Aegle marmelos (L.) Correa as a potential candidate for treatment of diabetes mellitus: A review

Introduction: Aegle marmelos (L.) Correa is an important medicinal plant, commonly known as Bael which is belonged to family Rutaceae. It is widely distributed in Asian countries. According to the literature, various chemical constituents and pharmacological effects have been reported for this plant. In Ayurvedic and traditional medicinal systems, different parts of A. marmelos are used for diabetes mellitus. In the present review, an attempt was made to summarize the in vivo and in vitro studies and clinical trials conducted to evaluate or validate the anti-diabetic activity and toxicity of A. marmelos. Methods: PubMed, Science Direct, Google Scholar, Directory of open access journals (DOAJ), EMBASE, and Web of Science were searched using the keywords Aegle marmelos and diabetes. Results: Anti-diabetic potential, clinical applications of different parts of A. marmelos and possible toxic effects have been revealed in A. marmelos extract. Conclusion: Aegle marmelos can be used as a potential candidate for diabetes mellitus

Ethnomedicinal, phytochemical and pharmacological properties of Pogostemon heyneanus Benth: A review

162-173A renewed interest in using nature-originated medicines can be seen throughout the world due to their benefits when compared to synthetic or semi-synthetic drugs in the aspect of increasing the quality of life of human beings. Pogostemon heyneanus Benth is a prominent and well-known medicinal plant in Asian countries that is recommended with high value in traditional medicinal practices, Ayurvedic treatments and folkloric use. It is also known as 'Indian patchouli' and 'Java patchouli'. P. heyneanus is pharmacologically and economically important due to its essential oil and is used in perfumery industries as well. The consistency of the presence of a wide range of phytochemical constituents such as phenolic compounds, terpenes, steroids, flavonoids, saponins, and tannins enables activities like cytotoxic and anticancer, antimicrobial, antioxidant, gastroprotective, etc. Essential oil of P. heyneanus is comprised of α–pinene, β-pinene, limonene, β-pachoulin, seychellene, β-caryophyllene, α–guaiene, nerolidol and patchouli alcohol. Moreover, P. heyneanus is a unique cause having acetophenone as its main component which was not reported in the essential oils of other Pogostemon species. The scope of the present review was to gather scientific information on P. heyneanus in terms of habitat and distribution, traditional uses and ethnopharmacology, phytochemistry, and medicinal activities (cytotoxic and anticancer, antimicrobial, antioxidant and gastroprotective), which were published before 31st July 2022

The gastroprotective effect of ethyl acetate fraction of hot water extract of Trichosanthes cucumerina Linn and its underlying mechanisms

Abstract Background Antacids, anticholinergic drugs, histamine H2- receptor antagonists and irreversible proton pump inhibitors have been used for the treatment of gastric ulcers. However, prolonged use of these drugs may lead to series of adverse effects such as diarrhea, headache, rash, hypertension, muscular and joint pain. Therefore, there is an urgent need of more effective and safer treatments with fewer side effects. The aim of the present study was to scientifically evaluate the gastroprotective activity of fractions of the hot water extract of Trichosanthes cucumerina Linn (Family: Cucurbitaceae) aerial parts with a view to identifying the fraction with the best gastroprotective activity and the possible mechanism/s by which this fraction exert gastroprotection. Methods Gastroprotective activity of hexane fraction (HF), ethyl acetate fraction (EF), butanol fraction (BF) and aqueous fraction (AF) were evaluated by the assessment of ability to reduce the ulcer index in ethanol-induced rat model and the mode of action by which the most active fraction mediating gastroprotection. Results EF showed the maximum gastroprotection effect followed by BF and AF. EF (75 mg/kg) exhibited significantly higher gastroprotection compared to the reference drugs. Further investigations with two lower doses of EF confirmed that EF can mediated a significant and dose dependent gastroprotection. The rats treated with the EF showed significant reduction in free acidity (45%), total acidity (by 48%) in the gastric juice, increased the amount of mucus produced by the rat gastro mucosa and potent antihistamine activity (by 25.6%). EF was also rich in phenolic compounds and flavonoids. Conclusion Gastroprotective mechanism of EF is possibly involves inhibition of acidity, elevation in mucus content, inhibition of histamine and antioxidant mechanisms