13 research outputs found
Age standardized prevalence of ATP III, IDF and Harmonization metabolic syndrome.
<p>Adjustment has been performed for sex and urban-rural location.</p
Crude and age standardized prevalence of metabolic syndrome using ATP III, IDF and Harmonization definitions.
<p>Crude and age standardized prevalence of metabolic syndrome using ATP III, IDF and Harmonization definitions.</p
Crude prevalence, unadjusted and adjusted odds ratios for definite coronary artery disease among participants with metabolic syndrome.
<p>Crude prevalence, unadjusted and adjusted odds ratios for definite coronary artery disease among participants with metabolic syndrome.</p
Diagnostic criteria for metabolic syndrome for ATP III, IDF and Harmonization definitions.
<p>Diagnostic criteria for metabolic syndrome for ATP III, IDF and Harmonization definitions.</p
Risk factors associated with ATP III metabolic syndrome in a univariate logistic regression model.
<p>Risk factors associated with ATP III metabolic syndrome in a univariate logistic regression model.</p
Participant age and education status stratified by sex and geographic location.
<p>Participant age and education status stratified by sex and geographic location.</p
Risk factors associated with ATP III metabolic syndrome in a multivariate logistic regression model.
<p>Risk factors associated with ATP III metabolic syndrome in a multivariate logistic regression model.</p
Age standardized prevalence of individual criteria for metabolic syndrome, related diagnoses and other potential risk factors among study participants.
<p>Age standardized prevalence of individual criteria for metabolic syndrome, related diagnoses and other potential risk factors among study participants.</p
Comprehensive Maturity Onset Diabetes of the Young (MODY) Gene Screening in Pregnant Women with Diabetes in India
<div><p>Pregnant women with diabetes may have underlying beta cell dysfunction due to mutations/rare variants in genes associated with Maturity Onset Diabetes of the Young (MODY). MODY gene screening would reveal those women genetically predisposed and previously unrecognized with a monogenic form of diabetes for further clinical management, family screening and genetic counselling. However, there are minimal data available on MODY gene variants in pregnant women with diabetes from India. In this study, utilizing the Next generation sequencing (NGS) based protocol fifty subjects were screened for variants in a panel of thirteen MODY genes. Of these subjects 18% (9/50) were positive for definite or likely pathogenic or uncertain MODY variants. The majority of these variants was identified in subjects with autosomal dominant family history, of whom five were in women with pre-GDM and four with overt-GDM. The identified variants included one patient with <i>HNF1A</i> Ser3Cys, two <i>PDX1</i> Glu224Lys, His94Gln, two <i>NEUROD1</i> Glu59Gln, Phe318Ser, one <i>INS</i> Gly44Arg, one <i>GCK</i>, <i>one ABCC8</i> Arg620Cys and one <i>BLK</i> Val418Met variants. In addition, three of the seven offspring screened were positive for the identified variant. These identified variants were further confirmed by Sanger sequencing. In conclusion, these findings in pregnant women with diabetes, imply that a proportion of GDM patients with autosomal dominant family history may have MODY. Further NGS based comprehensive studies with larger samples are required to confirm these finding</p></div
Detailed diagrammatic algorithm of the study with flow chart of NGS screening of the subject.
<p>Detailed diagrammatic algorithm of the study with flow chart of NGS screening of the subject.</p