Defeat Hepatobiliary System and Pancreas in Inflammatory Bowel Disease

Extraintestinal manifestations and complications of inflammatory bowel disease currently represents one of the most mysterious phenomenon in gastroenterology. Special interest is caused damages of liver, biliary system and pancreas, as constituent organs of the digestive system and first responders not only to inflammation of the intestinal mucosa, but also for medicines taken by patients for induction and maintenance of remission

Intestinal and Extraintestinal Manifestations of Inflammatory Bowel Disease

The problem of inflammatory bowel disease draws constant attention not only of gastroenterologists but also surgeons - coloproctologists and other doctors. These related to the growing incidence of this pathology in the world, as well as the diversity of clinical manifestations, including severe extraintestinal manifestations and complications, which in clinical practice, faced not only gastroenterologists. In most cases, inflammatory bowel disease leads to permanent disability cases, which makes this problem not only medical but also socially relevant

FEATURES MICROBIOCENOSIS SHEATH IN WOMEN REPRODUCTIVE AGE WITH HYSTEROMYOMA

Purpose: To examine the state of the vaginal flora in women of late reproductive age with hysteromyoma.Materials and Methods: The study included 40 women aged 35 to 44 years diagnosed with hysteromyoma. All patients performed a microscopic and bacteriological examination of the vaginal flora.Results: In patients with hysteromyoma into the sheath showed a reduction in the number of lactobacilli, bifidobacteria and increase the detection rate and the number of nonclostridial anaerobic bacteria.Summary: hysteromyoma accompanied by changes in vaginal microflora

First year infant motor asymmetry origins and prevention: parental awareness survey

Objective of the study was to survey the parental awareness of the origins of infant motor asymmetry and its prevention method

Assessment of the physical development and metabolic status of children born to women with gestational diabetes

Backgraund: Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders found during pregnancy. Currently, it is relevant not only to search optimal target levels of glycemia during pregnancy, but also to study the ­effect of different glycemia levels on fetal development and further changes in glucose and lipid metabolism in children.Aims: To describe perinatal period, physical development and metabolic status of children born to women with GDM and different glucose levels during pregnancy.Materials and methods: The perinatal period features and anthropometric parameters at birth were evaluated in 300 children born to women with GDM and different levels of glycemia during pregnancy. Over the course two years, 141 children have been evaluated for physical development parameters and glucose and lipid metabolism. Fasting and postprandial glycemia was measured with glucometer for 14 days in 33 children aged 1 to 4 years.Results: The anthropometric parameters of children at birth did not differ from the parameters of the control group (p> 0.05) when during pregnancy fasting blood glucose was less than 5.1 mmol / l and 7.0 mmol / l 1 hour after a meal. The glycemia in women above this level was associated with an increase of frequency and risk of a body mass index, body mass / length ratio and head circumference “above average” in children at birth (p <0.05). With the dynamic control of anthropometric parameters up to 2 years, no differences between the comparison groups were obtained (p> 0.05). The change in metabolic parameters was represented by neonatal hypoglycemia in children of GDM group (GDM group — 23%, control group — 3.5%, p = 0.000002), the least risk of which occurred in group with the lowest fasting and postprandial glycemic values during pregnancy. Fasting glucose, and insulin levels, НOMA index, triglycerides and cholesterol, as well as monitoring fasting and postprandial glycemia for 14 days, were obtained no significant differences between the comparison groups of children (p> 0.05).Conclusions: The lowest risks of neonatal hypoglycemia and anthropometric deviations at birth were associated with the lowest glycemia levels during pregnancy, which correspond to the criteria of the Russian clinical guidelines

Structure-Sensitive Mechanism of Nanographene Failure

The response of a nanographene sheet to external stresses is considered in terms of a mechanochemical reaction. The quantum chemical realization of the approach is based on a coordinate-of-reaction concept for the purpose of introducing a mechanochemical internal coordinate (MIC) that specifies a deformational mode. The related force of response is calculated as the energy gradient along the MIC, while the atomic configuration is optimized over all of the other coordinates under the MIC constant-pitch elongation. The approach is applied to the benzene molecule and (5, 5) nanographene. A drastic anisotropy in the microscopic behavior of both objects under elongation along a MIC has been observed when the MIC is oriented either along or normally to the C-C bonds chain. Both the anisotropy and high stiffness of the nanographene originate at the response of the benzenoid unit to stress.Comment: 19 pages, 7 figures 1 tabl

The interplay between learner beliefs and foreign language anxiety: insights from the Turkish EFL context

Foreign language learning in classroom settings has long been found to be associated with anxiety (Horwitz, 1986). Though it is known that sources of foreign language anxiety are varied (Young, 1991), whether anxiety is related to learners’ inherent beliefs about language learning is understudied. To this end, the present study examines the possible relationship between learner beliefs and language anxiety in the under-researched Turkish EFL context. A population of university-level Turkish EFL learners (n=153) completed the Beliefs about Language Learning Inventory (BALLI) and the Foreign Language Classroom Anxiety scale (FLCAS). The underlying constructs in both instruments were explored using an Exploratory Factor Analysis (EFA). A series of Pearson Product-Moment Correlation Coefficient (PPMCC) tests were performed on the factor scores from both instruments. The findings revealed that fear of ambiguity was positively linked to classroom performance anxiety and negative feelings towards English. In addition, the more confident learners feel themselves using English, the more desire they seem to have to interact with native speakers. Overall, positive beliefs about language learning may be helpful in reducing anxiety and boosting confidence in language learning. These findings not only enhance our understanding of the complex psychology of language learning but also have important implications for instructed EFL/ESL settings

СУЧАСНІ МЕТОДИ ДІАГНОСТИКИ ТА ЛІКУВАННЯ ХВОРИХ З ГІПЕРПЛАСТИЧНИМИ ПРОЦЕСАМИ ЕНДО- ТА МІОМЕТРІЯ.

The features of the receptor status and role of endometrial proliferation markers in the development of hyperplasia and features of response to treatment with hyperplastic diseases of the uterus. In this clinical study was shown that endometrial hyperplasia is not only the result of increased cell proliferation, but also result in different directions and impaired expression of progesterone receptors and estrogen. Research receptor status and proliferative endometrium in women with uterine hyperplastic processes contributed to the definition of adequate treatment policy, reducing the number of relapses and complications, improving the quality of life of patients and improve the long-term effects of treatment. The proposed use levonorgestrel-system intrauterine in endometrial hyperplasia has many benefits on psychological status and quality of life p a i n t s reproductive and premenopausal age.Исследованы особенности рецепторного статуса эндометрия и роль маркеров пролиферации в развитии гиперплазии и особенностях ответа на лечение при гиперпластических заболеваниях матки. В проведенном исследовании было доказано, что гиперпластические процессы эндометрия являются не только результатом повышенной клеточной пролиферации, но и следствием нарушенной и разнонаправленной экспрессии рецепторов прогестерона и эстрогенов. Исследование рецепторного и пролиферативного статуса эндометрия у женщин с гиперпластическими процессами матки способствовало определению адекватной лечебной тактики, уменьшению количества рецидивов и осложнений, улучшению качества жизни больных и лучшению отдаленных результатов лечения. Предложенное использование внутриматочной системы с левоноргестрелом при гиперпластических процессах эндометрия имеет много преимуществ в отношении психологического состояния и качества жизни пациенток репродуктивного и пременопаузального возраста.Досліджено особливості рецепторного статусу ендометрія та роль маркерів проліферації в розвитку гіперплазії та особливостях відповіді на лікування при гіперпластичних захворюваннях матки. В проведеному дослідженні було доведено, що гіперпластичні процеси ендометрія є не тільки результатом підвищеної клітинної проліферації, але й наслідком порушеної та різноспрямованої експресії рецепторів прогестерону та естрогенів. Дослідження рецепторного та проліферативного статусу ендометрія у жінок з гіперпластичними процесами матки сприяло визначенню адекватної лікувальної тактики, зменшенню кількості рецидивів і ускладнень, покращенню якості життя хворих та поліпшенню віддалених наслідків лікування. Запропоноване використання внутрішньоматкової системи з левоноргестрелом при гіперпластичних процесах ендометрія має багато переваг щодо психологічного стану та якості життя пацієнток репродуктивного та пременопаузального віку

Photochemistry of Furyl- and Thienyldiazomethanes: Spectroscopic Characterization of Triplet 3-Thienylcarbene

Photolysis (λ \u3e 543 nm) of 3-thienyldiazomethane (1), matrix isolated in Ar or N2 at 10 K, yields triplet 3-thienylcarbene (13) and α-thial-methylenecyclopropene (9). Carbene 13 was characterized by IR, UV/vis, and EPR spectroscopy. The conformational isomers of 3-thienylcarbene (s-E and s-Z) exhibit an unusually large difference in zero-field splitting parameters in the triplet EPR spectrum (|D/hc| = 0.508 cm–1, |E/hc| = 0.0554 cm–1; |D/hc| = 0.579 cm–1, |E/hc| = 0.0315 cm–1). Natural Bond Orbital (NBO) calculations reveal substantially differing spin densities in the 3-thienyl ring at the positions adjacent to the carbene center, which is one factor contributing to the large difference in D values. NBO calculations also reveal a stabilizing interaction between the sp orbital of the carbene carbon in the s-Z rotamer of 13 and the antibonding σ orbital between sulfur and the neighboring carbon—an interaction that is not observed in the s-E rotamer of 13. In contrast to the EPR spectra, the electronic absorption spectra of the rotamers of triplet 3-thienylcarbene (13) are indistinguishable under our experimental conditions. The carbene exhibits a weak electronic absorption in the visible spectrum (λmax = 467 nm) that is characteristic of triplet arylcarbenes. Although studies of 2-thienyldiazomethane (2), 3-furyldiazomethane (3), or 2-furyldiazomethane (4) provided further insight into the photochemical interconversions among C5H4S or C5H4O isomers, these studies did not lead to the spectroscopic detection of the corresponding triplet carbenes (2-thienylcarbene (11), 3-furylcarbene (23), or 2-furylcarbene (22), respectively)

Effects of Mechanical Interaction Between Two Rabbit Cardiac Muscles Connected in Parallel

Abstract. The hypothesis that myocardium mechanical inhomogeneity produces a substantial effect on mechanical function was tested. Muscle inhomogeneity was studied in isolated papillary muscles or trabeculae excised from rabbit right ventricle and connected in a parallel duplex. Each muscle was placed in a separate perfusion bath. One end of each muscle was fastened to an individual force transducer and the other to the common lever of a servomotor. This arrangement allowed both muscles, being excited independently, to pull jointly a load applied to the lever. Separate electrodes for each perfusion bath allowed to stimulate muscles with a time delay. Tension developed in the individual muscles and their interaction were studied. Developed tension was critically dependent on the timing and sequence of excitation. Using mathematical modeling, patterns of tension distribution experimentally observed in parallel duplexes were simulated. These results suggest that changes both in Ca 2+ transients and in the time course of Ca 2+ -troponin complexion due to the duplexed muscles interaction offset the effect of mechanical inhomogeneity