161 research outputs found
Early acute microvascular kidney transplant rejection in the absence of anti-HLA antibodies is associated with preformed IgG antibodies against diverse glomerular endothelial cell antigens
International audienceBACKGROUND: Although anti-HLA antibodies (Abs) cause most antibody-mediated rejections of renal allografts, non-anti-HLA Abs have also been postulated to contribute. A better understanding of such Abs in rejection is needed.METHODS: We conducted a nationwide study to identify kidney transplant recipients without anti-HLA donor-specific Abs who experienced acute graft dysfunction within 3 months after transplantation and showed evidence of microvascular injury, called acute microvascular rejection (AMVR). We developed a crossmatch assay to assess serum reactivity to human microvascular endothelial cells, and used a combination of transcriptomic and proteomic approaches to identify non-HLA Abs.RESULTS: We identified a highly selected cohort of 38 patients with early acute AMVR. Biopsy specimens revealed intense microvascular inflammation and the presence of vasculitis (in 60.5%), interstitial hemorrhages (31.6%), or thrombotic microangiopathy (15.8%). Serum samples collected at the time of transplant showed that previously proposed anti-endothelial cell Abs-angiotensin type 1 receptor (AT1R), endothelin-1 type A and natural polyreactive Abs-did not increase significantly among patients with AMVR compared with a control group of stable kidney transplant recipients. However, 26% of the tested AMVR samples were positive for AT1R Abs when a threshold of 10 IU/ml was used. The crossmatch assay identified a common IgG response that was specifically directed against constitutively expressed antigens of microvascular glomerular cells in patients with AMVR. Transcriptomic and proteomic analyses identified new targets of non-HLA Abs, with little redundancy among individuals.CONCLUSIONS: Our findings indicate that preformed IgG Abs targeting non-HLA antigens expressed on glomerular endothelial cells are associated with early AMVR, and that cell-based assays are needed to improve risk assessments before transplant
Durkheim et le retour de l'individualisme / Durkheim and the Return of Individualism
Ladrière Paul. Durkheim et le retour de l'individualisme / Durkheim and the Return of Individualism. In: Archives de sciences sociales des religions, n°69, 1990. Relire Durkheim. pp. 147-150
Legrand (Michel) Colonisation portugaise et discours religieux
Ladrière Paul. Legrand (Michel) Colonisation portugaise et discours religieux . In: Archives de sciences sociales des religions, n°38, 1974. pp. 212-213
Balthasar (Hans Urs von) Le Complexe antiromain
Ladrière Paul. Balthasar (Hans Urs von) Le Complexe antiromain. In: Archives de sciences sociales des religions, n°43/2, 1977. pp. 208-209
Christianisme sans idéologie
Ladrière Paul. Christianisme sans idéologie. In: Archives de sciences sociales des religions, n°42, 1976. pp. 294-295
Garrone (Gabriel-Marie) Cardinal L'Eglise 1965-1972
Ladrière Paul. Garrone (Gabriel-Marie) Cardinal L'Eglise 1965-1972. In: Archives de sociologie des religions, n°34, 1972. p. 200
Humanisme et théologie
Ladrière Paul. Humanisme et théologie. In: Archives de sciences sociales des religions, n°42, 1976. p. 253
Garrone (Gabriel-Marie) Cardinal L'Eglise 1965-1972
Ladrière Paul. Garrone (Gabriel-Marie) Cardinal L'Eglise 1965-1972. In: Archives de sociologie des religions, n°34, 1972. p. 200
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