71 research outputs found
Решение проблемы повышенной чувствительности дентина: механизмы реминерализации при курсовом использовании зубной пасты с фторидом олова
The purpose of the study was clinical and laboratory analysis of the remineralizing properties and clinical efficacy of the course application of the Sensodyne Rapid Relief therapeutic and prophylactic toothpaste for sensitive teeth with tin fluoride. The study involved 50 overwise healthy patients aged from 18 to 25 years diagnosed with a localized form of hyperesthesia of hard dental tissues and no signs of acute inflammation of periodontal tissues. After 7 days of clinical observation and daily use of the toothpaste the hygienic condition of the oral cavity in all patients improved: oral hygiene index was 1.02±0.2 units; gum inflammation index (PMA) - 8.0±1.5%; the absence of hyperesthesia was diagnosed (1 point, p≤0.05). Examination of patients after 14 and 28 days confirmed the absence of pain in 100%, the organoleptic properties of the toothpaste under investigation were also highly appreciated by the participants. A laboratory study showed that patients have an increase in the pH value of mixed saliva and a decrease in its buffer capacity by 13.4±2.25%, which contributes to a more effective remineralizing effect of calcium ions by calcium-binding proteins of mixed saliva. The concentration of fluoride ions in the saliva of patients of both groups increased by average rate of 34±0.5% per week. The combination of tin and fluoride is more effective than fluoride alone. The presence of tin ions causes a higher ability of fluorides to bind with calcium ions on the surface of the dentin and dentinal tubules, inhibits the process of demineralization, enhances the additive interaction of the ions forming the acid-resistant layer on the surface of the dentin and dentinal tubules, leading to a decrease in hyperesthesia of the teeth.Цель исследования - клинико-лабораторный анализ реминерализующих свойств и клинической эффективности курсового применения лечебно-профилактической зубной пасты Sensodyne Мгновенный Эффект для чувствительных зубов с фторидом олова. Обследованы 50 практически здоровых пациентов в возрасте от 18 до 25 лет, у которых диагностированы локализованная форма гиперестезии твердых тканей зубов и отсутствие признаков острого воспаления тканей пародонта. По истечении 7 дней клинического наблюдения и ежедневного использования данной зубной пасты гигиеническое состояние полости рта у всех пациентов улучшилось - индекс гигиены составил 1,02±0,2 единицы; индекс воспаления десны (РМА) - 8,0±1,5%; диагностировано отсутствие гиперестезии (1 балл, р≤0,05). Обследование пациентов через 14 и 28 дней подтвердило отсутствие боли в 100% случаев, органолептические свойства исследуемой зубной пасты также высоко оценены участниками. Проведенное лабораторное исследование показало, что у пациентов наблюдается увеличение значения рН смешанной слюны и происходит снижение ее буферной емкости на 13,4±2,25%, что способствует более эффективной реминерализирующей отдаче ионов кальция кальцийсвязывающими белками смешанной слюны. Концентрация ионов фтора в слюне пациентов обеих групп за 1 нед увеличивается в среднем на 34±0,5%. Сочетание олова и фторида более эффективно, чем применение только фторида. Присутствие ионов олова обусловливает более высокую способность фторидов к связыванию с ионами кальция на поверхности дентина и дентинных канальцев, ингибирует процесс деминерализации, усиливает аддитивное взаимодействие ионов, формирующих кислотоустойчивый слой на поверхности дентина и дентинных канальцев, приводящее к снижению гиперестезии зубов
Hyperexpression of TLR2 and TLR4 in patients with ischemic stroke in acute period of the disease
Pathogenesis of ischemic stroke is actively involved in the system of innate immunity. Under conditions of cerebral ischemia, a number of biologically active substances are released that interact with innate immunity receptors, in particular TLR2 and TLR4, which exacerbate inflammation in brain tissue. Identification of predictor markers at the level of the innate immunity system may foresee the clinical course of ischemic stroke and ensure timely treatment. Our objective was to study expression of TLR2 and TLR4 receptors in peripheral blood leukocytes in patients with ischemic stroke in the dynamics of the disease. 27 people were included in the study. The main group consisted of patients with ischemic stroke of varying severity (n = 19). Patients of the main group were divided into two subgroups: with an NIHSS index value of < 10 (n = 10) and > 10 (n = 9). The control group included healthy donors with no history of acute and chronic inflammatory diseases (n = 8). Peripheral blood leukocytes were used as the test material. To determine expression of the TLR2 and TLR4 genes, RT-PCR in real time was used. Surface expression of TLRs was determined by flow cytometry. A study of the TLR2 and TLR4 gene expression showed that on the 1st, 3rd and 7th day post-stroke, the TLR4 gene expression in patients was significantly increased, when compared to the control group (p < 0.01), whereas TLR2 gene expression on the 3rd day of the disease was not statistically different from the control group. A study of surface expression of receptors showed that the average TLR2 fluorescence intensity on the patients’ peripheral blood monocytes was significantly increased on the 1st and 3rd day of disease when compared to the control group. The surface expression of TLR4 on monocytes has a statistically significant increase only on day 7. Assessment of surface expression of TLRs in subgroups with different severity values by NIHSS showed that patients with a NIHSS index > 10 had a significantly higher level of surface of TLR2 expression over the observation period, while the largest difference in TLR4 expression in the subgroups was observed on the 1st day of the disease (p < 0.05). Patients with ischemic stroke showed an increase in TLR2 and TLR4 expression at the gene and protein level, compared to healthy donors. These indices can be considered possible predictors for clinical prognosis of ischemic stroke
The increased sensitivity of dentin: the mechanisms of remineralization using toothpaste with tin fluoride
ВЕДЕНИЕ БЕРЕМЕННОСТИ, РОДОВ И ПОСЛЕРОДОВОГО ПЕРИОДА У ПАЦИЕНТКИ С ЛЕКАРСТВЕННО-УСТОЙЧИВЫМ, ДЕСТРУКТИВНЫМ ТУБЕРКУЛЕЗОМ ЛЕГКИХ ПОСЛЕ ЭТАПНОГО ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ
The article describes a clinical case of the successful management of pregnancy, delivery and post-natal period in the female patient with fibrous cavernous tuberculosis with extensive drug resistance and multiple thoracic surgeries in the past. This clinical case demonstrates that it is possible for a mother with the advanced form of tuberculosis to give birth to a healthy mature newborn.Представлено клиническое наблюдение успешного ведения беременности, родов и послеродового периода у пациентки с фиброзно-кавернозным туберкулезом с широкой лекарственной устойчивостью возбудителя и многократными торакальными операциями в анамнезе. Показана возможность рождения здорового доношенного ребенка у матери с тяжелой формой туберкулеза
Russian clinical practice guidelines «congenital adrenal hyperplasia»
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive diseases characterized by a defect in one of the enzymes or transport proteins involved in the cortisol synthesis in the adrenal cortex. The most common form of CAH, which occurs in more than 90% of cases, is a 21-hydroxylase enzyme deficiency. The latter is subdivided into nonclassical and classic (salt-losing and virilizing) forms. The prevalence of classic forms of 21-hydroxylase deficiency ranges from 1: 14,000 to 1:18,000 live births worldwide. According to the data of neonatal screening in the Russian Federation, the prevalence of the disease in some regions ranges from 1: 5000 to 1: 12000, in the country as a whole - 1: 9638 live newborns. The non-classical form of CAH occurs more often - from 1: 500 to 1: 1000 among the general population. In second place is the hypertensive form of CAH - a deficiency of 11β-hydroxylase, which, according to the literature, occurs in about 1 per 100,000 newborns. These clinical guidelines were compiled by a professional community of narrow specialists, approved by the expert council of the Ministry of Health of the Russian Federation, and updated the previous version published in 2016. The clinical guidelines are based on systematic reviews, meta-analyses and original articles, and scientific work on this issue in the Russian Federation and other countries. The purpose of this document is to provide clinicians with the most up-to-date, evidence-based guidelines for the CAH diagnosis and treatmen
Information and Analytical Support of Archaeological Research on the Basis of Digital Technologies
Our experience of radio-waved surgery in oral and maxillo-facial region
Surgical treatment of 53 patients with various pathologies of the soft tissues of the maxillofacial region using the radio wave surgery was performed. Clinical data indicate a high efficiency of radio wave surgery in the treatment of patients with soft tissue tumors of the face and oral cavity
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