293 research outputs found
Etudes in situ de la formation du carbonate de calcium CaCO3 synthétisé en milieu aqueux sous pression de CO2
National audienc
Microencapsulation of Proteins within Polymeric and Inorganic Particles using Supercritical CO2 Media
International audienc
Si-HPMC hydrogel combining CaCO3 microparticles as hybrid biomaterial for bone and cartilage tissue engineering
National audienc
Encapsulation de proteins thérapeutiques dans des microspheres de CaCO3 élaborées en milieu CO2 supercritique
National audienc
Microencapsulation of proteins within CaCO3 microspheres using supercritical CO2 media
International audienc
Encapsulation of growth factors into calcium carbonate microparticles elaborated in supercritical CO2 medium
National audienc
Encapsulation of protein into calcium carbonate microparticles elaborated in supercritical CO2 medium
National audienc
Supercritical CO2 as highly efficient innovative process for proteins encapsulation
International audienc
Development of a supercritical precipitation process of calcium carbonate for biomedical applications
International audienc
Lysozyme encapsulation within PLGA and CaCO3 microparticles using supercritical CO2 medium
This study is part of a global project which aims at conceiving and characterizing implantable synthetic extracellular matrices seeded with multifunctional particles for bone and cartilage tissue engineering. To date, protein encapsulation remains a challenge in the field of microencapsulation. The aim of this work is to use supercritical CO2 to generate polymeric and inorganic particles for protein encapsulation. Poly(lactic-co-glycolic) (PLGA) and calcium carbonate (CaCO3) microparticles were chosen to be investigated. In both cases, spherical particles were successfully obtained based on the formation of an emulsion in CO2 media. Most importantly, only non-toxic solvents or aqueous solution were used for the formulation of microparticles. Encapsulation experiments were carried out to provide a proof of concept. Lysozyme was chosen as a model protein and experimental designs were made in order to better understand the system and to better predict the encapsulation yield. The encapsulation yield can reach about 60% in both cases. The mechanism of particle formation and lysozyme encapsulation will also be discussed in detail
- …