A low dimensional dynamical system for the wall layer

Low dimensional dynamical systems which model a fully developed turbulent wall layer were derived.The model is based on the optimally fast convergent proper orthogonal decomposition, or Karhunen-Loeve expansion. This decomposition provides a set of eigenfunctions which are derived from the autocorrelation tensor at zero time lag. Via Galerkin projection, low dimensional sets of ordinary differential equations in time, for the coefficients of the expansion, were derived from the Navier-Stokes equations. The energy loss to the unresolved modes was modeled by an eddy viscosity representation, analogous to Heisenberg's spectral model. A set of eigenfunctions and eigenvalues were obtained from direct numerical simulation of a plane channel at a Reynolds number of 6600, based on the mean centerline velocity and the channel width flow and compared with previous work done by Herzog. Using the new eigenvalues and eigenfunctions, a new ten dimensional set of ordinary differential equations were derived using five non-zero cross-stream Fourier modes with a periodic length of 377 wall units. The dynamical system was integrated for a range of the eddy viscosity prameter alpha. This work is encouraging

Multifractal spectra in homogeneous shear flow

Employing numerical simulations of 3-D homogeneous shear flow, the associated multifractal spectra of the energy dissipation, scalar dissipation and vorticity fields were calculated. The results for (128) cubed simulations of this flow, and those obtained in recent experiments that analyzed 1- and 2-D intersections of atmospheric and laboratory flows, are in some agreement. A two-scale Cantor set model of the energy cascade process which describes the experimental results from 1-D intersections quite well, describes the 3-D results only marginally

A study of air-to-ground sound propagation using an instrumented meteorological tower

The results of an exploratory NASA study, leading to a better understanding of the effects of meteorological conditions on the propagation of aircraft noise, are reported. The experimental program utilized a known sound source fixed atop an instrumented meteorological tower. The basic experimental scheme consisted of measuring the amplitude of sound radiated toward the ground along a line of microphones fixed to a tower guy wire. Experimental results show the feasibility of this approach in the acquisition of data indicating the variations encountered in the time-averaged and instantaneous amplitudes of propagated sound. The investigation included a consideration of ground reflections, a comparison of measured attenuations with predicted atmospheric absorption losses, and an evaluation of the amplitude fluctuations of recorded sound pressures

Ejection mechanisms in the sublayer of a turbulent channel

A possible model for the inception of vorticity ejections in the viscous sublayer of a turbulent rectangular channel is presented. It was shown that this part of the flow is dominated by protruding strong shear layers of z-vorticity, and it was proposed as a mechanism for their maintenance and reproduction which is essentially equivalent to that responsible for the instability of 2-D Tollmien-Schlichting waves. The efforts to isolate computationally a single structure for its study have failed up to now, since it appears that single structures decay in the absence of external forcing, but a convenient computation model was identified in the form of a long and narrow periodic computational box containing at each moment only a few structures. Further work in the identification of better reduced systems is in progress

A numerical study of bifurcations in a barotropic shear flow

In the last few years, more and more evidence has emerged suggesting that transition to turbulence may be viewed as a succession of bifurcations to deterministic chaos. Most experimental and numerical observations have been restricted to Rayleigh-Benard convection and Taylor-Couette flow between concentric cylinders. An attempt is made to accurately describe the bifurcation sequence leading to chaos in a 2-D temporal free shear layer on the beta-plane. The beta-plane is a locally Cartesian reduction of the equations describing the dynamicss of a shallow layer of fluid on a rotating spherical planet. It is a valid model for large scale flows of interest in meteorology and oceanography

Analysis of screeching in a cold flow jet experiment

The screech phenomenon observed in a one-sixtieth scale model space shuttle test of the solid rocket booster exhaust flow noise has been investigated. A critical review is given of the cold flow test data representative of Space Shuttle launch configurations to define those parameters which contribute to screech generation. An acoustic feedback mechanism is found to be responsible for the generation of screech. A simple equation which permits prediction of screech frequency in terms of basic testing parameters such as the jet exhaust Mach number and the separating distance from nozzle exit to the surface of model launch pad is presented and is found in good agreement with the test data. Finally, techniques are recommended to eliminate or reduce the screech

Disordered Regimes of the one-dimensional complex Ginzburg-Landau equation

I review recent work on the ``phase diagram'' of the one-dimensional complex Ginzburg-Landau equation for system sizes at which chaos is extensive. Particular attention is paid to a detailed description of the spatiotemporally disordered regimes encountered. The nature of the transition lines separating these phases is discussed, and preliminary results are presented which aim at evaluating the phase diagram in the infinite-size, infinite-time, thermodynamic limit.Comment: 14 pages, LaTeX, 9 figures available by anonymous ftp to amoco.saclay.cea.fr in directory pub/chate, or by requesting them to [email protected]

A non-invasive method for measuring preimplantation embryo physiology

Author Posting. © Cambridge University Press, 2000. This article is posted here by permission of Cambridge University Press for personal use, not for redistribution. The definitive version was published in Zygote 8 (2000): 15-24, doi:10.1017/S0967199400000782.The physiology of the early embryo may be indicative of embryo vitality and therefore methods for non-invasively monitoring physiological parameters from embryos could improve preimplantation diagnoses. The self-referencing electrophysiological technique is capable of non-invasive measurement of the physiology of individual cells by monitoring the movement of ions and molecules between the cell and the surrounding media. Here we use this technique to monitor gradients of calcium, potassium, oxygen and hydrogen peroxide around individual mouse preimplantation embryos. The calcium-sensitive electrode in self-referencing mode identified a region of elevated calcium concentration ([similar]0.25 pmol) surrounding each embryo. The calcium gradient surrounding embryos was relatively steep, such that the region of elevated calcium extended into the medium only 4 [mu]m from the embryo. By contrast, using an oxygen-sensitive electrode an extensive gradient of reduced dissolved oxygen concentration was measured surrounding the embryo and extended tens of micrometres into the medium. A gradient of neither potassium nor hydrogen peroxide was observed around unperturbed embryos. We also demonstrate that monitoring the physiology of embryos using the self-referencing technique does not compromise their subsequent development. Blastocysts studied with the self-referencing technique implanted and developed to term at the same frequency as did unexamined, control embryos. Therefore, the self-referencing electrode provides a valuable non-invasive technique for studying the physiology and pathophysiology of individual embryos without hindering their subsequent development.A portion of this work was funded by an NIH R21 #RR 12718–02 to D.L.K. and P.J.S.S., KO81099 to D.L.K. and NIH P41 RR01395 to P.J.S.S

Aliskiren, an Oral Renin Inhibitor, Provides Dose-Dependent Efficacy and Sustained 24-Hour Blood Pressure Control in Patients With Hypertension

ObjectivesThis dose-ranging study evaluated the antihypertensive efficacy and tolerability of aliskiren in patients with mild-to-moderate hypertension.BackgroundLow blood pressure (BP) control rates among patients with hypertension indicate a need for improved treatment options. This study investigates aliskiren, the first in a new antihypertensive class called renin inhibitors.MethodsPatients with mean sitting diastolic BP 95 to 109 mm Hg were randomized to aliskiren 150, 300, or 600 mg or placebo once daily for 8 weeks. Patients completing this treatment phase entered a 2-week treatment-free withdrawal period. Office BP was recorded at baseline, weeks 2, 4, 6, and 8 of treatment, and 4 days and 2 weeks after cessation of treatment. A subgroup of patients underwent ambulatory BP monitoring.ResultsIn total, 672 patients were randomized to treatment. After 8 weeks, aliskiren 150, 300, and 600 mg significantly reduced mean sitting BP (systolic/diastolic) by 13.0/10.3, 14.7/11.1, and 15.8/12.5 mm Hg, respectively, versus 3.8/4.9 mm Hg with placebo (all p < 0.0001 for systolic and diastolic BP). The BP-lowering effect of aliskiren persisted for up to 2 weeks after treatment withdrawal. Aliskiren significantly reduced mean 24-h ambulatory BP (p < 0.0001 vs. placebo with all doses) exhibiting smooth, sustained effects and high trough-to-peak ratios. Aliskiren was well tolerated; overall adverse event rates were 40.1%, 46.7%, and 52.4% with aliskiren 150, 300, and 600 mg, respectively, and 43.0% with placebo. Few patients discontinued treatment due to adverse events.ConclusionsAliskiren provides significant antihypertensive efficacy in patients with hypertension, with no rebound effects on blood pressure after treatment withdrawal