Isoperiodic deformations of the acoustic operator and periodic solutions of the Harry Dym equation

We consider the problem of describing the possible spectra of an acoustic operator with a periodic finite-gap density. We construct flows on the moduli space of algebraic Riemann surfaces that preserve the periods of the corresponding operator. By a suitable extension of the phase space, these equations can be written with quadratic irrationalities.Comment: 15 page

METHODOLOGY FOR SELECTING PRIORITY REGIONAL CLUSTER DEVELOPMENT (the Volgograd region as the example)

Selecting priority of the creation of clusters is a highly relevant task at the present time, in the context of limited resources for regional development. This article discusses the complex methodology takes into account the macroand microeconomic approach, the specific structure of regional economy, the competitiveness of enterprises and products, and the potential of the investments projects, taking into account both the progress of the regional economic system and its potential for development through existing investment projects

МЕТОДИКА ОТБОРА ПРИОРИТЕТНЫХ НАПРАВЛЕНИЙ КЛАСТЕРНОГО РАЗВИТИЯ РЕГИОНА (на примере Волгоградской области)

Selecting priority of the creation of clusters is a highly relevant task at the present time, in the context of limited resources for regional development. This article discusses the complex methodology takes into account the macroand microeconomic approach, the specific structure of regional economy, the competitiveness of enterprises and products, and the potential of the investments projects, taking into account both the progress of the regional economic system and its potential for development through existing investment projects.В настоящее время весьма актуальной является задача отбора приоритетных направлений создания кластеров, в условиях ограниченности ресурсов для обеспечения регионального развития. В данной статье рассматриваются комплексная методика, учитывающая макрои микроэкономический подход, специфику структуры экономики региона, конкурентоспособность предприятий и выпускаемой продукции, потенциал предприятий и инвестиционных проектов, обеспечивающая учет, как достигнутых результатов развития региональной экономической системы, так и потенциал ее развития, за счет существующих инвестиционных проектов

Clinico-diagnostic peculiarities of dysplastic coxarthrosis of III-IV degree

CIinicodiagnostic researches included. 73 patients with dysplastic coxarthrosis who were examined and treated in orthopedic ward of Scientific Center of Reconstructive and. Restorative Surgery SB RAMS during 2001-2010 years. The aim. of the research is to specify clinic-radiologic criteria of hip joint with dysplastic changes at the arthrosis of III-IV degree. The diagnosis was set on the basis of clinicodiagnostic criteria. The main signs that characterize dysplastic joint were: anteversion of femoral neck; deflection of acetabulum anterior from sagittal plane; disorder of center of the head in horizontal plane; change of cervical-diaphyseal angle and. the angulation of acetabulum (more than 60°). Acetabulum becomes shallow and. head's embedding into it is Iess than 1/3 (1/2 as a norm). Main clinical manifestations of all examined patients were bending-adduction and rotation contractures of hip joints, shortening of extremities concerned with pathoIogic process, stabIe pain syndrome, gross Iimping with disorder of support function of extremity and Iocomotor act of waIking. In aII 73 patients we reveaIed. different disorders of anatomic interreIations of components of hip joint that are typicaI for grave forms of dyspIastic coxarthrosis. Ensuring of stabiIity of an impIant is extremeIy important at totaI hip joint repIacement. Prediction of measures of postoperative compIications prevention that allow to determine right tactics of operative treatment is the first to reaIize. If the indices of dyspIasia (ratio between thickness of acetabuIum's bottom and its depth) at dyspIastic coxarthrosis of III-IV degree is Iess than 0,6, it's possibIe to predict appearance of instabiIity of hip component of an impIant. VaIues of these indices can be used for forming impIant bed at the pIacing of impIant cup without additionaI ways of fixation

Changes in the immunological reactivity in patients with coxarthrosis and the factors that determine them

Background. The participation of immune responses in the pathogenesis of degenerative-dystrophic diseases of the synovial joints determines the feasibility of using more rational approaches to assessing the immune status of patients with this pathology. Despite the ongoing immunological studies in patients with degenerative-dystrophic diseases of the hip joint, there are questions related to the functioning of the immune system as a whole, which require additional research.The aim of the study was to establish the features of the relationship between the indicators of the immune status and to identify the factors that determine the nature and severity of immunological disorders in patients with coxarthrosis.Material and methods. The study is based on the results of immunological parameters in 73 patients (mean age – 45.3 ± 2.56 years) with stage III dysplastic coxarthrosis. The data obtained using cluster analysis made it possible to distribute patients into two groups. The first clinical group included 46 patients, the second one – 27 patients. The control group consisted of 28 clinically healthy individuals. Mathematical processing of the results was carried out using the Statistica 6.0 software package (StatSoft Inc., USA) and the mathematical package Mathcad 2001 Pro (MathSoft Inc., USA).Results. The levels of CD4+ and CD8+ cells and IgA were determined as the classification features that make the greatest contribution to the division of the studied groups. Model experiments have shown that a specific combination of the magnitude of each of the noted factors with a certain degree of probability makes it possible to assess the state of the initial immunological reactivity and verify the nature and severity of immunological disorders.Conclusion. The information obtained is of great importance, since it allows predicting the course of the recovery period after surgery and assessing the risk of developing possible postoperative complications in patients with severe articular pathology

Immunologic reactivity of an organism in patients with coxarthrosis in the assessment of risk of development of postoperative complications at the endoprosthesis replacement

It is known that research of immune system using separate parameters doesn't allow to estimate it as one. The aim of the work was to find new approaches to the estimation of immune system state for the determination of character and intensity of immunopathological manifestations in patients with hip joint pathology. We examined immune status in 73 patients with degenerative-dystrophic injuries and in 18 patients with posttraumatic hip joint injuries. We found the most significant immunological indices that allow to determine the state of immune reactivity of the patient before the operation. We identified two groups of patients: with presumably "compensated" and "subcompensated" form of immunodeficient state. It was shown that infectious infectious complications in the area of endoprosthesis appear in patients with low immune reactivity on the basis of calculation of equations of linear function in patients with posttraumatic coxarthrosis. The results of the research showed that it's not necessary to analyze many immunological indices to estimate the state of immune reactivity of an organism. Using discriminant analysis allows to reveal the determinant factors that characterize distinctness of Junctional state of immune system of a certain patient and to determine the risk of development of postoperative complications

ROLE OF INTERFERONS IN REGULATION OF OSTOGENIC AND OSTEORESORPTIVE PROCESSES

Bone tissue preserves high metabolic activity during all time of its life. Homeostasis of bone tissue is provided by fine balance between its formation by osteoblasts and its resorption by osteoclasts. There are complex regulatory interrelations between cells of bone differon and. system of interferons, the peculiarities of production of which mediate disturbances of osteoformating and. resorptive components of osteo metabolism at various pathological conditions. The review presents literature data on the role of interferons in regulation of osteogenous and. osteoresorptive processes which opens up the prospective of aimed application of interferons preparations with the purpose of restoration of immunologic imbalance and. bone tissue homeostasis

Complications at the hip replacement and ways of their prediction (review of literature)

The review presents modern data on the role of immune system in development of postoperative complications at hip replacement. Surgical stress while having depressive influence on immune system is powerful factor that causes conditions for development of secondary immune depression or intensifies it. On this background possibility of development of both early and late postoperative complications is quite high, that's why frequency of revision hip replacement increases steadily. Providing of stability of endoprosthesis is extremely important at total hip replacement. Researches realized during last decades determined connection of processes of osteogenesis and bone resorption and polypeptide factors of growth - cytokines. That's why questions of prevention and. correction of loss of bone substance with use of modern pharmacological preparations are important in the movement of observed problem. Infectious complications are also very significant ones at hip replacement. The fact of infectious process being the result of interrelation of macro- and. microorganisms and. immune system having one the leading roles in this process is doubtless. Among all the measures for prevention of postoperative complications their prevention that allows to determine right tactics of operative treatment, to realize complex of preparatory and. rehabilitation measures and. to improve the results of treatment and quality of life of patient, becomes important. Use of immunologic methods allowed to choose criteria and to develop ways of prevention of development of complications at hip replacement. However proposed ways not always allow to count individual susceptibility of an organism to different infectious pathogens; most of them are based on the determination of various specific and. quite laborious indices. Necessity of realization of researches before an operation and. in different terms of postoperative period for determination of dynamic dependence of changes of laboratory indices is significant disadvantage and requires quite prolonged observation of the patient for getting an information about prevention of hip replacement results. That's why further development and use of new ways of early hip replacement undoubtedly allows to improve results of surgical treatment of patients with different forms of coxarthrosis

Relationship of Immune Status Indicators and Hormonal Profile in Patients with Coxarthrosis

Background. The dynamic balance between the immune and neuroendocrine systems and their mutual regulation provide the formation of protective reactions of the body in conditions of pathology and various stress-inducing effects. The aim of the research was to establish the nature of the relationship between the indicators of the immune status and hormonal profile in patients with coxarthrosis before and after hip replacement.Material and methods. The study involved 73 patients with stage HI dysplastic coxarthrosis, who, using cluster analysis according to immunological parameters, were divided into two groups. The first clinical group included 46 patients, the second - 27 patients. The control group consisted of 28 clinically healthy individuals.Results. In the preoperative period, correlations between indicators of the immune status and hormonal profile were different in patients of the 1st and 2nd groups and depended on the level of hormones. Moreover, in patients of the 1st group, the hormones of the stress-limiting system made the greatest contribution to this dependence, and in patients of the 2nd group - peripheral thyroid hormones. After endoprosthetics, the correlation dependence in patients of the 1st group differed from the initial one in a number of indicators of the immune status and hormonal profile, which reflects the coordinated work of these body systems under the influence of stress factors. In patients of the 2nd group, the spectrum of these indicators was limited, which indicates the failure ofmechanisms, in particular, limiting the intensity ofinflammatory reactions after surgery.Conclusion. The relationship of the studied parameters in patients of the 1st group indicates the adaptive nature of the immune and endocrine reactions in response to surgery. In patients of the 2nd group, they reflect disadaptive rearrangement, which leads to an increased risk of postoperative complications