Automated Discrimination of Brain Pathological State Attending to Complex Structural Brain Network Properties: The Shiverer Mutant Mouse Case

Neuroimaging classification procedures between normal and pathological subjects are sparse and highly dependent of an expert's clinical criterion. Here, we aimed to investigate whether possible brain structural network differences in the shiverer mouse mutant, a relevant animal model of myelin related diseases, can reflect intrinsic individual brain properties that allow the automatic discrimination between the shiverer and normal subjects. Common structural networks properties between shiverer (C3Fe.SWV Mbpshi/Mbpshi, n = 6) and background control (C3HeB.FeJ, n = 6) mice are estimated and compared by means of three diffusion weighted MRI (DW-MRI) fiber tractography algorithms and a graph framework. Firstly, we found that brain networks of control group are significantly more clustered, modularized, efficient and optimized than those of the shiverer group, which presented significantly increased characteristic path length. These results are in line with previous structural/functional complex brain networks analysis that have revealed topologic differences and brain network randomization associated to specific states of human brain pathology. In addition, by means of network measures spatial representations and discrimination analysis, we show that it is possible to classify with high accuracy to which group each subject belongs, providing also a probability value of being a normal or shiverer subject as an individual anatomical classifier. The obtained correct predictions (e.g., around 91.6–100%) and clear spatial subdivisions between control and shiverer mice, suggest that there might exist specific network subspaces corresponding to specific brain disorders, supporting also the point of view that complex brain network analyses constitutes promising tools in the future creation of interpretable imaging biomarkers

Patogenicidade do Fungo Entomopatogeno Nomuraea Rileyi (Farlow) Samson Apos Seis Anos de Armazenamento.

Lagartas de Anticarsia gemmatalis Hubner (Lep.: Noctuidae), de seis municipios, mortas, e recobertas por conidios de Nomuraea rileyi (Farlow) Samson foram colocadas dentro de capsulas de gelatina. As capsulas, dentro de vidros fechados contendo silica, foram mantidas a -18°C, de 1984 a 1990. Os inoculos mantiveram-se viaveis a patogenicos ate apos este periodo.Made available in DSpace on 2011-04-09T12:13:09Z (GMT). No. of bitstreams: 1 pab03set93.pdf: 1359542 bytes, checksum: 977fad12ff8b797c6edf7cfece5393a9 (MD5) Previous issue date: 2001-08-16199

Estimativas de parâmetros genéticos na variedade de milho BR-5011 Sertanejo no Nordeste brasileiro.

From 1996 to 1998, three cycles of selection were carried out among half-sib families within the maize cv. BR5011-Sertanejo in northeastern Brazil. During each cycle, 196 half-sib families were evaluated by utilizing a 14 x 14 simple lattice design. The best families were recombined within the same agricultural year, thus allowing one generation to be obtained per year. Observations indicated that BR5011-Sertanejo possessed enough genetic variation to produce increments in green yield, indicating that BR5011-Sertanejo can be used as an alternative to the varieties grown in the northeastern region. Significant genotype x environment interaction indicated that the selection process needs to be conducted in different environments to improve the efficiency of family selection so that consistent estimates of genetic variance components can be obtained..Made available in DSpace on 2012-09-18T01:07:44Z (GMT). No. of bitstreams: 1 Estimativasparametros1.pdf: 5674664 bytes, checksum: 924cf551cefee4e7a16de8de8ad029e4 (MD5) Previous issue date: 2006-01-26199

Estimativas de parâmetros geneticos em ciclos avançados de seleção entre e dentro de progênies de meios-irmãos na variedade de milho BR 5028 São Francisco.

No período de 1999 a 200 I, a variedade de milho BR 5028 São Francisco foi submetida aos ciclos XIII, XIV e XV de seleção entre e dentro de progênies de meios-irmãos, no Nordeste brasileiro, visando obter estimativas de parâmetros genéticos, para posterior verificação do comportamento da variabilidade genética. As 196 progênies de cada ciclo foram avaliadas em blocos ao acaso, com duas repetições, realizando-se as recombinações das progênies selecionadas dentro do mesmo ano agrícola, de modo a se obter um ciclo por ano. As análises de variância conjuntas mostraram diferenças entre as progênies de cada ciclo, evidenciando-se a presença de variabilidade genética entre elas. Foram observados acréscimos da variabilidade genética à medida que se avançaram os ciclos de seleção. As altas magnitudes das estimativas dos parâmetros genéticos, associadas às altas médias de produtividades das progênies e ao ganho genético médio esperado com a seleção entre e dentro de progênies de meios-irmãos, por ciclo de seleção, (15.18%), evidenciam o grande potencial da variedade em responder à seleção, o que permitirá a obtenção de ganhos para a produtividade de espigas com o desenvolver de novos ciclos de seleção.200