benedetto V
- Beniwal D
- Bennett T
- Bentley J
- BenYaala M
- Bergamin F
- Berger B
- Bernuzzi S
- Bersanetti D
- Bertolini A
- Betzwieser J
- Beveridge D
- Bhandare R
- Bhardwaj U
- Bhattacharjee D
- Bhaumik S
- Bilenko I
- Billingsley G
- Bini S
- Birney R
- Birnholtz O
- Biscans S
- Bischi M
- Biscoveanu S
- Bisht A
- Biswas B
- Bitossi M
- Bizouard M
- Blackburn J
- Blair C
- Blair D
- Blair R
- Bobba F
- Bode N
- Boer M
- Bogaert G
- Boldrini M
- Bonavena L
- Bondu F
- Bonilla E
- Bonnand R
- Booker P
- Boom B
- Bork R
- Boschi V
- Bose N
- Bose S
- Bossilkov V
- Boudart V
- Bouffanais Y
- Bozzi A
- Bradaschia C
- Brady P
- Bramley A
- Branch A
- Branchesi M
- Brau J
- Breschi M
- Briant T
- Briggs J
- Brillet A
- Brinkmann M
- Brockill P
- Brooks A
- Brooks J
- Brown D
- Brunett S
- Bruno G
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- Bryant J
- Bulik T
- Bult P
- Bulten H
- Buonanno A
- Buscicchio R
- Buskulic D
- Bustillo JC
- Buy C
- Byer R
- Bécsy B
- Cadonati L
- Cagnoli G
- Cahillane C
- Callaghan J
- Callister T
- Calloni E
- Cameron J
- Camp J
- Canepa M
- Canevarolo S
- Cannavacciuolo M
- Cannon K
- Canton TD
- Cao H
- Cao Z
- Capocasa E
- Capote E
- Carapella G
- Carbognani F
- Carlin J
- Carney M
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- Carrillo G
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- Carver T
- Casentini C
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- Chaibi W
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- Chan C
- Chan K
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- Chandra K
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- Chao S
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- Chase E
- Chassande-Mottin E
- Chatterjee C
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- Di Giorgio C
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for gravitational waves from Scorpius X-1 with a hidden Markov model in O3 LIGO data
- Author
- Abbott R
- Abe H
- Acernese F
- Ackley K
- Adhikari N
- Adhikari R
- Adkins V
- Adya V
- Affeldt C
- Agarwal D
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar O
- Aiello L
- Ain A
- Ajith P
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- Amato A
- Anand C
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- Appavuravther E
- Appert S
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- Arellano F
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- Fidecaro F
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for gravitational waves associated with gamma-ray bursts detected by Fermi and Swift during the LIGO–Virgo run O3b
- Author
- Abbott R
- Abbott TD
- Acernese F
- Ackley K
- Adams C
- Adhikari N
- Adhikari RX
- Adya VB
- Affeldt C
- Agarwal D
- Agathos M
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- Arellano FEP
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- Arun KG
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- Barton MA
- Bartos I
- Bassiri R
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- Sintes AM
- Sipala V
- Skliris V
- Slagmolen BJJ
- Slaven-Blair TJ
- Smetana J
- Smith JR
- Smith RJE
- Soldateschi J
- Somala SN
- Somiya K
- Son EJ
- Soni K
- Soni S
- Sordini V
- Sorrentino F
- Sorrentino N
- Sotani H
- Soulard R
- Souradeep T
- Sowell E
- Spagnuolo V
- Spencer AP
- Spera M
- Srinivasan R
- Srivastava AK
- Srivastava V
- Staats K
- Stachie C
- Steer DA
- Steinlechner J
- Steinlechner S
- Stops DJ
- Stover M
- Strain KA
- Strang LC
- Stratta G
- Strunk A
- Sturani R
- Stuver AL
- Subrahmanya SC
- Sudhagar S
- Sudhir V
- Sugimoto R
- Suh HG
- Summerscales TZ
- Sun H
- Sun L
- Sunil S
- Sur A
- Suresh J
- Sutton PJ
- Suzuki T
- Suzuki T
- Swinkels BL
- Szczepanczyk MJ
- Szewczyk P
- Tacca M
- Tagoshi H
- Tait SC
- Takahashi H
- Takahashi R
- Takamori A
- Takano S
- Takeda H
- Takeda M
- Talbot C
- Talbot CJ
- Tanaka H
- Tanaka K
- Tanaka K
- Tanaka T
- Tanaka T
- Tanasijczuk AJ
- Tanioka S
- Tanner DB
- Tao D
- Tao L
- Taranto C
- Tasson JD
- Telada S
- Tenorio R
- Terhune JE
- Terkowski L
- Thirugnanasambandam MP
- Thomas M
- Thomas P
- Thompson EE
- Thompson JE
- Thondapu SR
- Thorne KA
- Thrane E
- Tiwari S
- Tiwari S
- Tiwari V
- Toivonen AM
- Toland K
- Tolley AE
- Tomaru T
- Tomigami Y
- Tomura T
- Tonelli M
- Torres-Forne A
- Torrie CI
- Toyra D
- Trapananti A
- Travasso F
- Traylor G
- Trevor M
- Tringali MC
- Tripathee A
- Troiano L
- Trovato A
- Trozzo L
- Trudeau RJ
- Tsai D
- Tsai DS
- Tsang KW
- Tsang T
- Tsao J-S
- Tse M
- Tso R
- Tsubono K
- Tsuchida S
- Tsukada L
- Tsuna D
- Tsutsui T
- Tsuzuki T
- Turbang K
- Turconi M
- Tuyenbayev D
- Ubhi AS
- Uchikata N
- Uchiyama T
- Udall RP
- Ueda A
- Uehara T
- Ueno K
- Ueshima G
- Unnikrishnan CS
- Uraguchi F
- Urban AL
- Ushiba T
- Utina A
- Vahlbruch H
- Vajente G
- Vajpeyi A
- Valdes G
- Valentini M
- Valsan V
- van Bakel N
- van Beuzekom M
- van den Brand JFJ
- Van Den Broeck C
- van der Schaaf L
- van Heijningen JV
- van Putten MHPM
- van Remortel N
- Vander-Hyde DC
- Vanosky J
- Vardaro M
- Vargas AF
- Varma V
- Vasuth M
- Vecchio A
- Vedovato G
- Veitch J
- Veitch PJ
- Venneberg J
- Venugopalan G
- Verkindt D
- Verma P
- Verma Y
- Veske D
- Vetrano F
- Vicere A
- Vidyant S
- Viets AD
- Vijaykumar A
- Villa-Ortega V
- Vinet J-Y
- Virtuoso A
- Vitale S
- Vivanco FH
- Vo T
- Vocca H
- von Reis ERG
- von Wrangel JSA
- Vorvick C
- Vyatchanin SP
- Wade LE
- Wade M
- Wagner KJ
- Walet RC
- Walker M
- Wallace GS
- Wallace L
- Walsh S
- Wang J
- Wang JZ
- Wang WH
- Ward RL
- Warner J
- Was M
- Washimi T
- Washington NY
- Watchi J
- Weaver B
- Webster SA
- Weinert M
- Weinstein AJ
- Weiss R
- Weller CM
- Wellmann F
- Wen L
- Wessels P
- Wette K
- Whelan JT
- White DD
- Whiting BF
- Whittle C
- Wilken D
- Williams D
- Williams MJ
- Williamson AR
- Willis JL
- Willke B
- Wilson DJ
- Winkler W
- Wipf CC
- Wlodarczyk T
- Woan G
- Woehler J
- Wofford JK
- Wong ICF
- Wu C
- Wu DS
- Wu H
- Wu S
- Wysocki DM
- Xiao L
- Xu W-R
- Yamada T
- Yamamoto H
- Yamamoto K
- Yamamoto K
- Yamamoto T
- Yamashita K
- Yamazaki R
- Yang FW
- Yang L
- Yang Y
- Yang Y
- Yang Z
- Yap MJ
- Yeeles DW
- Yelikar AB
- Ying M
- Yokogawa K
- Yokoyama J
- Yokozawa T
- Yoo J
- Yoshioka T
- Yu H
- Yu H
- Yuzurihara H
- Zadrozny A
- Zanolin M
- Zeidler S
- Zelenova T
- Zendri J-P
- Zevin M
- Zhan M
- Zhang H
- Zhang J
- Zhang L
- Zhang T
- Zhang Y
- Zhao C
- Zhao G
- Zhao Y
- Zhao Y
- Zheng Y
- Zhou R
- Zhou Z
- Zhu XJ
- Zhu Z-H
- Zimmerman AB
- Zucker ME
- Zweizig J
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2022
- Field of study
We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC–2020 March 27 17:00 UTC). We conduct two independent searches: a generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate
Clinical evaluation of a wound measurement and documentation system
- Publication venue
- Publication date
- 01/01/2008
- Field of study
Abstract: Wound measurement is essential in assessing the progress of
wound healing. The most commonly used tools include wound tracings,
width and length measurements, and digital photography. These
methods have been useful in clinical practice but have some limitations,
such as lack of accuracy, difficulty of use, and often entail
wound contact. More advanced equipment tends to be bulky, heavy,
and expensive. The following reviews the authors’ experience with a
new wound measurement and documentation system, the ARANZ
Medical Silhouette Mobile™ (ARANZ Medical, Christchurch, New
Zealand). This innovative device combines a digital camera and structured
lighting in the form of 2 laser beams to automatically correct for
image scale and skin curvature, allowing rapid and accurate measurements
of the wound surface area and depth. The scanner unit plugs
into a standard personal digital assistant to form a portable device that
can be easily held and operated using 1 hand. The scanner has been
used in clinical practice trials in patients with venous leg ulcers, diabetic
foot ulcers, and in the community setting. The scanner was
found to be accurate and reliable, easy to learn and use, portable, and
compact. The results presented suggest that this device may be a
viable choice in the management of different types of chronic wounds
Dynamics and spin relaxation of tempone in a host crystal. An ENDOR, high field EPR and electron spin echo study
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/01/1999
- Field of study
We studied in the temperature range 4-300 K the dynamics and the electron spin echo decay of the radical 4-oxo-2,2,6,6,-tetramethyl-1-piperidinyloxyl (tempone) doping substitutionally a single crystal of the diketone 2,2,4,4-tetramethyl-cyclobutan-1,3-dione. Electron nuclear double resonance (ENDOR) and high field electron paramagnetic resonance (EPR) spectra (110 GHz) displayed three types of motion: interconversion between twisted-crossover conformations, rotation of the methyl groups and libration of the radical in the crystal matrix. At room temperature all the motions are fast, and they reach the slow motion regime each at a different temperature, being all slow below 80 K. An approximate value of 9 kJ mol(-1) for the energy barrier hindering the rotation of the tempone methyl groups is estimated. At low temperature their motion is too slow to give any contribution to the echo decay. The echo decays as a linear exponential in the range 100-300 K, due to the radical motions. At T<100 K the interaction with the methyl protons of the matrix is the dominant dephasing mechanism, and the echo decays as a gaussian. At T < 20 K it depends on the square root of the time. Echo decays and electron spin echo envelope modulations (ESEEM) are simulated by using the available theoretical models. A damping of ESEEM superimposed to the echo decay is discussed
Comparison of Attitudes between Generation X and Baby Boomer Veterinary Faculty and Residents
- Publication venue
- 'University of Toronto Press Inc. (UTPress)'
- Publication date
- Field of study
MRSA outbreak at a transplantation unit
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Methicillin-resistant Staphylococcus aureus (MRSA) infections frequently complicate the post-operative course of transplant recipients, and despite nasal carriage and endemic colonization, MRSA outbreaks are not commonly described. This study reports a case of MRSA outbreak and discusses infection control measures and recommendations for this situation
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