75 research outputs found
Dislocation core field. I. Modeling in anisotropic linear elasticity theory
Aside from the Volterra field, dislocations create a core field, which can be
modeled in linear anisotropic elasticity theory with force and dislocation
dipoles. We derive an expression of the elastic energy of a dislocation taking
full account of its core field and show that no cross term exists between the
Volterra and the core fields. We also obtain the contribution of the core field
to the dislocation interaction energy with an external stress, thus showing
that dislocation can interact with a pressure. The additional force that
derives from this core field contribution is proportional to the gradient of
the applied stress. Such a supplementary force on dislocations may be important
in high stress gradient regions, such as close to a crack tip or in a
dislocation pile-up
Mycoplasma hyopneumoniae evades phagocytic uptake by porcine alveolar macrophages in vitro
Mycoplasma hyopneumoniae, the agent of porcine enzootic pneumonia (EP), is able to persist in the lung tissue and evade destruction by the host for several weeks. To understand the mechanism of pathogen survival, phagocytic uptake of M. hyopneumoniae by primary porcine alveolar macrophages was investigated. Intracellular location and survival of the pathogen were explored using gentamicin survival assays, flow cytometry and confocal microscopy of M. hyopneumoniae 232 labelled with green fluorescent protein (GFP). Following 1 h and 16 h of co-incubation, few viable M. hyopneumoniae were recovered from inside macrophages. Flow cytometric analysis of macrophages incubated with M. hyopneumoniae expressing GFP indicated that the mycoplasmas became associated with macrophages, but were shown to be extracellular when actin-dependent phagocytosis was blocked with cytochalasin D. Confocal microscopy detected GFP-labelled M. hyopneumoniae inside macrophages and the numbers increased modestly with time of incubation. Neither the addition of porcine serum complement or convalescent serum from EP-recovered pigs was able to enhance engulfment of M. hyopneumoniae. This investigation suggests that M. hyopneumoniae evades significant uptake by porcine alveolar macrophages and this may be a mechanism of immune escape by M. hyopneumoniae in the porcine respiratory tract
Muon Physics: A Pillar of the Standard Model
Since its discovery in the 1930s, the muon has played an important role in
our quest to understand the sub-atomic theory of matter. The muon was the first
second-generation standard-model particle to be discovered, and its decay has
provided information on the (Vector -Axial Vector) structure of the weak
interaction, the strength of the weak interaction, G_F, and the conservation of
lepton number (flavor) in muon decay. The muon's anomalous magnetic moment has
played an important role in restricting theories of physics beyond the standard
standard model, where at present there is a 3.4 standard-deviation difference
between the experiment and standard-model theory. Its capture on the atomic
nucleus has provided valuable information on the modification of the weak
current by the strong interaction which is complementary to that obtained from
nuclear beta decay.Comment: 8 pages, 9 figures. Invited paper for the Journal of Physical Society
in Japan (JPSJ), Special Topics Issue "Frontiers of Elementary Particle
Physics, The Standard Model and beyond
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