5,953 research outputs found
Spatially Resolved Gas Kinematics within a Ly Nebula: Evidence for Large-scale Rotation
We use spatially extended measurements of Ly as well as less
optically thick emission lines from an 80 kpc Ly nebula at
to assess the role of resonant scattering and to disentangle
kinematic signatures from Ly radiative transfer effects. We find that
the Ly, CIV, HeII, and CIII] emission lines all tell a similar story in
this system, and that the kinematics are broadly consistent with large-scale
rotation. First, the observed surface brightness profiles are similar in extent
in all four lines, strongly favoring a picture in which the Ly photons
are produced in situ instead of being resonantly scattered from a central
source. Second, we see low kinematic offsets between Ly and the less
optically thick HeII line (100-200 km s), providing further
support for the argument that the Ly and other emission lines are all
being produced within the spatially extended gas. Finally, the full velocity
field of the system shows coherent velocity shear in all emission lines:
500 km s over the central 50 kpc of the nebula. The
kinematic profiles are broadly consistent with large-scale rotation in a gas
disk that is at least partially stable against collapse. These observations
suggest that the Ly nebula represents accreting material that is
illuminated by an offset, hidden AGN or distributed star formation, and that is
undergoing rotation in a clumpy and turbulent gas disk. With an implied mass of
M(<R=20 kpc) , this system may represent the
early formation of a large Milky Way mass galaxy or galaxy group.Comment: Accepted to ApJ; 25 pages in emulateapj format; 15 figures, 4 table
An LED-based Flasher System for VERITAS
We describe a flasher system designed for use in monitoring the gains of the
photomultiplier tubes used in the VERITAS gamma-ray telescopes. This system
uses blue light-emitting diodes (LEDs) so it can be operated at much higher
rates than a traditional laser-based system. Calibration information can be
obtained with better statistical precision with reduced loss of observing time.
The LEDs are also much less expensive than a laser. The design features of the
new system are presented, along with measurements made with a prototype mounted
on one of the VERITAS telescopes.Comment: Accepted for publication in Nuclear Instruments and Methods in
Physics Research
The Stripe 82 1-2 GHz Very Large Array Snapshot Survey: Multiwavelength Counterparts
We have combined spectrosopic and photometric data from the Sloan Digital Sky
Survey (SDSS) with GHz radio observations, conducted as part of the
Stripe 82 GHz Snapshot Survey using the Karl G. Jansky Very Large Array
(VLA), which covers sq degrees, to a flux limit of 88 Jy rms.
Cross-matching the radio source components with optical data via
visual inspection results in a final sample of cross-matched objects,
of which have spectroscopic redshifts and objects have
photometric redshifts. Three previously undiscovered Giant Radio Galaxies
(GRGs) were found during the cross-matching process, which would have been
missed using automated techniques. For the objects with spectroscopy we
separate radio-loud Active Galactic Nuclei (AGN) and star-forming galaxies
(SFGs) using three diagnostics and then further divide our radio-loud AGN into
the HERG and LERG populations. A control matched sample of HERGs and LERGs,
matched on stellar mass, redshift and radio luminosity, reveals that the host
galaxies of LERGs are redder and more concentrated than HERGs. By combining
with near-infrared data, we demonstrate that LERGs also follow a tight
relationship. These results imply the LERG population are hosted by population
of massive, passively evolving early-type galaxies. We go on to show that
HERGs, LERGs, QSOs and star-forming galaxies in our sample all reside in
different regions of a WISE colour-colour diagram. This cross-matched sample
bridges the gap between previous `wide but shallow' and `deep but narrow'
samples and will be useful for a number of future investigations.Comment: 17 pages, 19 figures. Resubmitted to MNRAS after the initial comment
Very small deletions within the NESP55 gene in pseudohypoparathyroidism type 1b
Pseudohypoparathyroidism (PHP) is caused by reduced expression of genes within the GNAS cluster, resulting in parathormone resistance. The cluster contains multiple imprinted transcripts, including the stimulatory G protein α subunit (Gs-α) and NESP55 transcript preferentially expressed from the maternal allele, and the paternally expressed XLas, A/B and antisense transcripts. PHP1b can be caused by loss of imprinting affecting GNAS A/B alone (associated with STX16 deletion), or the entire GNAS cluster (associated with deletions of NESP55 in a minority of cases). We performed targeted genomic next-generation sequencing (NGS) of the GNAS cluster to seek variants and indels underlying PHP1b. Seven patients were sequenced by hybridisation-based capture and fourteen more by long-range PCR and transposon-mediated insertion and sequencing. A bioinformatic pipeline was developed for variant and indel detection. In one family with two affected siblings, and in a second family with a single affected individual, we detected maternally inherited deletions of 40 and 33 bp, respectively, within the deletion previously reported in rare families with PHP1b. All three affected individuals presented with atypically severe PHP1b; interestingly, the unaffected mother in one family had the detected deletion on her maternally inherited allele. Targeted NGS can reveal sequence changes undetectable by current diagnostic methods. Identification of genetic mutations underlying epigenetic changes can facilitate accurate diagnosis and counselling, and potentially highlight genetic elements critical for normal imprint settin
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Rejection thresholds (RjT) of sweet likers and dislikers
Sweetness is generally a desirable taste, however consumers can be grouped into sweet likers and dislikers according to optimally preferred sucrose concentrations. Understanding the levels of sweetness in products that are acceptable and unacceptable to both consumer groups is important to product development and for influencing dietary habits. The concentrations at which sucrose decreases liking (the rejection threshold; RjT) in liquid and semi-solid matrices were investigated in this study. Thirty six consumers rated their liking of 5 sucrose aqueous solutions; this identified 36% sweet likers (SL) whose liking ratings increased with increasing sucrose and 64% sweet dislikers (SD) whose liking ratings decreased above 6% (w/v) sucrose. We hypothesized that SL and SD would have different RjT for sucrose in products. This was tested by preparing 8 levels of sucrose in orange juice and orange jelly and presenting each against the lowest level in forced choice preference tests. In orange juice, as sucrose increased from 33g/L to 75g/L the proportion of people preferring the sweeter sample increased in both groups. However, at higher sucrose levels, the proportion of consumers preferring the sweet sample decreased. For SD, a RjT was reached at 380 g/L, whereas a significant RjT for SL was not reached. RjT in jelly were not reached as the sweetness in orange jelly was significantly lower than for orange juice (p<0.001). Despite statistically significant differences in rated sweetness between SL and SD (p=0.019), the extent of difference between the two groups was minor. The results implied that sweet liker status was not substantially related to differences in sweetness perception. Self-reported dietary intake of carbohydrate, sugars and sucrose were not significantly affected by sweet liker status. However the failure to find an effect may be due to the small sample size and future studies within a larger, more representative population sample are justifiable from the results of this study
Tacrolimus Toxicity Associated with Concomitant Metoclopramide Therapy
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90417/1/phco.24.5.532.33357.pd
Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a
Cyclooxygenase-2 (COX-2) is expressed early in colon carcinogenesis and is known to play a crucial role in the progress of the disease. Here we show that the regulation of the expression of this enzyme in a colon cancer cell line, and in patients, is associated with overexpression of the Wnt pathway-associated proteins, Pontin52/TIP49a and LEF-1. Recently shown to be essential for transformation via the c-Myc pathway, Pontin52/TIP49a promotes COX-2 expression in tissue culture and is overexpressed in colon cancer tissue, co-localizing with COX-2 expression in transformed tissue, relative to paired normal tissue
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