The features of lipid metabolism in patients with chronic low activity rheumatic heart disease in combination with coronary heart disease

Представлены данные о существенных признаках дисбаланса липидного обмена у больных с хронической ревматической болезнью сердца низкой степени активности в сочетании с ишемической болезнью сердца. У этих больных отмечены изменения липидного обмена (по сравнению с больными только с ревматизмом или только с ишемической болезнью сердца), которые активировали риск атеросклеротических изменений. Выявлено достоверное повышение триглицеридов, липопротеидов низкой плотности и липопротеидов очень низкой плотности.The data on the characteristics of lipid metabolism in patients with chronic low activity rheumatic heart disease in combination with coronary artery disease and the dependence of lipid metabolism changes in these patients are presented. Lipid metabolism in rheumatism in combination with coronary heart disease had significant signs of imbalance. In patients with rheumatic disease and coronary heart disease compared to patients with rheumatism only or with coronary heart disease only changes in lipid metabolism activating the risk of atherosclerotic changes were noted. In particular a significant increase in triglycerides, low density lipoproteins and very low density lipoproteins was registered

New Biocides Based on <i>N</i>⁴-Alkylcytidines: Effects on Microorganisms and Application for the Protection of Cultural Heritage Objects of Painting

The rapid increase in the antibiotic resistance of microorganisms, capable of causing diseases in humans as destroying cultural heritage sites, is a great challenge for modern science. In this regard, it is necessary to develop fundamentally novel and highly active compounds. In this study, a series of N4-alkylcytidines, including 5- and 6-methylcytidine derivatives, with extended alkyl substituents, were obtained in order to develop a new generation of antibacterial and antifungal biocides based on nucleoside derivatives. It has been shown that N4-alkyl 5- or 6-methylcytidines effectively inhibit the growth of molds, isolated from the paintings in the halls of the Ancient Russian Paintings of the State Tretyakov Gallery, Russia, Moscow. The novel compounds showed activity similar to antiseptics commonly used to protect works of art, such as benzalkonium chloride, to which a number of microorganisms have acquired resistance. It was also shown that the activity of N4-alkylcytidines is comparable to that of some antibiotics used in medicine to fight Gram-positive bacteria, including resistant strains of Staphylococcus aureus and Mycobacterium smegmatis. N4-dodecyl-5- and 6-methylcytidines turned out to be the best. This compound seems promising for expanding the palette of antiseptics used in painting, since quite often the destruction of painting materials is caused by joint fungi and bacteria infection