321 research outputs found
Voltage Grid Supporting by Using Variable Structure Adaptive Virtual Impedance for LCL-Voltage Source Converter DG Converters
Caracterização das águas subterrâneas usadas para irrigação na área produtora de melão da Chapada do Apodi
Seleção de descritores para caracterização de germoplasma de açaizeiro para produção de frutos
Floristic composition and structure of an upper montane cloud forest in the Serra da Mantiqueira Mountain Range of Brazil
Effects of cholinergic stimulation with pyridostigmine bromide on chronic chagasic cardiomyopathic mice
The aim of the present study was to assess the effects of an anticholinesterase agent, pyridostigmine bromide (Pyrido), on experimental chronic Chagas heart disease in mice. To this end, male C57BL/6J mice noninfected (control:Con) or chronically infected (5 months) with Trypanosoma cruzi (chagasic:Chg) were treated or not (NT) with Pyrido for one month. At the end of this period, electrocardiogram (ECG); cardiac autonomic function; heart histopathology; serum cytokines; and the presence of blood and tissue parasites by means of immunohistochemistry and PCR were assessed. In NT-Chg mice, significant changes in the electrocardiographic, autonomic, and cardiac histopathological profiles were observed confirming a chronic inflammatory response. Treatment with Pyrido in Chagasic mice caused a significant reduction of myocardial inflammatory infiltration, fibrosis, and hypertrophy, which was accompanied by a decrease in serum levels of IFN\u3b3 with no change in IL-10 levels, suggesting a shift of immune response toward an anti-inflammatory profile. Lower nondifferent numbers of parasite DNA copies were observed in both treated and nontreated chagasic mice. In conclusion, our findings confirm the marked neuroimmunomodulatory role played by the parasympathetic autonomic nervous system in the evolution of the inflammatory-immune response to T. cruzi during experimental chronic Chagas heart disease in mice
BRS Carla - alternativa de soja com ciclo médio para os sistemas de produção de grãos nos Cerrados
Desempenho de cutias (Dasyprocta prymnolopha) criadas em cativeiro do nascimento até o desmame em Teresina, Piauí
Characteristics of forage and feeding behavior of Nellore heifers fed hydrolyzed sugarcane
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