СHANGES OF TLR GENE EXPRESSION IN CERVICAL EPITHELIUM FROM THE PATIENTS WITH UROGENITAL INFLAMMATORY DISEASES

Toll-like receptors (TLR) are involved into innate immune recognition of microorganisms, including pathogenic bacteria. The aim of this work is to assess relative levels of TLR2 and TLR9 expression in cervical epithelial cells of women with inflammatory diseases of pelvic organs. The total group of patients consisted of 47 persons, including 20 women with urogenital infections, and 27 women comprised a control group. Using real-time PCR, we identified the opportunistic pathogens and gene expression levels of TLR2, TLR9 in the cervix epithelial cells. It was shown that expression of TLR9 in the group with urogenital infections was 13.7-fold higher than in control group. We have revealed that a significant increase of TLR9 expression in the mucosal epithelium from cervical canal correlated with detection of infectious pathogens in the samples

Conceptual approach to innovational development of the university through the prism of a faculty

В статье обоснован подход к инновационному развитию университета через реорганизацию деятельности факультета как основной структурной единице вуза. Рассмотрены новые формы и условия организации партнерства университета и бизнеса по основным видам деятельности. Сформулированы концептуальные идеи и методические решения, направленные на сближение университетского обучения с кадровыми потребностями промышленности, а также вузовской науки с проблемами технологического развития предприятий.The article specifies the approach to innovational development of the university by reorganizing the faculty activity as it is the main structural unit of any educational establishment. New forms and conditions to organize partnership of university and business along the main lines of activity are considered. Conceptual ideas and methodical decisions aimed at bringing university education closer to industrial personnel requirements and university science closer to the issues of technological development of enterprises are formulated

Conceptual approach to innovational development of the university through the prism of a faculty

В статье обоснован подход к инновационному развитию университета через реорганизацию деятельности факультета как основной структурной единице вуза. Рассмотрены новые формы и условия организации партнерства университета и бизнеса по основным видам деятельности. Сформулированы концептуальные идеи и методические решения, направленные на сближение университетского обучения с кадровыми потребностями промышленности, а также вузовской науки с проблемами технологического развития предприятий.The article specifies the approach to innovational development of the university by reorganizing the faculty activity as it is the main structural unit of any educational establishment. New forms and conditions to organize partnership of university and business along the main lines of activity are considered. Conceptual ideas and methodical decisions aimed at bringing university education closer to industrial personnel requirements and university science closer to the issues of technological development of enterprises are formulated