229 research outputs found
Iron Catalyzed Double Bond Isomerization:Evidence for an FeI/FeIII Catalytic Cycle
Iron‐catalyzed isomerization of alkenes is reported using an iron(II) β‐diketiminate pre‐catalyst. The reaction proceeds with a catalytic amount of a hydride source, such as pinacol borane (HBpin) or ammonia borane (H3N⋅BH3). Reactivity with both allyl arenes and aliphatic alkenes has been studied. The catalytic mechanism was investigated by a variety of means, including deuteration studies, Density Functional Theory (DFT) and Electron Paramagnetic Resonance (EPR) spectroscopy. The data obtained support a pre‐catalyst activation step that gives access to an η2‐coordinated alkene FeI complex, followed by oxidative addition of the alkene to give an FeIII intermediate, which then undergoes reductive elimination to allow release of the isomerization product
Phosphirenium Ions as Masked Phosphenium Catalysts:Mechanistic Evaluation and Application in Synthesis
The utilization of phosphirenium ions is presented; optimized and broadened three-membered ring construction is described together with the use of these ions as efficient pre-catalysts for metal-free carbonyl reduction with silanes. Full characterization of the phosphirenium ions is presented, and initial experimental and computational mechanistic studies indicate that these act as a "masked phosphenium"source that is accessed via ring opening. Catalysis proceeds via associative transfer of {Ph2P+} to a carbonyl nucleophile, Hâ'SiR3 bond addition over the C=O group, and associative displacement of the product by a further equivalent of the carbonyl substrate, which completes the catalytic cycle. A competing off-cycle process leading to vinyl phosphine formation is detailed for the hydrosilylation of benzophenone for which an inverse order in [silane] is observed. Experimentally, the formation of side products, including off-cycle vinyl phosphine, is favored by electrondonating substituents on the phosphirenium cation, while catalytic hydrosilylation is promoted by electron-withdrawing substituents. These observations are rationalized in parallel computational studies.</p
Phosphirenium ions as masked phosphenium catalysts : mechanistic evaluation and application in synthesis
The EPSRC is thanked for funding. S.E.N. thanks Heriot Watt University for the award of a James Watt scholarship.The utilization of phosphirenium ions is presented; optimized and broadened three-membered ring construction is described together with the use of these ions as efficient pre-catalysts for metal-free carbonyl reduction with silanes. Full characterization of the phosphirenium ions is presented, and initial experimental and computational mechanistic studies indicate that these act as a "masked phosphenium"source that is accessed via ring opening. Catalysis proceeds via associative transfer of {Ph2P+} to a carbonyl nucleophile, Hâ'SiR3 bond addition over the C=O group, and associative displacement of the product by a further equivalent of the carbonyl substrate, which completes the catalytic cycle. A competing off-cycle process leading to vinyl phosphine formation is detailed for the hydrosilylation of benzophenone for which an inverse order in [silane] is observed. Experimentally, the formation of side products, including off-cycle vinyl phosphine, is favored by electrondonating substituents on the phosphirenium cation, while catalytic hydrosilylation is promoted by electron-withdrawing substituents. These observations are rationalized in parallel computational studies.Peer reviewe
Markovnikov versus anti-Markovnikov hydrophosphination: Divergent reactivity using an iron(II) β-diketiminate pre-catalyst
The ability to tune between different regioselectivities using a common pre-catalyst is an unusual yet highly desirable process. Here, we report the use of an iron(II) pre-catalyst that can be used to synthesize vinyl phosphines in a Markovnikov-selective manner in benzene, whereas a simple change to dichloromethane as the reaction solvent leads to the Z-selective anti-Markovnikov product. Preliminary mechanistic studies are reported that suggest Markovnikov selectivity is a radical-mediated process, whereas the anti-Markovnikov selectivity is not radical in nature but is due to a change in oxidation state
Titanium pyridonates for the homo- and copolymerization of <i>rac</i>-lactide and ε-caprolactone
A series of titanium pyridonate complexes have been synthesized under very mild reaction conditions from a common precursor, Ti(NMe2)4. These complexes have been explored as initiators for the ring-opening polymerization of rac-lactide and ε-caprolactone and have proven to be competitive with leading titanium initiators.</p
3-D Photoionization Structure and Distances of Planetary Nebulae II. Menzel 1
We present the results of a spatio-kinematic study of the planetary nebula
Menzel 1 using spectro-photometric mapping and a 3-D photoionization code. We
create several 2-D emission line images from our long-slit spectra, and use
these to derive the line fluxes for 15 lines, the Halpha/Hbeta extinction map,
and the [SII] line ratio density map of the nebula. We use our photoionization
code constrained by these data to derive the three-dimensional nebular
structure and ionizing star parameters of Menzel 1 by simultaneously fitting
the integrated line intensities, the density map, and the observed morphologies
in several lines, as well as the velocity structure. Using theoretical
evolutionary tracks of intermediate and low mass stars, we derive a mass for
the central star of 0.63+-0.05 Msolar. We also derive a distance of 1050+_150
pc to Menzel 1.Comment: To be published in ApJ of 10th February 2005. 12 figure
Facile, catalytic dehydrocoupling of phosphines using β-diketiminate iron(II) complexes
Catalytic dehydrocoupling of primary and secondary phosphines has been achieved for the first time using an iron pre-catalyst. The reaction proceeds under mild reaction conditions and is successful with a range of diarylphosphines. A proton acceptor is not needed for the transformation to take place, but addition of 1-hexene does allow for turnover at 50 °C. The catalytic system developed also facilitates the dehydrocoupling of phenylphosphane and dicyclohexylphosphane. A change in solvent switches off dehydrocoupling to allow hydrophosphination of alkenes
Iron catalysed Negishi cross-coupling using simple ethyl-monophosphines
Reported is a rare example of the use of monophosphines in iron catalysed Negishi cross-coupling. Substrate scope in terms of alkyl bromide and diaryl zinc reagent is explored.</p
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