Effects of electron emission on plasma sheaths

Current state-of-the-art plasma thrusters are limited in power density and thrust density by power losses to plasma-facing walls and electrodes. In the case of Hall effect thrusters, power deposition to the discharge channel walls and anode negatively impact the efficiency of the thruster and limit the attainable power density and thrust density. The current work aims to recreate thruster-relevant wall-interaction physics in a quiescent plasma and investigate them using electrostatic probes, in order to inform the development of the next generation of high-power-density / high-thrust-density propulsion devices. Thruster plasma-wall interactions are complicated by the occurrence of the plasma sheath, a thin boundary layer that forms between a plasma and its bounding wall where electrostatic forces dominate. Sheaths have been recognized since the seminal work of Langmuir in the early 1900’s, and the theory of sheaths has been greatly developed to the present day. The theories are scalable across a wide range of plasma parameters, but due to the difficulty of obtaining experimental measurements of plasma properties in the sheath region, there is little experimental data available to directly support the theoretical development. Sheaths are difficult to measure in situ in thrusters due to the small physical length scale of the sheath (order of micrometers in thruster plasmas) and the harsh plasma environment of the thruster. Any sufficiently small probe will melt, and available optical plasma diagnostics do not have the sensitivity and/or spatial resolution to resolve the sheath region. The goal of the current work is to experimentally characterize plasma sheaths xxvi in a low-density plasma that yields centimeter-thick sheath layers. By generating thick sheaths, spatially-resolved data can obtained using electrostatic probes. The investigation focuses on the effects of electron emission from the wall and several factors that influence it, including wall material, wall temperature, wall surface roughness and topology, as well as the scaling of sheaths from the low-density plasma environment towards thruster conditions. The effects of electron emission and wall material are found to agree with classical fluid and kinetic theory extended from literature. In conditions of very strong emission from the wall, evidence is found for a full transition in sheath polarities rather than a non-monotonic structure. Wall temperature is observed to have no effect on the sheath over boron nitride walls independent of outgassing on initial heat-up, for sub-thermionic temperatures. Wall roughness is observed to postpone the effects of electron emission to higher plasma temperatures, indicating that the rough wall impairs the wall’s overall capacity to emit electrons. Reductions in electron yield are not inconsistent with a diffuse-emission geometric trapping model. Collectively, the experimental data provide an improved grounding for thruster modeling and design.Current state-of-the-art plasma thrusters are limited in power density and thrust density by power losses to plasma-facing walls and electrodes. In the case of Hall effect thrusters, power deposition to the discharge channel walls and anode negatively impact the efficiency of the thruster and limit the attainable power density and thrust density. The current work aims to recreate thruster-relevant wall-interaction physics in a quiescent plasma and investigate them using electrostatic probes, in order to inform the development of the next generation of high-power-density / high-thrust-density propulsion devices. Thruster plasma-wall interactions are complicated by the occurrence of the plasma sheath, a thin boundary layer that forms between a plasma and its bounding wall where electrostatic forces dominate. Sheaths have been recognized since the seminal work of Langmuir in the early 1900’s, and the theory of sheaths has been greatly developed to the present day. The theories are scalable across a wide range of plasma parameters, but due to the difficulty of obtaining experimental measurements of plasma properties in the sheath region, there is little experimental data available to directly support the theoretical development. Sheaths are difficult to measure in situ in thrusters due to the small physical length scale of the sheath (order of micrometers in thruster plasmas) and the harsh plasma environment of the thruster. Any sufficiently small probe will melt, and available optical plasma diagnostics do not have the sensitivity and/or spatial resolution to resolve the sheath region. The goal of the current work is to experimentally characterize plasma sheaths xxvi in a low-density plasma that yields centimeter-thick sheath layers. By generating thick sheaths, spatially-resolved data can obtained using electrostatic probes. The investigation focuses on the effects of electron emission from the wall and several factors that influence it, including wall material, wall temperature, wall surface roughness and topology, as well as the scaling of sheaths from the low-density plasma environment towards thruster conditions. The effects of electron emission and wall material are found to agree with classical fluid and kinetic theory extended from literature. In conditions of very strong emission from the wall, evidence is found for a full transition in sheath polarities rather than a non-monotonic structure. Wall temperature is observed to have no effect on the sheath over boron nitride walls independent of outgassing on initial heat-up, for sub-thermionic temperatures. Wall roughness is observed to postpone the effects of electron emission to higher plasma temperatures, indicating that the rough wall impairs the wall’s overall capacity to emit electrons. Reductions in electron yield are not inconsistent with a diffuse-emission geometric trapping model. Collectively, the experimental data provide an improved grounding for thruster modeling and design.Ph.D

Characterization of fast magnetosonic waves driven by interaction between magnetic fields and compact toroids

Magnetosonic waves are low-frequency, linearly polarized magnetohydrodynamic (MHD) waves that can be excited in any electrically conducting fluid permeated by a magnetic field. They are commonly found in space, responsible for many well-known features, such as heating of the solar corona and acceleration of energetic electrons in Earth's inner magnetosphere. In this work, we present observations of magnetosonic waves driven by injecting compact toroid (CT) plasmas into a static Helmholtz magnetic field at the Big Red Ball (BRB) Facility at Wisconsin Plasma Physics Laboratory (WiPPL). We first identify the wave modes by comparing the experimental results with the MHD theory, and then study how factors such as the background magnetic field affect the wave properties. Since this experiment is part of an ongoing effort of forming a target plasma with tangled magnetic fields as a novel fusion fuel for magneto-inertial fusion (MIF, aka magnetized target fusion), we also discuss a future possible path of forming the target plasma based on our current results

Ion Diffusion Velocity Measurements in a Multi-Ion-Species Plasma Shock

Collisional plasma shocks generated from supersonic flows are an important feature in many astrophysical and laboratory high-energy-density plasmas. Compared to single-ion-species plasma shocks, plasma shock fronts with multiple ion species contain additional structure, including interspecies ion separation driven by gradients in species concentration, temperature, pressure, and electric potential. We present time-resolved density and temperature measurements of two ion species in collisional plasma shocks produced by head-on merging of supersonic plasma jets, allowing determination of the diffusion velocity of the ion species. Our results demonstrate that the lighter ion species diffuse faster than the heavier species within a shock front, consistent with predictions from the inter-ion-species transport theory. Results from the experiment approach quantitative agreement with theoretical prediction and 1D ion-Fokker-Planck kinetic simulation

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors

We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), several analogues were identified with micromolar activity through targeted displacement of bound water molecules in the active site. Since the TDZ analogues showed reduced promiscuity compared to their 2,4-dianilinopyrimidine counter parts, they represent starting points for development of highly selective kinase inhibitors

Effect of amoxicillin on the gut microbiome of children with severe acute malnutrition in Madarounfa, Niger: A retrospective metagenomic analysis of a placebo-controlled trial

BACKGROUND: Children with severe acute malnutrition are treated with antibiotics as outpatients. We aimed to determine the effect of 7 days of amoxicillin on acute and long-term changes to the gut microbiome and antibiotic resistome in children treated for severe acute malnutrition. METHODS: We conducted a secondary analysis of a randomised, double-blinded, placebo-controlled trial (NCT01613547) of amoxicillin in children (aged 6-59 months) with severe acute malnutrition treated as outpatients in Madarounfa, Niger. We randomly selected 161 children from the overall cohort (n=2399) for initial 12-week follow-up from Sept 23, 2013 to Feb 3, 2014. We selected a convenience sample of those 161 children, on the basis of anthropometric measures, for follow-up 2 years later (Sept 28 to Oct 27, 2015). Children provided faecal samples at baseline, week 1, week 4, week 8, week 12, and, for those in the 2-year follow-up cohort, week 104. We conducted metagenomic sequencing followed by microbiome and resistome profiling of faecal samples. 38 children without severe acute malnutrition and six children with severe acute malnutrition matching the baseline ages of the original cohort were used as reference controls. FINDINGS: In the 12-week follow-up group, amoxicillin led to an immediate decrease in gut microbiome richness from 37·6 species (95% CI 32·6-42·7) and Shannon diversity index (SDI) 2·18 (95% CI 1·97-2·39) at baseline to 27·7 species (95% CI 22·9-32·6) species and SDI 1·55 (95% CI 1·35-1·75) at week 1. Amoxicillin increased gut antibiotic resistance gene abundance to 6044 reads per kilobase million (95% CI 4704-7384) at week 1, up from 4800 (3391-6208) at baseline, which returned to baseline 3 weeks later. 35 children were included in the 2-year follow-up; the amoxicillin-treated children (n=22) had increased number of species in the gut microbiome compared with placebo-treated children (n=13; 60·7 [95% CI 54·7-66·6] vs 36·9 [29·4-44·3]). Amoxicillin-treated children had increased Prevotella spp and decreased Bifidobacterium spp relative to age-matched placebo-treated children, indicating a more mature, adult-like microbiome. INTERPRETATION: Amoxicillin treatment led to acute but not sustained increases in antimicrobial resistance genes and improved gut microbiome maturation 2 years after severe acute malnutrition treatment. FUNDING: Bill & Melinda Gates Foundation; Médecins sans Frontières Operational Center Paris; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Edward Mallinckrodt Jr Foundation; Doris Duke Foundation

Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger.

BACKGROUND: In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine-pyrimethamine (AQ + SP) is recommended in the country to be administered monthly just before and during the rainy season. Moreover, clinical decisions on use of SP for intermittent preventive treatment in pregnancy (IPTp) now depend upon the validated molecular markers for SP resistance in Plasmodium falciparum observed in the local parasite population. However, little is known about molecular markers of resistance for either SP or AQ in the south of Niger. To address this question, clinical samples which met clinical and biological criteria, were collected in Gabi, Madarounfa district, Maradi region, Niger in 2011-2012 (before SMC implementation). Molecular markers of resistance to pyrimethamine (pfdhfr), sulfadoxine (pfdhps) and amodiaquine (pfmdr1) were assessed by DNA sequencing. RESULTS: Prior to SMC implementation, the samples showed a high proportion of clinical samples that carried the pfdhfr 51I/59R/108N haplotype associated with resistance to pyrimethamine and pfdhps 436A/F/H and 437G mutations associated with reduced susceptibility to sulfadoxine. In contrast mutations in codons 581G, and 613S in the pfdhps gene, and in pfmdr1, 86Y, 184Y, 1042D and 1246Y associated with resistance to amodiaquine, were less frequently observed. Importantly, pfdhfr I164L and pfdhps K540E mutations shown to be the most clinically relevant markers for high level clinical resistance to SP were not detected in Gabi. CONCLUSIONS: Although parasites with genotypes associated with the highest levels of resistance to AQ + SP are not yet common in this setting, their importance for deployment of SMC and IPTp dictates that monitoring of these markers of resistance should accompany these interventions. This study also highlights the parasite heterogeneity within a small spatial area and the need to use caution when extrapolating results from surveys of molecular markers of resistance in a single site to inform regional policy decisions