Patologie cutanee da tessuti

Clothes and clothing accessories are one of the most frequent causes of contact dermatitis. There are many data showing that the frequency of textile-dye allergy is increasing, however the exact incidence of clothing dermatitis is unknown (from 1% to 15%). Recent studies from Germany, Austria and North America demonstrate that contact dermatitis produced by allergic or irritant reactions to clothing is more frequent than previously thought. In the second half of nineties in Italy the GIRDCA (Gruppo Italiano Ricerca Dermatiti da Contatto e Ambientali) extimed that the incidence of clothing dermatitis in Italy was 10% of all extraprofessional allergic contact dermatitis. In thefuture, for the increasing shin sensitisation of European population and the elevated commercialization of non controlled products from other countries, contact dermatitis will be a public health problem. This context requests some new prevention strategies

Infantile seborrhoeic dermatitis: a disappearing disease

Baboon syndrome is a systemically induced allergic contact dermatitis, usually associated in children with a previous sensitization to mercury and triggered by inhalation of mercury vapor from a broken thermometer. Here are reported two cases in children without a previous history of localized dermatitis, but with proven sensitization to mercury

Skin Manifestations Induced by TNF-Alpha Inhibitors in Juvenile Idiopathic Arthritis

The tumor necrosis factor alpha (TNF\u3b1) inhibitors have been used with good clinical results in the treatment of juvenile idiopathic arthritis (JIA). Anti TNF\u3b1 therapy is generally well tolerated. Besides the site injection reactions, other various cutaneous manifestations have been encountered as adverse events. Here, we report four young patients receiving treatment with anti-TNF\u3b1 (infliximab, adalimumab, and etanercept) for JIA developing different skin manifestations more than 1 year after the initiation of therapy. They underwent a dermatological exam. All four patients were ACR-Ped 30 responders to anti-TNF drugs. The first patient developed cutaneous vasculitis, the second one had lichen planus manifestations, while the third and the fourth developed psoriatic palmoplantar pustulosis accompanied by plaque-type psoriasis localized to the scalp. None of the patients had a personal or family history of dermatological diseases. In the first two patients, skin lesions healed with topical treatment after the discontinuation of anti-TNF agent, while psoriatic lesions did not resolve despite discontinuation of the drug and dermatological treatment. TNF inhibition can be both anti-inflammatory and pro-inflammatory. Cutaneous manifestations could be considered as a paradoxical adverse event of the anti-TNF-alpha treatment not only in rheumatoid arthritis but also in juvenile idiopathic arthritis

Association of palmoplantar keratoderma, cutaneous squamous cell carcinoma, dental anomalies, and hypogenitalism in four siblings with 46,XX karyotype : a new syndrome

The association of palmoplantar keratoderma (PPK) with the development of cutaneous squamous cell carcinomas (SCCs), dental anomalies, severe hypogenitalism with hypospadias, abnormal development of gonads with ambiguous external genitalia, gynecomastia, altered plasma sex hormones levels, and hypertriglyceridemia has not, to our knowledge, been reported previously. We describe it in 4 brothers with 46,XX karyotype, whereas the 5 sisters of their consanguineous parents were unaffected. This family may represent a new syndrome. The PPK was of the classical nonepidermolytic histologic type. The proband also had a laryngeal carcinoma diagnosed in his early forties and nodular testicular hyperplasia of Leydig cells