12 research outputs found
Efficiency of application of different DNA probes in identifying marker chromosomes
The presence of marker chromosomes in the human karyotype always requires a special diagnostic approach. Determination of the marker chromosome type and structure is of great diagnostic and prognostic importance. There are several methods of marker chromosomes identification, which differ in their informative value. The paper presents the results of cytogenetic and FISH diagnostics of supernumerical marker chromosomes (SMC) cases in patientsβ karyotype. Aim. To analyze the results of the cytogenetic and molecular cytogenetic diagnostics for patients with marker chromosomes, and to evaluate and compare the efficiency of the methods used. Methods. Karyotyping was done according to the standard methods. GTG, CBG, QFQ and NOR-Ag methods of differential staining were used. FISH was performed according to the manufacturerβs instructions for CEP, LSI and WCP DNA-probes. Results. Marker chromosome was found in 15 of 7989 patients. Application of standard staining methods was effective in 66.6 % of cases. Combination of differential staining and FISH allowed identifying a marker chromosome in 83.3 %. 90 % of all marker chromosomes were identified as isochromosomes and 60 % of them were derivative from chromosome 15. Conclusions. The use of WCP probes is a main step in the marker chromosome identification with further application of CEP/LSI probes. If a marker chromosome has nonspecific DNA sequences more sensitive methods should be use.ΠΠ°ΡΠ²Π½ΡΡΡΡ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΈΡ
Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌ Π² ΠΊΠ°ΡΡΠΎΡΠΈΠΏΡ Π»ΡΠ΄ΠΈΠ½ΠΈ Π·Π°Π²ΠΆΠ΄ΠΈ Π²ΠΈΠΌΠ°Π³Π°Ρ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΠ³ΠΎ Π΄ΡΠ°Π³Π½ΠΎΡΡΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠ΄Ρ
ΠΎΠ΄Ρ. ΠΠΈΠ·Π½Π°ΡΠ΅Π½Π½Ρ ΡΠΈΠΏΡ Ρ ΡΡΡΡΠΊΡΡΡΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΎΡ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠΈ ΠΌΠ°Ρ Π²Π΅Π»ΠΈΠΊΠ΅ Π΄ΡΠ°Π³Π½ΠΎΡΡΠΈΡΠ½Π΅ Ρ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ½Π΅ Π·Π½Π°ΡΠ΅Π½Π½Ρ. ΠΡΠ½ΡΡ ΠΊΡΠ»ΡΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄ΡΠ² ΡΠ΄Π΅Π½ΡΠΈΡΡΠΊΠ°ΡΡΡ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΈΡ
Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌ, Π°Π»Π΅ ΡΡΠ·Π½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈ ΠΌΠ°ΡΡΡ ΡΡΠ·Π½ΠΈΠΉ ΡΡΠ²Π΅Π½Ρ ΡΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΡΡΡ. Π ΡΠΎΠ±ΠΎΡΡ Π½Π°Π²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ½ΠΎΡ ΡΠ° FISH Π΄ΡΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π²ΠΈΠΏΠ°Π΄ΠΊΡΠ² ΡΠ· Π½Π°Π΄ΡΠΈΡΠ΅Π»ΡΠ½ΠΈΠΌΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΈΠΌΠΈ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ°ΠΌΠΈ Π² ΠΊΠ°ΡΡΠΎΡΠΈΠΏΡ ΠΏΠ°ΡΡΡΠ½ΡΡΠ². ΠΠ΅ΡΠ°. ΠΠ½Π°Π»ΡΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡΠ² ΡΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ½ΠΈΡ
Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-ΡΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ½ΠΈΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ ΠΊΠ°ΡΡΠΎΡΠΈΠΏΡΠ² ΠΏΠ°ΡΡΡΠ½ΡΡΠ² Π· ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΈΠΌΠΈ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ°ΠΌΠΈ, Π° ΡΠ°ΠΊΠΎΠΆ ΠΎΡΡΠ½ΠΊΠ° Ρ ΠΏΠΎΡΡΠ²Π½ΡΠ½Π½Ρ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½ΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΡΠ². ΠΠ΅ΡΠΎΠ΄ΠΈ. ΠΠ°ΡΡΠΎΡΠΈΠΏΡΠ²Π°Π½Π½Ρ Π±ΡΠ»ΠΎ Π²ΠΈΠΊΠΎΠ½Π°Π½ΠΎ Ρ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΎΡΡΡ Π΄ΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΡΠ². ΠΡΠ»ΠΈ Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½Ρ GTG, CBG, QFQ Ρ NOR-Ag ΠΌΠ΅ΡΠΎΠ΄ΠΈ Π΄ΠΈΡΠ΅ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΡΠ±ΡΠ²Π°Π½Π½Ρ. FISH Π±ΡΠ»Π° Π²ΠΈΠΊΠΎΠ½Π°Π½Π° Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΎ Π΄ΠΎ ΡΠ½ΡΡΡΡΠΊΡΡΠΉ Π²ΠΈΡΠΎΠ±Π½ΠΈΠΊΠ° Π΄Π»Ρ CEP, LSI ΡΠ° WCP ΠΠΠ-ΠΏΡΠΎΠ±. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ. ΠΠ°ΡΠΊΠ΅ΡΠ½Π° Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ° Π±ΡΠ»Π° Π²ΠΈΡΠ²Π»Π΅Π½Π° Ρ 15 Π· 7989 ΠΏΠ°ΡΡΡΠ½ΡΡΠ². ΠΠ°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΡΠ² ΡΠ°ΡΠ±ΡΠ²Π°Π½Π½Ρ Π±ΡΠ»ΠΎ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΈΠΌ Ρ 66,6% Π²ΠΈΠΏΠ°Π΄ΠΊΡΠ². ΠΠΎΡΠ΄Π½Π°Π½Π½Ρ Π΄ΠΈΡΠ΅ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΡΠ±ΡΠ²Π°Π½Π½Ρ ΡΠ° FISH Π΄ΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΡΠ΄Π΅Π½ΡΠΈΡΡΠΊΡΠ²Π°ΡΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠ½Ρ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠΈ Ρ 83,3 %. 90 % Π²ΡΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΈΡ
Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌ Π±ΡΠ»ΠΈ Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Ρ ΡΠΊ ΡΠ·ΠΎΡ
ΡΠΎΠΌΠΎΡΠΎΠΌΠΈ Ρ 60 % Π· Π½ΠΈΡ
Π±ΡΠ»ΠΈ ΠΏΠΎΡ
ΡΠ΄Π½ΠΈΠΌΠΈ Π²ΡΠ΄ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠΈ 15. ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΠΈΠΊΠΎΡΠΈΡΡΠ°Π½Π½Ρ WCP ΠΠΠ-ΠΏΡΠΎΠ± Ρ ΠΎΡΠ½ΠΎΠ²Π½ΠΈΠΌ Π΅ΡΠ°ΠΏΠΎΠΌ ΡΠ΄Π΅Π½ΡΠΈΡΡΠΊΠ°ΡΡΡ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΈΡ
Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌ Π· Π½Π°ΡΡΡΠΏΠ½ΠΈΠΌ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½ΡΠΌ CEP ΡΠ° LSI ΠΠΠ-ΠΏΡΠΎΠ±. Π―ΠΊΡΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠ½Π° Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ° ΠΌΠ°Ρ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΡΡΠ½Ρ ΠΏΠΎΡΠ»ΡΠ΄ΠΎΠ²Π½ΠΎΡΡΡ ΠΠΠ, ΡΠΎ Ρ ΡΠ°ΠΊΠΈΡ
Π²ΠΈΠΏΠ°Π΄ΠΊΠ°Ρ
ΠΏΠΎΠ²ΠΈΠ½Π½Ρ Π±ΡΡΠΈ Π·Π°ΡΡΠΎΡΠΎΠ²Π°Π½Ρ Π±ΡΠ»ΡΡ ΡΡΡΠ»ΠΈΠ²Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈ.ΠΠ°Π»ΠΈΡΠΈΠ΅ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΡΡ
Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌ Π² ΠΊΠ°ΡΠΈΠΎΡΠΈΠΏΠ΅ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π²ΡΠ΅Π³Π΄Π° ΡΡΠ΅Π±ΡΠ΅Ρ ΠΎΡΠΎΠ±ΠΎΠ³ΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π°. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΈΠΏΠ° ΠΈ ΡΡΡΡΠΊΡΡΡΡ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΎΠΉ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΡ ΠΈΠΌΠ΅Π΅Ρ Π±ΠΎΠ»ΡΡΠΎΠ΅ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅. Π‘ΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΡΡ
Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌ, Π½ΠΎ ΡΠ°Π·Π½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈΠΌΠ΅ΡΡ ΡΠ°Π·Π½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΡΡΠΈ. Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ FISH Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΠ»ΡΡΠ°Π΅Π² ΡΠΎ ΡΠ²Π΅ΡΡ
ΡΠΈΡΠ»Π΅Π½Π½ΡΠΌΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΡΠΌΠΈ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ°ΠΌΠΈ Π² ΠΊΠ°ΡΠΈΠΎΡΠΈΠΏΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². Π¦Π΅Π»Ρ. ΠΠ½Π°Π»ΠΈΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-ΡΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΊΠ°ΡΠΈΠΎΡΠΈΠΏΠΎΠ² ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΡΠΌ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ°ΠΌΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΡΠ΅Π½ΠΊΠ° ΠΈ ΡΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ². ΠΠ΅ΡΠΎΠ΄Ρ. ΠΠ°ΡΠΈΠΎΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ ΡΠΎΠ³Π»Π°ΡΠ½ΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊ. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ GTG, CBG, QFQ ΠΈ NOR-Ag ΠΌΠ΅ΡΠΎΠ΄Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΡ. FISH Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΠΈΠ½ΡΡΡΡΠΊΡΠΈΡΠΌΠΈ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ Π΄Π»Ρ CEP, LSI ΠΈ WCP ΠΠΠ-ΠΏΡΠΎΠ±. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ°ΡΠΊΠ΅ΡΠ½Π°Ρ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ° ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° Ρ 15 ΠΈΠ· 7989 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΡ Π±ΡΠ»ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ Π² 66,6 % ΡΠ»ΡΡΠ°Π΅Π². Π‘ΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΡ ΠΈ FISH ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°ΡΡ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΡΠ΅ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΡ Π² 83,3 %. 90 % Π²ΡΠ΅Ρ
ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΡΡ
Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌ Π±ΡΠ»ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΊΠ°ΠΊ ΠΈΠ·ΠΎΡ
ΡΠΎΠΌΠΎΡΠΎΠΌΡ ΠΈ 60 % ΠΈΠ· Π½ΠΈΡ
Π±ΡΠ»ΠΈ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠΌΠΈ ΠΎΡ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΡ 15. ΠΡΠ²ΠΎΠ΄Ρ. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ WCP ΠΠΠ-ΠΏΡΠΎΠ± ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌ ΡΡΠ°ΠΏΠΎΠΌ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΡΡ
Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌ Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ CEP ΠΈ LSI ΠΠΠ-ΠΏΡΠΎΠ±. ΠΡΠ»ΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠ½Π°Ρ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ° ΠΈΠΌΠ΅Π΅Ρ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΠΠ, ΡΠΎ Π² ΡΠ°ΠΊΠΈΡ
ΡΠ»ΡΡΠ°ΡΡ
Π΄ΠΎΠ»ΠΆΠ½Ρ Π±ΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½Ρ Π±ΠΎΠ»Π΅Π΅ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ
Ultrarelativistic electron-hole pairing in graphene bilayer
We consider ground state of electron-hole graphene bilayer composed of two
independently doped graphene layers when a condensate of spatially separated
electron-hole pairs is formed. In the weak coupling regime the pairing affects
only conduction band of electron-doped layer and valence band of hole-doped
layer, thus the ground state is similar to ordinary BCS condensate. At strong
coupling, an ultrarelativistic character of electron dynamics reveals and the
bands which are remote from Fermi surfaces (valence band of electron-doped
layer and conduction band of hole-doped layer) are also affected by the
pairing. The analysis of instability of unpaired state shows that s-wave
pairing with band-diagonal condensate structure, described by two gaps, is
preferable. A relative phase of the gaps is fixed, however at weak coupling
this fixation diminishes allowing gapped and soliton-like excitations. The
coupled self-consistent gap equations for these two gaps are solved at zero
temperature in the constant-gap approximation and in the approximation of
separable potential. It is shown that, if characteristic width of the pairing
region is of the order of magnitude of chemical potential, then the value of
the gap in the spectrum is not much different from the BCS estimation. However,
if the pairing region is wider, then the gap value can be much larger and
depends exponentially on its energy width.Comment: 13 pages with 8 figures; accepted to Eur. Phys. J.
Multi-wavelength observations of blazar AO 0235+164 in the 2008-2009 flaring state
The blazar AO 0235+164 (z = 0.94) has been one of the most active objects observed by Fermi Large Area Telescope (LAT) since its launch in Summer 2008. In addition to the continuous coverage by Fermi, contemporaneous observations were carried out from the radio to Ξ³-ray bands between 2008 September and 2009 February. In this paper, we summarize the rich multi-wavelength data collected during the campaign (including F-GAMMA, GASP-WEBT, Kanata, OVRO, RXTE, SMARTS, Swift, and other instruments), examine the cross-correlation between the light curves measured in the different energy bands, and interpret the resulting spectral energy distributions in the context of well-known blazar emission models. We find that the Ξ³-ray activity is well correlated with a series of near-IR/optical flares, accompanied by an increase in the optical polarization degree. On the other hand, the X-ray light curve shows a distinct 20 day high state of unusually soft spectrum, which does not match the extrapolation of the optical/UV synchrotron spectrum. We tentatively interpret this feature as the bulk Compton emission by cold electrons contained in the jet, which requires an accretion disk corona with an effective covering factor of 19% at a distance of 100 R g. We model the broadband spectra with a leptonic model with external radiation dominated by the infrared emission from the dusty torus. Β© 2012. The American Astronomical Society. All rights reserved
Insights into the high-energy Ξ³-ray emission of Markarian 501 from extensive multifrequency observations in the Fermi era
We report on the Ξ³-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average Large Area Telescope (LAT) Ξ³-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 Β± 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of two), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 Β± 0.14, and the softest one is 2.51 Β± 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3 GeV. In this paper, we also present the first results from the 4.5 month long multifrequency campaign (2009 March 15-August 1) on Mrk 501, which included the Very Long Baseline Array (VLBA), Swift, RXTE, MAGIC, and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The extensive radio to TeV data set from this campaign provides us with the most detailed spectral energy distribution yet collected for this source during its relatively low activity. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton (SSC) model. In the framework of this model, we find that the dominant emission region is characterized by a size β²0.1 pc (comparable within a factor of few to the size of the partially resolved VLBA core at 15-43 GHz), and that the total jet power (β1044 erg s-1) constitutes only a small fraction (βΌ10-3) of the Eddington luminosity. The energy distribution of the freshly accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3 GeV-10 TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20 GeV. We argue that such a form is consistent with a scenario in which the bulk of the energy dissipation within the dominant emission zone of Mrk 501 is due to relativistic, proton-mediated shocks. We find that the ultrarelativistic electrons and mildly relativistic protons within the blazar zone, if comparable in number, are in approximate energy equipartition, with their energy dominating the jet magnetic field energy by about two orders of magnitude. Β© 2011. The American Astronomical Society
Collective properties of triplet excitons in heterostructures based on ferromagnetic semiconductors
Resonance excitation of excitons in a semiconductor by ultrashort frequency-tunable light pulses
Tunneling ionization of deep centers in high-frequency electric fields
A theoretical and experimental study of the tunneling ionization of deep impurities in semiconductors has
been carried out for high-frequency alternating electric fields. It is shown that tunneling ionization occurs by
phonon-assisted tunneling which proceeds at high electric field strengths into direct tunneling without involving
phonons. In the quasistatic regime of low frequencies the tunneling probability is independent of frequency.
Raising the frequency leads to an enhancement of the tunneling ionization. The transition from the quasistatic
limit to frequency-dependent tunneling is determined by the tunneling time which, in the case of impurities
interacting with thermal phonons, is controlled by the temperature. In both the quasistatic and high-frequency
limits, the application of an external magnetic field perpendicular to the electric field reduces the ionization
probability when the cyclotron frequency becomes larger than the reciprocal tunneling time