К 120-летию Н. П. Герасимова

Doctor of Geological and Mineralogical Sciences, Professor Gerasimov N.P. served as Head of the Department of Historical Geology and Paleontology in the Perm State University from 1938 until 1952. A brief information on his educational, scientific, industrial, organizational and pedagogical activity is given.Приведены краткие сведения об учебно-научной и производственноорганизационной и педагогической деятельности доктора геолого-минералогических наук, профессора Н.П. Герасимова, заведующего кафедрой исторической геологии и палеонтологии Пермского госуниверситета в 1938-1952 гг

Моделирование процессов формирования нефтегазоносности Вычегодского прогиба

The article is devoted to reconstruction of the conditions of oil and gas potential formation in the Vychegda Trough using 2D basin modeling. Currently, the region is very poorly studied that is indicated by the low density of the entire fund of drilled wells and explored regional seismic profiles. However, the Vychegda Trough is considered as a prospective area for new oil and gas fields in the North-East of European Russia. The amount of information accumulated during the entire period of study of the Vychegda Trough makes it possible to conduct a comprehensive study of the processes of oil and gas potential formation and assess the perspectives of oil and gas bearing capacity using a modern basin modeling method.Статья посвящена реконструкции условий формирования нефтегазоносности Вычегодского прогиба с использованием 2D бассейнового моделирования. В настоящий момент регион изучен крайне слабо, на что указывают низкая плотность сетки всего фонда пробуренных скважин и отработанных региональных сейсморазведочных профилей. Тем не менее Вычегодский прогиб считается перспективной территорией на поиски новых месторождений нефти и газа на Северо-Востоке Европейской части России. Объем информации, накопленной за весь период изучения Вычегодского прогиба, дает возможность провести комплексное исследование процессов формирования нефтегазоносного потенциала и оценить перспективы нефтегазоносности с помощью современного метода – бассейнового моделирования

Developments of scientific and methodical competence of the teacher of pedagogical higher education institution of operating conditions of the educational cluster

In article the problem of development of scientific and methodical competence of the teacher of technical college of operating conditions of a regional and branch educational cluster is considered. The structure and the maintenance of the specified competence and functionality of its development is analyzed.Рассматривается проблема развития научно-методической компетентности преподавателя педагогического вуза в условиях функционирования регионально-отраслевого образовательного кластера. Анализируются структура и содержание указанной компетентности и функциональные возможности ее развития

Experience in the Implementation of Regional Concepts for the Development of the Circular “Green” Economy of the Countries of the World

The purpose of this study is to determine in which directions the measures of the “green” economy are being implemented in foreign countries. To achieve this goal, the concept of a “green” economy and a “circular” economy was given; national strategies of the “green” economy of foreign countries were studied; the main directions of “green” regional initiatives were identified; measures taken in foreign countries in the selected areas of the “green” economy were compared. The subject of the study is foreign strategies for the development of the “green” economy of the region. The object of research is the “green” economy. The authors apply methods of empirical research (description and comparison); general logical (analysis of information, its synthesis and generalization, as well as abstraction); theoretical cognition (hypotic-deductive; ascent from the abstract to the concrete). The article considers examples of the implementation of foreign national concepts for the development of a “green” economy, which are associated with regional initiatives of Germany, the United Arab Emirates, Canada, Belgium and the United States of America. The analysis is made on the basis of national strategies of the “green” economy, directions and initiatives. It is concluded that these examples of the implementation of the “greening” of the economy should be taken as an example for other countries, since work in this direction can improve the environmental situation, the quality of life of the country and a particular region

PHARMACOCORRECTION PHYSICAL PERFORMANCE HERBAL REMEDIES «KARDEKAIM»

The purpose of this study was to determine the effect of herbal means «kardekaim» on indicators of physical endurance. Actoprotective activity was determined by the general models, high-speed and power of physical endurance in experiments on white mice. Overall physical endurance was determined by the duration of the swimming pool in mice with a load, speed of physical endurance was assessed by running the length of the mice in the 10-track treadmill, strength endurance were evaluated by retention time on a pole mice. Found that the introduction of rnurse «kardekaim» increases overall, speed and power physical endurance of laboratory animals against peace. On the model of single-and multiple-dose exercise kardekaim increases the potential for physical performance, prevents fatigue and speeds up recovery of physical endurance of animals undergoing high intensity exercise. The most effective kardekaim shows at course introduction. It is proved that the effect of the introduction at course «kardekaim» superior product comparison - Eleutherococcus extract

NOVEL APPROACHES TO TREATING NONSPECIFIC LOW BACK PAIN

Objective: to evaluate the impact of therapy with chondroitin sulfate (CS) and glucosamine (GA) on the clinical manifestations of low back pain (LBP).Subjects and methods. A multicenter open-label observational prospective study was conducted in 22 cities of Russia (46 centers) to investigate the efficacy of a combination of CS and GA in the outpatient treatment of nonspecific LBP. A total of 9761 patients were enrolled in the study that was completed by 8546 patients. Therapeutic efficiency was evaluated from changes in pain intensity during movement and at rest, by using the visual analogue scale. The Oswestry disability index, an global physician and patient assessment of therapeutic efficiency, and a daily need for nonsteroidal anti-inflammatory drugs (NSAIDs) were taken into account as additional criteria for efficiency evaluation.Results and discussion. The multicenter open-label observational study established the efficacy of a combination of CS and GA in treating nonspecific LBP: relief in pain during movement and at rest, functional improvement, and a reduction in the daily need for NSAIDs. The patients and physicians highly assessed therapeutic efficiency. The combination of CS and GA was also noted to be well tolerated. The findings may suggest that this combination may be a promising tool to treat LBP and gives proof to the expediency of its use in randomized placebo-controlled studies

ADVANCED THERAPY IN PATIENTS WITH PRIMARY AND POSTPOLYCYTHEMIC MYELOFIBROSIS

Ph-negative myeloproliferative neoplasm are the group of hematologic disorders which includes primary myelofibrosis, polycythemia vera, essential trombocytemia and several rare diseases. After the discovery of V617 Fgain-of-function mutation the new period of diagnostics, treatment and evaluating of MPN prognosis began. At the current moment several molecules inhibiting JAK2 function are developed. Advanced therapy in patients with primary and post-polycythemic myelofibrosis included molecules inhibiting JAK2 function resulted in rapid and durable improvements in splenomegaly and disease-related symptoms in the phase 3 trials COMFORT-I and COMFORT-II. The effectiveness of the advanced therapy included molecule inhibiting JAK2 was evaluated in three patients with primary myelofibrosis and post-polycitemic myelofibrosis. All represented clinical cases demonstrated positive dynamics of the disease manifested in spleen size reduction, improvement of the symptoms and in one case in reduction of blood transfusions. None of three patients met serious adverse events leading to dose reduction or discontinuation of the molecule inhibiting JAK2. Target agents therapy demonstrated high treatment rates in patients with primary and post-polycythemic myelofibrosis. Thus, it is clearly necessary to perform molecular diagnosis, screening tests at early stages of the chronic myeloproliferative disease for the selection of patients in need for specific treatment

Gastrointestinal Bleeding in Antithrombotic Therapy in Patients with Coronary Heart Disease: Risk Factors, Pathogenesis and Treatment

Aim. Description of risk factors, pathogenesis and treatment strategies of gastrointestinal bleeding (GIB) in the course of antithrombotic therapy in patients with coronary heart disease (CHD).Key points. Risk factors of GIB during antithrombotic therapy in CHD patients include: GIB, gastric and/or duodenal ulcer in the history, reflux esophagitis, presence of H. pylori, inflammatory bowel disease, diverticula, haemorrhoids, angiodysplasia, gastrointestinal neoplasia, age above 65 years, concomitant treatment with non-steroidal anti-inflammatory drugs (NSAIDs), glomerular filtration rate <50 mL/min, high doses of direct oral anticoagulants (DOACs) ≥3 in HAS-BLED score. Pathogenesis of GIB in the course of antithrombotic therapy is associated with systemic hypocoagulation and local damaging effects of these drugs. Strategies of GIB treatment during DOAC therapy in patients with CHD are determined by severity of bleeding and threat to life. Aside to standard conservative measures, endoscopic or surgical haemostasis requires usage of antidotes to suppress effects of DOACs and other specific drugs in severe cases.Conclusion. GIB associated with antithrombotic therapy in CHD patients poses a serious medical problem of growing importance with wider application of anticoagulant drugs. Antithrombotic therapy requires accurate decision making, risk assessment, careful monitoring of the patient’s condition and timely diagnosis of gastrointestinal disorders following good rationale in GIB prevention

NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESIS

Role of nitric oxide in the pathogenesis of pulmonary tuberculosis has been studied in 77 patients with new infiltrate pulmonary tuberculosis and 34 patients with fibrous cavernous pulmonary tuberculosis. The level of cumulative and endogenous nitrite depended on the clinical form of tuberculosis: in infiltrate pulmonary tuberculosis patients it was within the limits of reference ranges, and in fibrous cavernous pulmonary tuberculosis patients it was significantly lower. Results of statistical analysis point out at the significant homogeneity (monofunctionality) of the set of rates, defining the level of NO metabolites in blood serum in infiltrate pulmonary tuberculosis, namely: impact of adenosine deaminase, levels of α1-protease inhibitor, ceruleoplasmin and age. On the contrary in case of fibrous cavernous pulmonary tuberculosis the diverse (multi-functional) complexes were detected including clinical blood rates providing influence on the reduction of NO level in blood. Nitric oxide in the patients with both clinical forms of tuberculosis correlated with classical markers of system inflammatory response, thus nitric oxide can be regarded as an integral component of inflammatory response with potential evaluation of prognosis of specific lesions during follow-up of changes