Nonstationary Stochastic Resonance in a Single Neuron-Like System

Stochastic resonance holds much promise for the detection of weak signals in the presence of relatively loud noise. Following the discovery of nondynamical and of aperiodic stochastic resonance, it was recently shown that the phenomenon can manifest itself even in the presence of nonstationary signals. This was found in a composite system of differentiated trigger mechanisms mounted in parallel, which suggests that it could be realized in some elementary neural networks or nonlinear electronic circuits. Here, we find that even an individual trigger system may be able to detect weak nonstationary signals using stochastic resonance. The very simple modification to the trigger mechanism that makes this possible is reminiscent of some aspects of actual neuron physics. Stochastic resonance may thus become relevant to more types of biological or electronic systems injected with an ever broader class of realistic signals.Comment: Plain Latex, 7 figure

Comparison of Microstructures and Mechanical Properties for Solid Cobalt-Base Alloy Components and Biomedical Implant Prototypes Fabricated by Electron Beam Melting

The microstructures and mechanical behavior of simple, as-fabricated, solid geometries (with a density of 8.4 g/cm3), as-fabricated and fabricated and annealed femoral (knee) prototypes all produced by additive manufacturing (AM) using electron beam melting (EBM) of Co-26Cr-6Mo-0.2C powder are examined and compared in this study. Microstructures and microstructural issues are examined by optical metallography, SEM, TEM, EDS, and XRD while mechanical properties included selective specimen tensile testing and Vickers microindentation (HV) and Rockwell C-scale (HRC) hardness measurements. Orthogonal (X-Y) melt scanning of the electron beam during AM produced unique, orthogonal and related Cr23C6 carbide (precipitate) cellular arrays with dimensions of ~2μm in the build plane perpendicular to the build direction, while connected carbide columns were formed in the vertical plane, parallel to the build direction.Mechanical Engineerin

Effect of Build Parameters and Build Geometries on Residual Microstructures and Mechanical Properties of Ti-6Al-4V Components Built by Electron Beam Melting (EBM)

In this study, involving additive manufacturing (AM) using electron beam melting (EBM), we have examined build defects which result from beam tripping, porosities (including unmelted or unsintered zones) due to excursions from optimal build parameters (especially variations in melt scan beam current and scan speed), and gas bubbles trapped in atomized Ti-6Al-4V starting powder as well as recycled powder, and retained in the build. At optimized build conditions we have also examined microstructure-mechanical property (hardness, tensile strength, and elongation) variations for multiple rake building and multiple melt scans using optical metallography and scanning and transmission electron microscopy (SEM and TEM). These build variances cause cooling rate variances which promote α-phase growth and variations in dislocation density, as well as α-to-α' (martensite) phase changes, all of which produce some degree of mechanical property variations. These features (especially α-to-α' phase changes) are notable on comparing solid builds in comparison with a variety of mesh arrays where strut dimension and build-element complexities alter the cooling rates in a significant way. We illustrate these microstructure variations with corresponding variations in microindentation hardness measurements made directly on fine mesh (strut) structures. Finally, we have examined Ti-6Al-4V powder chemistries and solid build chemistries which for single-pass melt scans at optimized build conditions are shown to be relatively constant up to 40 cycles of powder reuse with the exception of Al content which was reduced by 10 to 15% in solid builds at optimized conditions. However, Al loss in solid builds approached 25% for multiple (2 and 3) melt scans, while no changes in Ar gas-bubble density were observed with changes in α-phase (grain) width which increased from 3 µm for a single melt scan to 4.5 and 6 µm for 2 and 3 melt scans, respectively. Corresponding Rockwell C-scale (HRC) hardness varied from 37, 36, and 35, respectively; with ultimate tensile strengths exceeding 1.2 GPa at elongations of 12% or higher for this melt scan sequence.Mechanical Engineerin

kt Effects in Direct-Photon Production

We discuss the phenomenology of initial-state parton-kt broadening in direct-photon production and related processes in hadron collisions. After a brief summary of the theoretical basis for a Gaussian-smearing approach, we present a systematic study of recent results on fixed-target and collider direct-photon production, using complementary data on diphoton and pion production to provide empirical guidance on the required amount of kt broadening. This approach provides a consistent description of the observed pattern of deviation of next-to-leading order QCD calculations relative to the direct-photon data, and accounts for the shape and normalization difference between fixed-order perturbative calculations and the data. We also discuss the uncertainties in this phenomenological approach, the implications of these results on the extraction of the gluon distribution of the nucleon, and the comparison of our findings to recent related work.Comment: LaTeX, uses revtex and epsf, 37 pages, 15 figure

Factorization Breaking in Dijet Photoproduction with a Leading Neutron

The production of dijets with a leading neutron in ep-interactions at HERA is calculated in leading order and next-to-leading order of perturbative QCD using a pion-exchange model. Differential cross sections for deep-inelastic scattering (DIS) and photoproduction are presented as a function of several kinematic variables. By comparing the theoretical predictions for DIS dijets to recent H1 data, the pion flux factor together with the parton distribution functions of the pion is determined. The dijet cross sections in photoproduction show factorization breaking if compared to the H1 photoproduction data. The suppression factor is S = 0.48 (0.64) for resolved (global) suppression.Comment: 16 pages, 5 figure

Temporal changes in tau phosphorylation and related kinase and phosphatases following two models of traumatic brain injury

Published: November 09, 2018A history of traumatic brain injury (TBI) is linked to later neurodegeneration, with a key feature accumulation of hyperphosphorylated tau. Tau is a microtubule stability protein that undergoes frequent cycles of phosphorylation and dephosphorylation due to kinases and phosphatase activity. Hyperphosphorylation of tau destabilizes microtubules interrupting axonal transport, as well as promotes aggregation disturbing synaptic dysfunction. Aberrant phosphorylation of tau post-injury is thought to be a key player in later neurodegeneration. However, it is not known whether type of TBI- a single severe injury compared to repeated mild injuries- affects the time course of tau accumulation or the pattern of changes in kinases and phosphatases that facilitate this phosphorylation. To investigate, male Sprague Dawley rats were subjected to either a single moderate/severe or 3 mild TBIs spaced 5 days apart (rmTBI) utlising the Marmarou impact-acceleration model. Levels of cortical ptau (AT180, pSer422, oligomeric tau), pGSK3β, pCDK5, pERK1/2, pAkt and PP2Ac were evaluated at 24h, 7 days, 1 month and 3 months post-injury, with changes in tau phosphorylation confirmed via immunohistochemistry. A similar time course of AT180 tau phosphorylation was seen irrespective of the nature of the initiating insult, with a spike at 24h post-injury return to baseline and then increasing chronically at 3 months post-injury. In line with this, levels of PP2Ac were decreased at 24h and 3 months post-injury, indicating a potential loss of phosphatase activity. Interestingly, minimal changes were seen in the kinases examined, with a spike in phosphorylation of GSK3β, at the inhibitory Ser site, at 24h and 3 months following rmTBI, but not single moderate severe TBI, suggesting a possible protective effect only post-rmTBI. This study highlights that changes in levels of phosphorylated tau are similar, regardless of the initiating injury, and highlights the need to further understand the driving mechanisms behind this phenomenon.Lyndsey Collins-Praino, Daniel Gutschmidt, Jessica Sharkey, Alina Arulsamy, and Frances Corriga

Influencia del agua en la esterificación enzimática de ketoprofeno racémico con etanol sin co-solvente agregado

Las lipasas son las enzimas más comúnmente usadas para producir dexketoprofeno mediante resolución cinética. Este isómero es farmacológicamente activo, por lo que su obtención de forma pura disminuiría los efectos adversos del AINE

Single-Inclusive Jet Production in Polarized pp Collisions at O(alpha_s^3)

We present a next-to-leading order QCD calculation for single-inclusive high-p_T jet production in longitudinally polarized pp collisions within the ``small-cone'' approximation. The fully analytical expressions obtained for the underlying partonic hard-scattering cross sections greatly facilitate the analysis of upcoming BNL-RHIC data on the double-spin asymmetry A_{LL}^{jet} for this process in terms of the unknown polarization of gluons in the nucleon. We simultaneously rederive the corresponding QCD corrections to unpolarized scattering and confirm the results existing in the literature. We also numerically compare to results obtained with Monte-Carlo methods and assess the range of validity of the ``small-cone'' approximation for the kinematics relevant at BNL-RHIC.Comment: 23 pages, 8 eps-figure

Next-to-leading order QCD corrections to A_TT for prompt photon production

We present a next-to-leading order QCD calculation of the cross section for isolated large-p_T prompt photon production in collisions of transversely polarized protons. We devise a simple method of dealing with the phase space integrals in dimensional regularization in the presence of the cos(2 phi) azimuthal-angular dependence occurring for transverse polarization. Our results allow to calculate the double-spin asymmetry A_TT for this process at next-to-leading order accuracy, which may be used at BNL-RHIC to measure the transversity parton distributions of the proton.Comment: 19 pages, LaTeX, 2 figures as eps file