6 research outputs found
The features of lipid metabolism in patients with chronic low activity rheumatic heart disease in combination with coronary heart disease
ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°Ρ
Π΄ΠΈΡΠ±Π°Π»Π°Π½ΡΠ° Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ ΡΠ΅ΡΠ΄ΡΠ° Π½ΠΈΠ·ΠΊΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ ΡΠ΅ΡΠ΄ΡΠ°. Π£ ΡΡΠΈΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΎΡΠΌΠ΅ΡΠ΅Π½Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° (ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π±ΠΎΠ»ΡΠ½ΡΠΌΠΈ ΡΠΎΠ»ΡΠΊΠΎ Ρ ΡΠ΅Π²ΠΌΠ°ΡΠΈΠ·ΠΌΠΎΠΌ ΠΈΠ»ΠΈ ΡΠΎΠ»ΡΠΊΠΎ Ρ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ ΡΠ΅ΡΠ΄ΡΠ°), ΠΊΠΎΡΠΎΡΡΠ΅ Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π»ΠΈ ΡΠΈΡΠΊ Π°ΡΠ΅ΡΠΎΡΠΊΠ»Π΅ΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ. ΠΡΡΠ²Π»Π΅Π½ΠΎ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΈΠ³Π»ΠΈΡΠ΅ΡΠΈΠ΄ΠΎΠ², Π»ΠΈΠΏΠΎΠΏΡΠΎΡΠ΅ΠΈΠ΄ΠΎΠ² Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ ΠΈ Π»ΠΈΠΏΠΎΠΏΡΠΎΡΠ΅ΠΈΠ΄ΠΎΠ² ΠΎΡΠ΅Π½Ρ Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ.The data on the characteristics of lipid metabolism in patients with chronic low activity rheumatic heart disease in combination with coronary artery disease and the dependence of lipid metabolism changes in these patients are presented. Lipid metabolism in rheumatism in combination with coronary heart disease had significant signs of imbalance. In patients with rheumatic disease and coronary heart disease compared to patients with rheumatism only or with coronary heart disease only changes in lipid metabolism activating the risk of atherosclerotic changes were noted. In particular a significant increase in triglycerides, low density lipoproteins and very low density lipoproteins was registered
Excitation of Kr+ and Xe+ ions in negative glow discharges in mixtures of neon with krypton and xenon
Model-potential method for the calculation of atom-rare-gas interactions: application to the Na-Ne system
New Biocides Based on <i>N</i><sup>4</sup>-Alkylcytidines: Effects on Microorganisms and Application for the Protection of Cultural Heritage Objects of Painting
The rapid increase in the antibiotic resistance of microorganisms, capable of causing diseases in humans as destroying cultural heritage sites, is a great challenge for modern science. In this regard, it is necessary to develop fundamentally novel and highly active compounds. In this study, a series of N4-alkylcytidines, including 5- and 6-methylcytidine derivatives, with extended alkyl substituents, were obtained in order to develop a new generation of antibacterial and antifungal biocides based on nucleoside derivatives. It has been shown that N4-alkyl 5- or 6-methylcytidines effectively inhibit the growth of molds, isolated from the paintings in the halls of the Ancient Russian Paintings of the State Tretyakov Gallery, Russia, Moscow. The novel compounds showed activity similar to antiseptics commonly used to protect works of art, such as benzalkonium chloride, to which a number of microorganisms have acquired resistance. It was also shown that the activity of N4-alkylcytidines is comparable to that of some antibiotics used in medicine to fight Gram-positive bacteria, including resistant strains of Staphylococcus aureus and Mycobacterium smegmatis. N4-dodecyl-5- and 6-methylcytidines turned out to be the best. This compound seems promising for expanding the palette of antiseptics used in painting, since quite often the destruction of painting materials is caused by joint fungi and bacteria infection