9 research outputs found
SOLAR ACTIVITY AND PECULIARITIES OF THE RHEOLOGICAL PROPERTIES OF THE BLOOD IN PATIENTS WITH ANGINA PECTORIS
The peculiarities of the rheological properties of the blood are studied in patients with non-stable angina pectohs in different perbds of solar activity. It has been established, that in high solar activity hemorheological disorders are characterized by increase of blood viscosity and compensatory decrease oferythrocyte aggregation and increase of their deformation. In low solar activity less perceptible hyperviscositywas accompanied by significant increase oferythrocyte aggregation and decrease of their deformity capacity
Scientific and practical contribution of professor S.A. Georgieva to development of Russian physiology (dedicated to the 100-th Anniversary)
The article presents the most significant facts from biography of professor S.A. Georgieva. S.A. Georgieva made a great contribution by her scientific, pedagogical and public work to the development of Saratov medical institute. Her research work was directed to the study of hemostasi
ΠΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π½Π΅ΠΉΡΠΎΠ³Π΅Π½Π΅Π· - ΠΊΠ»ΡΡΠ΅Π²ΠΎΠ΅ Π·Π²Π΅Π½ΠΎ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π° ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΉ Π°Π΄Π΅Π½ΠΎΠΌΠΈΠΎΠ·ΠΎΠΌ
Objective. To study morphological features of the myometrium neural apparatus in women with chronic pelvic pain syndrome associated with adenomyosis. Methods. 60 biopsy samples were studied, which were obtained from hysterectomies for grade I-III diffuse adenomyosis associated with severe pelvic pain syndrome. These women did not receive any hormonal therapy. The control group included 10 biopsies obtained from women with adenomyosis who had no pelvic pain syndrome and underwent a surgery for abnormal uterine bleeding. These women did not receive any hormonal therapy either. After hysterectomy, uterine wall samples including endometrium and myometrium were fixed in 10% neutral, buffered formalin (pH 7.4) for 24 hours. After dehydration, the material was embedded in paraffin highly purified with polymeric additives (Richard-Allan Scientific, USA) at a temperature 2 in the glandular zone and 9.2 Β± 0.6 per mm2 in the stroma. Thin nerve fibers were visualized mainly in the stroma around blood vessels associated with the ectopic endometrium ingrowth zone. A dense plexus of thin nerve fibers was also found in the subserosal layer. Furthermore, both in myometrial subserosal and submucosal layers, ramified, thin nerve fibers predominated. The number of such fibers was significantly greater than in the comparison group (17.2 Β± 1.4 vs. 11.8 Β± 0.9 per mm2, p2 ΡΡΠ΅Π·Π°, Π² ΡΡΡΠΎΠΌΠ΅ - 9,2 Β± 0,6. Π’ΠΎΠ½ΠΊΠΈΠ΅ Π½Π΅ΡΠ²Π½ΡΠ΅ Π²ΠΎΠ»ΠΎΠΊΠ½Π° Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π»ΠΈΡΡ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π² ΡΡΡΠΎΠΌΠ΅ Π²ΠΎΠΊΡΡΠ³ ΠΊΡΠΎΠ²Π΅Π½ΠΎΡΠ½ΡΡ
ΡΠΎΡΡΠ΄ΠΎΠ², ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠΈΡ
Π·ΠΎΠ½Ρ Π²ΡΠ°ΡΡΠ°Π½ΠΈΡ ΡΠΊΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΡ. ΠΡΡΡΠΎΠ΅ ΡΠΏΠ»Π΅ΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ½ΠΊΠΈΡ
Π½Π΅ΡΠ²Π½ΡΡ
Π²ΠΎΠ»ΠΎΠΊΠΎΠ½ ΡΠ°ΠΊΠΆΠ΅ Π±ΡΠ»ΠΎ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ Π² ΡΡΠ±ΡΠ΅ΡΠΎΠ·Π½ΠΎΠΌ ΡΠ»ΠΎΠ΅. ΠΡΠΈΡΠ΅ΠΌ, ΠΊΠ°ΠΊ Π² ΡΡΠ±ΡΠ΅ΡΠΎΠ·Π½ΠΎΠΌ, ΡΠ°ΠΊ ΠΈ Π² ΠΏΠΎΠ΄ΡΠ»ΠΈΠ·ΠΈΡΡΠΎΠΌ ΡΠ»ΠΎΠ΅ ΠΌΠΈΠΎΠΌΠ΅ΡΡΠΈΡ ΠΏΡΠ΅Π²Π°Π»ΠΈΡΠΎΠ²Π°Π»ΠΈ ΡΠ°Π·Π²Π΅ΡΠ²Π»Π΅Π½Π½ΡΠ΅ ΡΠΎΠ½ΠΊΠΈΠ΅ Π½Π΅ΡΠ²Π½ΡΠ΅ Π²ΠΎΠ»ΠΎΠΊΠ½Π°, ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΊΠΎΡΠΎΡΡΡ
ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎ (p2. Π‘ΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΠΈΠ½Π½Π΅ΡΠ²Π°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ° ΠΌΠ°ΡΠΊΠΈ Ρ ΠΆΠ΅Π½ΡΠΈΠ½ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ Π°Π΄Π΅Π½ΠΎΠΌΠΈΠΎΠ·ΠΎΠΌ Ρ Π±ΠΎΠ»Π΅Π²ΡΠΌ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΡΠ²Π΅ΡΠΆΠ΄Π°ΡΡ, ΡΡΠΎ ΠΈΠΌΠ΅Π½Π½ΠΎ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ ΠΈΠ½Π½Π΅ΡΠ²Π°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ Π² ΠΌΠΈΠΎΠΌΠ΅ΡΡΠΈΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²Π΅ΡΠΎΡΡΠ½ΠΎΠΉ ΠΏΡΠΈΡΠΈΠ½ΠΎΠΉ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ Π°Π΄Π΅Π½ΠΎΠΌΠΈΠΎΠ·ΠΎΠΌ. ΠΡΠ²ΠΎΠ΄Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΡΠΎΠ΄Π΅Π»Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ, ΡΡΠΎ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌ ΠΌΠ΅ΡΡΠΎΠΌ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π½Π΅ΡΠ²ΠΎΠ² Π² ΠΌΠ°ΡΠΊΠ΅ ΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΈΡΠΈΠ½ΠΎΠΉ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π³ΠΈΠΏΠ΅ΡΠ°Π»Π³Π΅Π·ΠΈΠΈ ΠΏΡΠΈ Π°Π΄Π΅Π½ΠΎΠΌΠΈΠΎΠ·Π΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΌΠΈΠΎΠΌΠ΅ΡΡΠΈΠΉ Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π°Π½ΠΎΠΌΠ°Π»ΡΠ½ΠΎ ΠΈΠ·Π±ΡΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈΠ½Π½Π΅ΡΠ²Π°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ° Π²ΠΎΠΊΡΡΠ³ ΠΎΡΠ°Π³ΠΎΠ² ΡΠΊΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΡ, Π² ΠΏΠ΅ΡΠΈΠ²Π°ΡΠΊΡΠ»ΡΡΠ½ΡΡ
ΡΠ΅Π³ΠΈΠΎΠ½Π°Ρ
ΠΈ Π² ΡΡΡΠΎΠΌΠ΅ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΡΡΠΊΠ°ΠΌΠΈ Π³Π»Π°Π΄ΠΊΠΈΡ
ΠΌΠΈΠΎΡΠΈΡΠΎΠ²
Combination therapeutic options in the treatment of the luteal phase deficiency
Luteal phase deficiency (LPD) is described as a condition of insufficient progesterone exposure to maintain a regular secretory endometrium and allow for normal embryo implantation and growth. There is evidence that both follicular and luteal phase abnormalities can result in LPD cycles. The aim of this randomized prospective noncomparative study is to evaluate the effectiveness of combination therapy in patients with LPD. This prospective study included 35 women of the reproductive age. They were diagnosed with the LPD with sonographically and laboratory-verified methods. The age of patients was 36 Β± 0.46 years. The results of the study sonographically demonstrated an increase in the diameter of the corpus luteum from 1.36 Β± 0.32 (initially) to 2.16 Β± 0.21 mm after combination therapy. In addition, there was a statistically significant increase in the level of estrogens and progesterone in the corresponding phases of the menstrual cycle. Thus, the combination therapy for patients with LPD contributes to the recovery of cyclic events in the hypothalamic-pituitary-gonadal system, which determines the restoration of the endocrine function of the ovaries and promotes adequate secretory rearrangement of the endometrium in women of reproductive age. Β© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the UR MED GRUPP (LLC)
ΠΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π½Π΅ΠΉΡΠΎΠ³Π΅Π½Π΅Π· - ΠΊΠ»ΡΡΠ΅Π²ΠΎΠ΅ Π·Π²Π΅Π½ΠΎ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π° ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΉ Π°Π΄Π΅Π½ΠΎΠΌΠΈΠΎΠ·ΠΎΠΌ
Objective. To study morphological features of the myometrium neural apparatus in women with chronic pelvic pain syndrome associated with adenomyosis. Methods. 60 biopsy samples were studied, which were obtained from hysterectomies for grade I-III diffuse adenomyosis associated with severe pelvic pain syndrome. These women did not receive any hormonal therapy. The control group included 10 biopsies obtained from women with adenomyosis who had no pelvic pain syndrome and underwent a surgery for abnormal uterine bleeding. These women did not receive any hormonal therapy either. After hysterectomy, uterine wall samples including endometrium and myometrium were fixed in 10% neutral, buffered formalin (pH 7.4) for 24 hours. After dehydration, the material was embedded in paraffin highly purified with polymeric additives (Richard-Allan Scientific, USA) at a temperature 2 in the glandular zone and 9.2 Β± 0.6 per mm2 in the stroma. Thin nerve fibers were visualized mainly in the stroma around blood vessels associated with the ectopic endometrium ingrowth zone. A dense plexus of thin nerve fibers was also found in the subserosal layer. Furthermore, both in myometrial subserosal and submucosal layers, ramified, thin nerve fibers predominated. The number of such fibers was significantly greater than in the comparison group (17.2 Β± 1.4 vs. 11.8 Β± 0.9 per mm2, p2 ΡΡΠ΅Π·Π°, Π² ΡΡΡΠΎΠΌΠ΅ - 9,2 Β± 0,6. Π’ΠΎΠ½ΠΊΠΈΠ΅ Π½Π΅ΡΠ²Π½ΡΠ΅ Π²ΠΎΠ»ΠΎΠΊΠ½Π° Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π»ΠΈΡΡ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π² ΡΡΡΠΎΠΌΠ΅ Π²ΠΎΠΊΡΡΠ³ ΠΊΡΠΎΠ²Π΅Π½ΠΎΡΠ½ΡΡ
ΡΠΎΡΡΠ΄ΠΎΠ², ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠΈΡ
Π·ΠΎΠ½Ρ Π²ΡΠ°ΡΡΠ°Π½ΠΈΡ ΡΠΊΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΡ. ΠΡΡΡΠΎΠ΅ ΡΠΏΠ»Π΅ΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ½ΠΊΠΈΡ
Π½Π΅ΡΠ²Π½ΡΡ
Π²ΠΎΠ»ΠΎΠΊΠΎΠ½ ΡΠ°ΠΊΠΆΠ΅ Π±ΡΠ»ΠΎ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ Π² ΡΡΠ±ΡΠ΅ΡΠΎΠ·Π½ΠΎΠΌ ΡΠ»ΠΎΠ΅. ΠΡΠΈΡΠ΅ΠΌ, ΠΊΠ°ΠΊ Π² ΡΡΠ±ΡΠ΅ΡΠΎΠ·Π½ΠΎΠΌ, ΡΠ°ΠΊ ΠΈ Π² ΠΏΠΎΠ΄ΡΠ»ΠΈΠ·ΠΈΡΡΠΎΠΌ ΡΠ»ΠΎΠ΅ ΠΌΠΈΠΎΠΌΠ΅ΡΡΠΈΡ ΠΏΡΠ΅Π²Π°Π»ΠΈΡΠΎΠ²Π°Π»ΠΈ ΡΠ°Π·Π²Π΅ΡΠ²Π»Π΅Π½Π½ΡΠ΅ ΡΠΎΠ½ΠΊΠΈΠ΅ Π½Π΅ΡΠ²Π½ΡΠ΅ Π²ΠΎΠ»ΠΎΠΊΠ½Π°, ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΊΠΎΡΠΎΡΡΡ
ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎ (p2. Π‘ΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΠΈΠ½Π½Π΅ΡΠ²Π°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ° ΠΌΠ°ΡΠΊΠΈ Ρ ΠΆΠ΅Π½ΡΠΈΠ½ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ Π°Π΄Π΅Π½ΠΎΠΌΠΈΠΎΠ·ΠΎΠΌ Ρ Π±ΠΎΠ»Π΅Π²ΡΠΌ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΡΠ²Π΅ΡΠΆΠ΄Π°ΡΡ, ΡΡΠΎ ΠΈΠΌΠ΅Π½Π½ΠΎ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ ΠΈΠ½Π½Π΅ΡΠ²Π°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ Π² ΠΌΠΈΠΎΠΌΠ΅ΡΡΠΈΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²Π΅ΡΠΎΡΡΠ½ΠΎΠΉ ΠΏΡΠΈΡΠΈΠ½ΠΎΠΉ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ Π°Π΄Π΅Π½ΠΎΠΌΠΈΠΎΠ·ΠΎΠΌ. ΠΡΠ²ΠΎΠ΄Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΡΠΎΠ΄Π΅Π»Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ, ΡΡΠΎ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌ ΠΌΠ΅ΡΡΠΎΠΌ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π½Π΅ΡΠ²ΠΎΠ² Π² ΠΌΠ°ΡΠΊΠ΅ ΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΈΡΠΈΠ½ΠΎΠΉ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π³ΠΈΠΏΠ΅ΡΠ°Π»Π³Π΅Π·ΠΈΠΈ ΠΏΡΠΈ Π°Π΄Π΅Π½ΠΎΠΌΠΈΠΎΠ·Π΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΌΠΈΠΎΠΌΠ΅ΡΡΠΈΠΉ Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π°Π½ΠΎΠΌΠ°Π»ΡΠ½ΠΎ ΠΈΠ·Π±ΡΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈΠ½Π½Π΅ΡΠ²Π°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ° Π²ΠΎΠΊΡΡΠ³ ΠΎΡΠ°Π³ΠΎΠ² ΡΠΊΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΡ, Π² ΠΏΠ΅ΡΠΈΠ²Π°ΡΠΊΡΠ»ΡΡΠ½ΡΡ
ΡΠ΅Π³ΠΈΠΎΠ½Π°Ρ
ΠΈ Π² ΡΡΡΠΎΠΌΠ΅ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΡΡΠΊΠ°ΠΌΠΈ Π³Π»Π°Π΄ΠΊΠΈΡ
ΠΌΠΈΠΎΡΠΈΡΠΎΠ²
Combination therapeutic options in the treatment of the luteal phase deficiency
Luteal phase deficiency (LPD) is described as a condition of insufficient progesterone exposure to maintain a regular secretory endometrium and allow for normal embryo implantation and growth. There is evidence that both follicular and luteal phase abnormalities can result in LPD cycles. The aim of this randomized prospective noncomparative study is to evaluate the effectiveness of combination therapy in patients with LPD. This prospective study included 35 women of the reproductive age. They were diagnosed with the LPD with sonographically and laboratory-verified methods. The age of patients was 36 Β± 0.46 years. The results of the study sonographically demonstrated an increase in the diameter of the corpus luteum from 1.36 Β± 0.32 (initially) to 2.16 Β± 0.21 mm after combination therapy. In addition, there was a statistically significant increase in the level of estrogens and progesterone in the corresponding phases of the menstrual cycle. Thus, the combination therapy for patients with LPD contributes to the recovery of cyclic events in the hypothalamic-pituitary-gonadal system, which determines the restoration of the endocrine function of the ovaries and promotes adequate secretory rearrangement of the endometrium in women of reproductive age. Β© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the UR MED GRUPP (LLC)
ΠΠΈΡΠ°ΠΌΠΈΠ½ D3 (Ρ ΠΎΠ»Π΅ΠΊΠ°Π»ΡΡΠΈΡΠ΅ΡΠΎΠ») ΠΈ ΡΠ°Π·ΠΎΠ²Π°Ρ Π±ΠΎΠ»Ρ, ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½Π°Ρ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·ΠΎΠΌ ΡΠΈΡΠ½ΠΈΠΊΠΎΠ²
The article studies the relation between vitamin D concentration and the presence and intensity of pelvic pain in women suffering from ovarian endometriosis. The aim of the study is to examine the relation between vitamin D levels and intensity of pelvic pain in women with ovarian endometriosis. Study design: cohort, prospective, non-comparative study. Materials and Methods : The study included 190 women of reproductive age suffering from ovarian endometriosis (OE), aged 20 to 41 years (mean age 29.1Β±3.3 years). Visual analogue scale (VAS) was used to determine the intensity of pelvic pain.The evaluation of vitamin D level in all patients (n=190) was initially performed by determining the level of total 25 (OH) D in blood serum by the method of mass spectrometry. Study Results: The average vitamin D level in the study was 23.98Β±6.82 ng/ml. The average concentration of vitamin D in the blood of the patients with low-intensity pelvic pain was 26.7Β±5.92 ng/ml, with moderate-intensity - 23.06Β±of5.55 ng/ml, with high pain intensity - 19.26Β±6,01 ng/ml. The content of vitamin D in the blood of the patients in the control group was 28.83Β±6.15 ng/ml, which met the criteria of insufficiency. An inverse correlation between the severity of pain based on VAS and vitamin D in women with endometriosis of the main group was established in the study, it amounted to 0.502 ( p <0.001). Conclusion: Women with endometriosis of the ovaries are characterized by a decrease in the level of vitamin D to lower values than those in the control group, which meets the criteria of insufficiency of 23.98Β±6.82 ng/ml, including severe pelvic pain up to 19.26Β±6,01 ng/ml, corresponding to the state of deficiency. A moderate inverse correlation was found between the intensity of pelvic pain caused by endometriosis of the ovaries and the level of vitamin D in the blood (-0,502).Π‘ΡΠ°ΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Ρ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ ΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡΡ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ Ρ ΠΆΠ΅Π½ΡΠΈΠ½, ΡΡΡΠ°Π΄Π°ΡΡΠΈΡ
ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·ΠΎΠΌ ΡΠΈΡΠ½ΠΈΠΊΠΎΠ². Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΡΡΠΎΠ²Π½Ρ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D ΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ Ρ ΠΆΠ΅Π½ΡΠΈΠ½, ΡΡΡΠ°Π΄Π°ΡΡΠΈΡ
ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·ΠΎΠΌ ΡΠΈΡΠ½ΠΈΠΊΠΎΠ². ΠΠΈΠ·Π°ΠΉΠ½: ΠΊΠΎΠ³ΠΎΡΡΠ½ΠΎΠ΅, ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅, Π½Π΅ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ : Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠ»ΠΈ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 190 ΠΆΠ΅Π½ΡΠΈΠ½ ΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° Ρ Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ· ΡΠΈΡΠ½ΠΈΠΊΠΎΠ², Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 20 Π΄ΠΎ 41 Π³ΠΎΠ΄Π° (ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ - 29,1Β±3,3 Π³ΠΎΠ΄Π°). ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ Π²ΠΈΠ·ΡΠ°Π»ΡΠ½ΡΡ Π°Π½Π°Π»ΠΎΠ³ΠΎΠ²ΡΡ ΡΠΊΠ°Π»Ρ (ΠΠΠ¨). ΠΡΠ΅ΠΌ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠ°ΠΌ (n=190) ΠΈΡΡ
ΠΎΠ΄Π½ΠΎ ΠΎΡΠ΅Π½ΠΊΡ ΡΡΠΎΠ²Π½Ρ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΡΡΠ΅ΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ ΠΎΠ±ΡΠ΅Π³ΠΎ 25(ΠΠ)D Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΈΠΈ, Π°Π΄Π°ΠΏΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΊ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅, ΡΠΎΠ³Π»Π°ΡΠ½ΠΎ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΠΌ ΡΡΠ°Π½Π΄Π°ΡΡΠ°ΠΌ, Π½Π° ΡΠ°Π½Π΄Π΅ΠΌΠ½ΠΎΠΌ ΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠ΅ AB SCIEX QTRAP 5500. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: Π‘ΡΠ΅Π΄Π½ΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π² ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠΉ ΠΊΠΎΠ³ΠΎΡΡΠ΅ ΠΆΠ΅Π½ΡΠΈΠ½ Π² ΡΠ΅Π»ΠΎΠΌ ΡΠΎΡΡΠ°Π²ΠΈΠ» 23,98Β±6,82 Π½Π³/ΠΌΠ». Π‘ΡΠ΅Π΄Π½ΡΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π² ΠΊΡΠΎΠ²ΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΡΡ ΡΠ»Π°Π±ΠΎΠΉ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 26,7Β±5,92 Π½Π³/ΠΌΠ», ΡΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠΉ - 23,06Β±5,55 Π½Π³/ΠΌΠ», ΠΏΡΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ - 19,26Β±6,01 Π½Π³/ΠΌΠ». Π ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΡΡΠ΅Π΄Π½Π΅Π΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π² ΠΊΡΠΎΠ²ΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ 28,83Β±6,15 Π½Π³/ΠΌΠ», ΡΡΠΎ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΎΠ²Π°Π»ΠΎ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ. Π Ρ
ΠΎΠ΄Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΠΎΠ±ΡΠ°ΡΠ½Π°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡΡ Π±ΠΎΠ»Π΅Π²ΡΡ
ΠΎΡΡΡΠ΅Π½ΠΈΠΉ ΠΏΠΎ ΠΠΠ¨ ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Ρ ΠΆΠ΅Π½ΡΠΈΠ½ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ Ρ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·ΠΎΠΌ ΡΠΈΡΠ½ΠΈΠΊΠΎΠ² (-0,502; p <0,001). ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅: ΠΠ»Ρ ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·ΠΎΠΌ ΡΠΈΡΠ½ΠΈΠΊΠΎΠ² Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π΄ΠΎ Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΠΈΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ, ΡΠ΅ΠΌ Π² Π³ΡΡΠΏΠΏΠ΅ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° ΡΠΌΠ΅ΡΠ΅Π½Π½Π°Ρ ΠΎΠ±ΡΠ°ΡΠ½Π°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡΡ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΉ ΠΠ―, ΠΈ ΡΡΠΎΠ²Π½Π΅ΠΌ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π² ΠΊΡΠΎΠ²ΠΈ (-0,502)
ΠΠΈΡΠ°ΠΌΠΈΠ½ D3 (Ρ ΠΎΠ»Π΅ΠΊΠ°Π»ΡΡΠΈΡΠ΅ΡΠΎΠ») ΠΈ ΡΠ°Π·ΠΎΠ²Π°Ρ Π±ΠΎΠ»Ρ, ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½Π°Ρ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·ΠΎΠΌ ΡΠΈΡΠ½ΠΈΠΊΠΎΠ²
The article studies the relation between vitamin D concentration and the presence and intensity of pelvic pain in women suffering from ovarian endometriosis. The aim of the study is to examine the relation between vitamin D levels and intensity of pelvic pain in women with ovarian endometriosis. Study design: cohort, prospective, non-comparative study. Materials and Methods : The study included 190 women of reproductive age suffering from ovarian endometriosis (OE), aged 20 to 41 years (mean age 29.1Β±3.3 years). Visual analogue scale (VAS) was used to determine the intensity of pelvic pain.The evaluation of vitamin D level in all patients (n=190) was initially performed by determining the level of total 25 (OH) D in blood serum by the method of mass spectrometry. Study Results: The average vitamin D level in the study was 23.98Β±6.82 ng/ml. The average concentration of vitamin D in the blood of the patients with low-intensity pelvic pain was 26.7Β±5.92 ng/ml, with moderate-intensity - 23.06Β±of5.55 ng/ml, with high pain intensity - 19.26Β±6,01 ng/ml. The content of vitamin D in the blood of the patients in the control group was 28.83Β±6.15 ng/ml, which met the criteria of insufficiency. An inverse correlation between the severity of pain based on VAS and vitamin D in women with endometriosis of the main group was established in the study, it amounted to 0.502 ( p <0.001). Conclusion: Women with endometriosis of the ovaries are characterized by a decrease in the level of vitamin D to lower values than those in the control group, which meets the criteria of insufficiency of 23.98Β±6.82 ng/ml, including severe pelvic pain up to 19.26Β±6,01 ng/ml, corresponding to the state of deficiency. A moderate inverse correlation was found between the intensity of pelvic pain caused by endometriosis of the ovaries and the level of vitamin D in the blood (-0,502).Π‘ΡΠ°ΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Ρ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ ΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡΡ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ Ρ ΠΆΠ΅Π½ΡΠΈΠ½, ΡΡΡΠ°Π΄Π°ΡΡΠΈΡ
ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·ΠΎΠΌ ΡΠΈΡΠ½ΠΈΠΊΠΎΠ². Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΡΡΠΎΠ²Π½Ρ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D ΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ Ρ ΠΆΠ΅Π½ΡΠΈΠ½, ΡΡΡΠ°Π΄Π°ΡΡΠΈΡ
ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·ΠΎΠΌ ΡΠΈΡΠ½ΠΈΠΊΠΎΠ². ΠΠΈΠ·Π°ΠΉΠ½: ΠΊΠΎΠ³ΠΎΡΡΠ½ΠΎΠ΅, ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅, Π½Π΅ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ : Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠ»ΠΈ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 190 ΠΆΠ΅Π½ΡΠΈΠ½ ΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° Ρ Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ· ΡΠΈΡΠ½ΠΈΠΊΠΎΠ², Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 20 Π΄ΠΎ 41 Π³ΠΎΠ΄Π° (ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ - 29,1Β±3,3 Π³ΠΎΠ΄Π°). ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ Π²ΠΈΠ·ΡΠ°Π»ΡΠ½ΡΡ Π°Π½Π°Π»ΠΎΠ³ΠΎΠ²ΡΡ ΡΠΊΠ°Π»Ρ (ΠΠΠ¨). ΠΡΠ΅ΠΌ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠ°ΠΌ (n=190) ΠΈΡΡ
ΠΎΠ΄Π½ΠΎ ΠΎΡΠ΅Π½ΠΊΡ ΡΡΠΎΠ²Π½Ρ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΡΡΠ΅ΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ ΠΎΠ±ΡΠ΅Π³ΠΎ 25(ΠΠ)D Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΈΠΈ, Π°Π΄Π°ΠΏΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΊ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅, ΡΠΎΠ³Π»Π°ΡΠ½ΠΎ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΠΌ ΡΡΠ°Π½Π΄Π°ΡΡΠ°ΠΌ, Π½Π° ΡΠ°Π½Π΄Π΅ΠΌΠ½ΠΎΠΌ ΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠ΅ AB SCIEX QTRAP 5500. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: Π‘ΡΠ΅Π΄Π½ΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π² ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠΉ ΠΊΠΎΠ³ΠΎΡΡΠ΅ ΠΆΠ΅Π½ΡΠΈΠ½ Π² ΡΠ΅Π»ΠΎΠΌ ΡΠΎΡΡΠ°Π²ΠΈΠ» 23,98Β±6,82 Π½Π³/ΠΌΠ». Π‘ΡΠ΅Π΄Π½ΡΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π² ΠΊΡΠΎΠ²ΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΡΡ ΡΠ»Π°Π±ΠΎΠΉ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 26,7Β±5,92 Π½Π³/ΠΌΠ», ΡΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠΉ - 23,06Β±5,55 Π½Π³/ΠΌΠ», ΠΏΡΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ - 19,26Β±6,01 Π½Π³/ΠΌΠ». Π ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΡΡΠ΅Π΄Π½Π΅Π΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π² ΠΊΡΠΎΠ²ΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ 28,83Β±6,15 Π½Π³/ΠΌΠ», ΡΡΠΎ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΎΠ²Π°Π»ΠΎ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ. Π Ρ
ΠΎΠ΄Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΠΎΠ±ΡΠ°ΡΠ½Π°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡΡ Π±ΠΎΠ»Π΅Π²ΡΡ
ΠΎΡΡΡΠ΅Π½ΠΈΠΉ ΠΏΠΎ ΠΠΠ¨ ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Ρ ΠΆΠ΅Π½ΡΠΈΠ½ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ Ρ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·ΠΎΠΌ ΡΠΈΡΠ½ΠΈΠΊΠΎΠ² (-0,502; p <0,001). ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅: ΠΠ»Ρ ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·ΠΎΠΌ ΡΠΈΡΠ½ΠΈΠΊΠΎΠ² Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π΄ΠΎ Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΠΈΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ, ΡΠ΅ΠΌ Π² Π³ΡΡΠΏΠΏΠ΅ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° ΡΠΌΠ΅ΡΠ΅Π½Π½Π°Ρ ΠΎΠ±ΡΠ°ΡΠ½Π°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡΡ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΉ ΠΠ―, ΠΈ ΡΡΠΎΠ²Π½Π΅ΠΌ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π² ΠΊΡΠΎΠ²ΠΈ (-0,502)